Enzymatic synthesis of perillyl alcohol derivatives and investigation of their antiproliferative activity

• Published in: Biocatalysis and Biotransformation
• Main Authors: Xanthakis, Epameinondas, Magkouta, Sophia, Loutrari, Heleni, Stamatis, Haralambos, Roussos, Charis, Kolisis, Fragiskos N.
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2009
• Subjects: Perillyl alcohol; Enzymatic glucosylation/acylation; Glucosidas; Lipase B; Antitumor growth activity; Other Engineering and Technologies; Engineering and Technology; Almond; Antarc*; Antarctica
• Online Access: https://hdl.handle.net/10488/27522; https://doi.org/10.1080/10242420902811089; https://api.elsevier.com/content/abstract/scopus_id/68049106060

The monoterpene perillyl alcohol (POH), an intermediate in the plant terpenoid biosynthetic pathway, has well-established tumor chemopreventive and chemotherapeutic potential. We have previously shown that the primary hydroxyl group of POH is essential for its antitumor and anti-angiogenic activitie...