Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta
et al. Neurotrophins (NTs) and their signal transducing Trk receptors play a critical role in the development and maintenance of specific neuronal populations in the nervous system of higher vertebrates. They are responsible for the innervation of the inner ear cochlear and vestibular sensory epithe...
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ftcsic:oai:digital.csic.es:10261/71885 2024-02-11T10:08:19+01:00 Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta Catania, S. Cabo, R. Represa, J. 2007 http://hdl.handle.net/10261/71885 https://doi.org/10.1111/j.1469-7580.2006.00673.x en eng Wiley-Blackwell doi:10.1111/j.1469-7580.2006.00673.x issn: 0021-8782 e-issn: 1469-7580 Journal of Anatomy 210(1): 78-88 (2007) http://hdl.handle.net/10261/71885 17229285 none artículo http://purl.org/coar/resource_type/c_6501 2007 ftcsic https://doi.org/10.1111/j.1469-7580.2006.00673.x 2024-01-16T09:47:29Z et al. Neurotrophins (NTs) and their signal transducing Trk receptors play a critical role in the development and maintenance of specific neuronal populations in the nervous system of higher vertebrates. They are responsible for the innervation of the inner ear cochlear and vestibular sensory epithelia. Neurotrophins and Trks are also present in teleosts but their distribution in the inner ear is unknown. Thus, in the present study, we used Western-blot analysis and immunohistochemistry to investigate the expression and cell localization of both NTs and Trk receptors in the inner ear of alevins of Salmo salar and Salmo trutta. Western-blot analysis revealed the occurrence of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not nerve growth factor (NGF), as well as all three Trk receptors, i.e. TrkA, TrkB and TrkC, the estimated molecular weights of which were similar to those expected for mammals. Specific immunoreactivity for neurotrophins was detected mainly in the sensory epithelia. In particular, BDNF immunoreactivity was found in the maculae of the utricle and saccule, whereas NT-3 immunoreactivity was present in the sensory epithelium of the cristae ampullaris. As a rule the sensory epithelia of the inner ear lacked immunoreactivity for Trks, thus excluding possible mechanisms of autocrinia and/or paracrinia. By contrast, overlapping subpopulations of neurons in the statoacoustic ganglion expressed TrkA (about 15%), TrkB (about 65%) and TrkC (about 45%). The present results demonstrate that, as in mammals and birds, the inner ear of teleosts expresses the components of the neurotrophin-Trk system, but their roles remain to be elucidated. © 2006 The Authors Journal compilation © 2006 Anatomical Society of Great Britain and Ireland. Peer Reviewed Article in Journal/Newspaper Salmo salar Digital.CSIC (Spanish National Research Council) Journal of Anatomy 210 1 78 88 |
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Digital.CSIC (Spanish National Research Council) |
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ftcsic |
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English |
description |
et al. Neurotrophins (NTs) and their signal transducing Trk receptors play a critical role in the development and maintenance of specific neuronal populations in the nervous system of higher vertebrates. They are responsible for the innervation of the inner ear cochlear and vestibular sensory epithelia. Neurotrophins and Trks are also present in teleosts but their distribution in the inner ear is unknown. Thus, in the present study, we used Western-blot analysis and immunohistochemistry to investigate the expression and cell localization of both NTs and Trk receptors in the inner ear of alevins of Salmo salar and Salmo trutta. Western-blot analysis revealed the occurrence of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not nerve growth factor (NGF), as well as all three Trk receptors, i.e. TrkA, TrkB and TrkC, the estimated molecular weights of which were similar to those expected for mammals. Specific immunoreactivity for neurotrophins was detected mainly in the sensory epithelia. In particular, BDNF immunoreactivity was found in the maculae of the utricle and saccule, whereas NT-3 immunoreactivity was present in the sensory epithelium of the cristae ampullaris. As a rule the sensory epithelia of the inner ear lacked immunoreactivity for Trks, thus excluding possible mechanisms of autocrinia and/or paracrinia. By contrast, overlapping subpopulations of neurons in the statoacoustic ganglion expressed TrkA (about 15%), TrkB (about 65%) and TrkC (about 45%). The present results demonstrate that, as in mammals and birds, the inner ear of teleosts expresses the components of the neurotrophin-Trk system, but their roles remain to be elucidated. © 2006 The Authors Journal compilation © 2006 Anatomical Society of Great Britain and Ireland. Peer Reviewed |
format |
Article in Journal/Newspaper |
author |
Catania, S. Cabo, R. Represa, J. |
spellingShingle |
Catania, S. Cabo, R. Represa, J. Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta |
author_facet |
Catania, S. Cabo, R. Represa, J. |
author_sort |
Catania, S. |
title |
Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta |
title_short |
Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta |
title_full |
Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta |
title_fullStr |
Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta |
title_full_unstemmed |
Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar and Salmo trutta |
title_sort |
neurotrophin and trk neurotrophin receptors in the inner ear of salmo salar and salmo trutta |
publisher |
Wiley-Blackwell |
publishDate |
2007 |
url |
http://hdl.handle.net/10261/71885 https://doi.org/10.1111/j.1469-7580.2006.00673.x |
genre |
Salmo salar |
genre_facet |
Salmo salar |
op_relation |
doi:10.1111/j.1469-7580.2006.00673.x issn: 0021-8782 e-issn: 1469-7580 Journal of Anatomy 210(1): 78-88 (2007) http://hdl.handle.net/10261/71885 17229285 |
op_rights |
none |
op_doi |
https://doi.org/10.1111/j.1469-7580.2006.00673.x |
container_title |
Journal of Anatomy |
container_volume |
210 |
container_issue |
1 |
container_start_page |
78 |
op_container_end_page |
88 |
_version_ |
1790607406210744320 |