Regio-selective acylation of biologically important iridoid glycosides by Candida antarctica lipase
Lipase catalyzed regio-selective acylation of five iridoid glycosides viz., picroside I&II, catalpol, agnuside and negundoside in the presence of various acyl donors such as vinyl acetate and p-nitrophenyl alkanoates was studied. The regio-selectivity of enzymatic acylation and yieldswere found...
Published in: | Journal of Molecular Catalysis B: Enzymatic |
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Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
2009
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Subjects: | |
Online Access: | http://iiim.csircentral.net/331/ http://iiim.csircentral.net/331/1/10.1016j.molcatb.2008.04.005.pdf https://doi.org/10.1016/j.molcatb.2008.04.005 |
Summary: | Lipase catalyzed regio-selective acylation of five iridoid glycosides viz., picroside I&II, catalpol, agnuside and negundoside in the presence of various acyl donors such as vinyl acetate and p-nitrophenyl alkanoates was studied. The regio-selectivity of enzymatic acylation and yieldswere found to vary amongst different substrates. Monoacylated products were isolated with all the substrates under scrutiny indicating high regio-selective nature of such transformations. A series of acyl esters of picroside-I, picroside-II, catalpol, agnuside and negundoside have been synthesized by this enzymatic trans-esterification methodology. |
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