Therapeutic Targets for Influenza - Perspectives in Drug Development
Since new and dangerous influenza virus strains, such as H5N1 "avian flu" and more recently the swine-origin H1N1 "swine flu", are constantly evolving, the need for effective anti-influenza drugs is pressing. It is becoming clear that the emergence of drug-resistant viruses will...
Published in: | Collection of Czechoslovak Chemical Communications |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2010
|
Subjects: | |
Online Access: | https://doi.org/10.1135/cccc2009087 http://hdl.handle.net/11104/0192850 |
id |
ftczacademyscien:oai:asep.lib.cas.cz:CavUnEpca/0353675 |
---|---|
record_format |
openpolar |
spelling |
ftczacademyscien:oai:asep.lib.cas.cz:CavUnEpca/0353675 2024-02-04T09:59:01+01:00 Therapeutic Targets for Influenza - Perspectives in Drug Development Majerová, T. (Taťána) Hoffman, H. Majer, F. 2010 https://doi.org/10.1135/cccc2009087 http://hdl.handle.net/11104/0192850 eng eng doi:10.1135/cccc2009087 urn:pissn: 0010-0765 http://hdl.handle.net/11104/0192850 influenza drug research protein structure oligonucleotides info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2010 ftczacademyscien https://doi.org/10.1135/cccc2009087 2024-01-09T17:16:04Z Since new and dangerous influenza virus strains, such as H5N1 "avian flu" and more recently the swine-origin H1N1 "swine flu", are constantly evolving, the need for effective anti-influenza drugs is pressing. It is becoming clear that the emergence of drug-resistant viruses will be a major potential problem in future efforts to control influenza virus infection. Moreover, development of vaccines against new influenza strains takes several months, and their production capacity is limited. Thus, new classes of anti-influenza drugs are highly sought after. This review focuses mainly on novel strategies, including targeting viral entry into host cells, inhibition of viral transcription and genome replication, and targeting of the NS1 influenza protein. Another approach involves viral RNA silencing by siRNAs or by antisense oligonucleotides. Article in Journal/Newspaper Avian flu The Czech Academy of Sciences: Publication Activity (ASEP) Collection of Czechoslovak Chemical Communications 75 1 81 103 |
institution |
Open Polar |
collection |
The Czech Academy of Sciences: Publication Activity (ASEP) |
op_collection_id |
ftczacademyscien |
language |
English |
topic |
influenza drug research protein structure oligonucleotides |
spellingShingle |
influenza drug research protein structure oligonucleotides Majerová, T. (Taťána) Hoffman, H. Majer, F. Therapeutic Targets for Influenza - Perspectives in Drug Development |
topic_facet |
influenza drug research protein structure oligonucleotides |
description |
Since new and dangerous influenza virus strains, such as H5N1 "avian flu" and more recently the swine-origin H1N1 "swine flu", are constantly evolving, the need for effective anti-influenza drugs is pressing. It is becoming clear that the emergence of drug-resistant viruses will be a major potential problem in future efforts to control influenza virus infection. Moreover, development of vaccines against new influenza strains takes several months, and their production capacity is limited. Thus, new classes of anti-influenza drugs are highly sought after. This review focuses mainly on novel strategies, including targeting viral entry into host cells, inhibition of viral transcription and genome replication, and targeting of the NS1 influenza protein. Another approach involves viral RNA silencing by siRNAs or by antisense oligonucleotides. |
format |
Article in Journal/Newspaper |
author |
Majerová, T. (Taťána) Hoffman, H. Majer, F. |
author_facet |
Majerová, T. (Taťána) Hoffman, H. Majer, F. |
author_sort |
Majerová, T. (Taťána) |
title |
Therapeutic Targets for Influenza - Perspectives in Drug Development |
title_short |
Therapeutic Targets for Influenza - Perspectives in Drug Development |
title_full |
Therapeutic Targets for Influenza - Perspectives in Drug Development |
title_fullStr |
Therapeutic Targets for Influenza - Perspectives in Drug Development |
title_full_unstemmed |
Therapeutic Targets for Influenza - Perspectives in Drug Development |
title_sort |
therapeutic targets for influenza - perspectives in drug development |
publishDate |
2010 |
url |
https://doi.org/10.1135/cccc2009087 http://hdl.handle.net/11104/0192850 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
doi:10.1135/cccc2009087 urn:pissn: 0010-0765 http://hdl.handle.net/11104/0192850 |
op_doi |
https://doi.org/10.1135/cccc2009087 |
container_title |
Collection of Czechoslovak Chemical Communications |
container_volume |
75 |
container_issue |
1 |
container_start_page |
81 |
op_container_end_page |
103 |
_version_ |
1789963656107130880 |