АНАЛИЗ АССОЦИАЦИИ ЭПСИЛОН ПОЛИМОРФИЗМА ГЕНА АПОЛИПОПРОТЕИНА Е С РИСКОМ РАЗВИТИЯ РАССЕЯННОГО СКЛЕРОЗА

• Main Authors: Николаева, И., Максимова, Н., Николаева, Т., Пузырев, В.
• Format: Text
• Language: unknown
• Published: Федеральное государственное бюджетное учреждение «Научно-исследовательский институт кардиологии» Сибирского отделения Российской академии медицинских наук 2007
• Subjects: Multiple sclerosis; development risk; ApoE gene polymorphism; рассеянный склероз; риск развития; полиморфизм гена апоЕ; Yakutia; Yakuts
• Online Access: http://cyberleninka.ru/article/n/analiz-assotsiatsii-epsilon-polimorfizma-gena-apolipoproteina-e-s-riskom-razvitiya-rasseyannogo-skleroza; http://cyberleninka.ru/article_covers/4740731.png

We compared the frequencies of АРОЕ genotypes and alleles in indigenous population of Yakutia (Russians, Yakuts) and patients with Multiple Sclerosis. In healthy Yakuts group, as compared with healthy Russians group, no statistically significant associations. In group of patients with Multiple Sclerosis were higher АРОЕ ε4 heterozygote frequency. We found an earlier age of onset in the group of Russian women for АРОЕ ε4 allele positive. Progression index is higher in АРОЕ ε4 allele negative group. We compared the frequencies of АРОЕ genotypes and alleles in indigenous population of Yakutia (Russians, Yakuts) and patients with Multiple Sclerosis. In healthy Yakuts group, as compared with healthy Russians group, no statistically significant associations. In group of patients with Multiple Sclerosis were higher АРОЕ ε4 heterozygote frequency. We found an earlier age of onset in the group of Russian women for АРОЕ ε4 allele positive. Progression index is higher in АРОЕ ε4 allele negative group.