Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost
12 páginas, 11 figuras, 3 tablas Dietary long chain polyunsaturated fatty acids (FA) have been recognized of crucial importance in early development of vertebrates, contributing to the impressive morphological and physiological changes both as building blocks and to energy production. The importance...
Published in: | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology |
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ftcsic:oai:digital.csic.es:10261/72133 2024-02-11T10:08:27+01:00 Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost Cunha, Isabel Galante-Oliveira, S. Rocha, E. Planas, Miguel Urbatzka, R. Castro, L. Filipe C. 2013 http://hdl.handle.net/10261/72133 https://doi.org/10.1016/j.cbpb.2013.01.003 en eng Elsevier http://dx.doi.org/10.1016/j.cbpb.2013.01.003 Comparative Biochemistry and Physiology - B - Biochemistry and Molecular Biology 164(4): 247-258 (2013) 1096-4959 http://hdl.handle.net/10261/72133 doi:10.1016/j.cbpb.2013.01.003 1879-1107 open Fish embryos Gene transcription Lipid metabolism Peroxisome proliferator activated receptors Scophthalmus maximus artículo http://purl.org/coar/resource_type/c_6501 2013 ftcsic https://doi.org/10.1016/j.cbpb.2013.01.003 2024-01-16T09:47:34Z 12 páginas, 11 figuras, 3 tablas Dietary long chain polyunsaturated fatty acids (FA) have been recognized of crucial importance in early development of vertebrates, contributing to the impressive morphological and physiological changes both as building blocks and to energy production. The importance of lipids along development depends on ontogenetic, phylogenetic and environmental parameters. The expression patterns of FA metabolism genes have not been characterized in developing fish embryos nor compared to lipid class profiles. Full lipid metabolism only occurred after hatching, as revealed by alterations in lipid profiles and FA gene expression. Nonetheless, transcriptional changes of some FA genes were already present in embryos at notochord formation. Many genes displayed an expression profile opposed to the decrease of lipids along the development, while others responded solely to starvation. Transcription of most genes involved in FA metabolism had a strong correlation to PPARs' mRNA levels (α1, α2, β, γ). The comparison of mRNA expression of the genes with the lipid profiles produced new insights into the FA metabolism and regulation during the development of turbot larvae, providing the basis for future studies including comparative approaches with other vertebrate species. This work was developed under the research project PTDC/MAR/68885/2006, funded by the Portuguese Foundation for Science and Technology (FCT) and by the “Programa Operacional Ciência e Inovação 2010” (POCI 2010), co-financed by the FEDER European Community fund. Peer reviewed Article in Journal/Newspaper Scophthalmus maximus Turbot Digital.CSIC (Spanish National Research Council) Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 164 4 247 258 |
institution |
Open Polar |
collection |
Digital.CSIC (Spanish National Research Council) |
op_collection_id |
ftcsic |
language |
English |
topic |
Fish embryos Gene transcription Lipid metabolism Peroxisome proliferator activated receptors Scophthalmus maximus |
spellingShingle |
Fish embryos Gene transcription Lipid metabolism Peroxisome proliferator activated receptors Scophthalmus maximus Cunha, Isabel Galante-Oliveira, S. Rocha, E. Planas, Miguel Urbatzka, R. Castro, L. Filipe C. Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost |
topic_facet |
Fish embryos Gene transcription Lipid metabolism Peroxisome proliferator activated receptors Scophthalmus maximus |
description |
12 páginas, 11 figuras, 3 tablas Dietary long chain polyunsaturated fatty acids (FA) have been recognized of crucial importance in early development of vertebrates, contributing to the impressive morphological and physiological changes both as building blocks and to energy production. The importance of lipids along development depends on ontogenetic, phylogenetic and environmental parameters. The expression patterns of FA metabolism genes have not been characterized in developing fish embryos nor compared to lipid class profiles. Full lipid metabolism only occurred after hatching, as revealed by alterations in lipid profiles and FA gene expression. Nonetheless, transcriptional changes of some FA genes were already present in embryos at notochord formation. Many genes displayed an expression profile opposed to the decrease of lipids along the development, while others responded solely to starvation. Transcription of most genes involved in FA metabolism had a strong correlation to PPARs' mRNA levels (α1, α2, β, γ). The comparison of mRNA expression of the genes with the lipid profiles produced new insights into the FA metabolism and regulation during the development of turbot larvae, providing the basis for future studies including comparative approaches with other vertebrate species. This work was developed under the research project PTDC/MAR/68885/2006, funded by the Portuguese Foundation for Science and Technology (FCT) and by the “Programa Operacional Ciência e Inovação 2010” (POCI 2010), co-financed by the FEDER European Community fund. Peer reviewed |
format |
Article in Journal/Newspaper |
author |
Cunha, Isabel Galante-Oliveira, S. Rocha, E. Planas, Miguel Urbatzka, R. Castro, L. Filipe C. |
author_facet |
Cunha, Isabel Galante-Oliveira, S. Rocha, E. Planas, Miguel Urbatzka, R. Castro, L. Filipe C. |
author_sort |
Cunha, Isabel |
title |
Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost |
title_short |
Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost |
title_full |
Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost |
title_fullStr |
Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost |
title_full_unstemmed |
Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost |
title_sort |
dynamics of ppars, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost |
publisher |
Elsevier |
publishDate |
2013 |
url |
http://hdl.handle.net/10261/72133 https://doi.org/10.1016/j.cbpb.2013.01.003 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_relation |
http://dx.doi.org/10.1016/j.cbpb.2013.01.003 Comparative Biochemistry and Physiology - B - Biochemistry and Molecular Biology 164(4): 247-258 (2013) 1096-4959 http://hdl.handle.net/10261/72133 doi:10.1016/j.cbpb.2013.01.003 1879-1107 |
op_rights |
open |
op_doi |
https://doi.org/10.1016/j.cbpb.2013.01.003 |
container_title |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology |
container_volume |
164 |
container_issue |
4 |
container_start_page |
247 |
op_container_end_page |
258 |
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1790607793871388672 |