Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3
This paper compares the pleiotropic effects of statins and omega-3 fatty acids (n-3 PUFA) in treating and preventing cardiovascular disease (CVD) and deals with the possible interactions of those compounds. Statins represent one of the most important discoveries to have been made in the field of car...
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ftcsic:oai:digital.csic.es:10261/63028 2024-02-11T10:03:34+01:00 Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 Villalobos, M. E. Sánchez-Muniz, F. J. Acín, M. T. Vaquero, M. Pilar Higueras, F. J. Bastida, Sara 2010 http://hdl.handle.net/10261/63028 https://doi.org/10.3305/nh.2010.25.6.4819 es spa Aula Médica Ediciones doi:10.3305/nh.2010.25.6.4819 issn: 0212-1611 e-issn: 1699-5198 Nutricion Hospitalaria 25: 889- 909 (2010) http://hdl.handle.net/10261/63028 open artículo http://purl.org/coar/resource_type/c_6501 2010 ftcsic https://doi.org/10.3305/nh.2010.25.6.4819 2024-01-16T09:43:44Z This paper compares the pleiotropic effects of statins and omega-3 fatty acids (n-3 PUFA) in treating and preventing cardiovascular disease (CVD) and deals with the possible interactions of those compounds. Statins represent one of the most important discoveries to have been made in the field of cardiovascular medicine in recent decades. Their beneficial cardiovascular effects, which have reduced the number of fatal events in patients with atherosclerosis, encompass more than their ability to lower cholesterol levels. The pleiotropic effects of statins involve their anti-inflammatory and antiplatelet properties and their ability to normalize endothelial function. In addition, these drugs may display antiarrhythmic activity, improve insulin sensitivity and counteract hypertension and obesity. The low rate of coronary disease documented in Eskimos corroborates the cardioprotective effects of the n-3 PUFA eicosapentaenoic (EPA) and docosahexaenoic acids beyond their hypolipemic effects. The reduction of CVD-related deaths attributable to the action of α-linolenic fatty acid appears to be related to its strong antiarrhythmic properties. In addition, as a precursor of EPA and this last fatty acid of thromboxane A3, prostacyclin I3, serie-3 prostaglandines and serie 5- leukotrines and inhibitor/modulator of thromboxane A2, prostacyclin I2, serie-2 prostaglandines and serie 4- leukotrienes formation, the α-linolenic acid may reduce inflammation and thrombogenesis. As results of some studies suggest that the combined use of statins and n-3 PUFA improves cardiovascular protection and reduces the CVD-related mortality rate; the paper also reviews the possible synergism between both groups of compounds on CVD treatment and concludes that clear benefits may be obtained. Peer Reviewed Article in Journal/Newspaper eskimo* Digital.CSIC (Spanish National Research Council) |
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Open Polar |
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Digital.CSIC (Spanish National Research Council) |
op_collection_id |
ftcsic |
language |
Spanish |
description |
This paper compares the pleiotropic effects of statins and omega-3 fatty acids (n-3 PUFA) in treating and preventing cardiovascular disease (CVD) and deals with the possible interactions of those compounds. Statins represent one of the most important discoveries to have been made in the field of cardiovascular medicine in recent decades. Their beneficial cardiovascular effects, which have reduced the number of fatal events in patients with atherosclerosis, encompass more than their ability to lower cholesterol levels. The pleiotropic effects of statins involve their anti-inflammatory and antiplatelet properties and their ability to normalize endothelial function. In addition, these drugs may display antiarrhythmic activity, improve insulin sensitivity and counteract hypertension and obesity. The low rate of coronary disease documented in Eskimos corroborates the cardioprotective effects of the n-3 PUFA eicosapentaenoic (EPA) and docosahexaenoic acids beyond their hypolipemic effects. The reduction of CVD-related deaths attributable to the action of α-linolenic fatty acid appears to be related to its strong antiarrhythmic properties. In addition, as a precursor of EPA and this last fatty acid of thromboxane A3, prostacyclin I3, serie-3 prostaglandines and serie 5- leukotrines and inhibitor/modulator of thromboxane A2, prostacyclin I2, serie-2 prostaglandines and serie 4- leukotrienes formation, the α-linolenic acid may reduce inflammation and thrombogenesis. As results of some studies suggest that the combined use of statins and n-3 PUFA improves cardiovascular protection and reduces the CVD-related mortality rate; the paper also reviews the possible synergism between both groups of compounds on CVD treatment and concludes that clear benefits may be obtained. Peer Reviewed |
format |
Article in Journal/Newspaper |
author |
Villalobos, M. E. Sánchez-Muniz, F. J. Acín, M. T. Vaquero, M. Pilar Higueras, F. J. Bastida, Sara |
spellingShingle |
Villalobos, M. E. Sánchez-Muniz, F. J. Acín, M. T. Vaquero, M. Pilar Higueras, F. J. Bastida, Sara Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 |
author_facet |
Villalobos, M. E. Sánchez-Muniz, F. J. Acín, M. T. Vaquero, M. Pilar Higueras, F. J. Bastida, Sara |
author_sort |
Villalobos, M. E. |
title |
Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 |
title_short |
Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 |
title_full |
Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 |
title_fullStr |
Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 |
title_full_unstemmed |
Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | Similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 |
title_sort |
similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids | similitudes, diferencias y agonismos en los efectos pleiotrópicos de las estatinas y los ácidos grasos omega-3 |
publisher |
Aula Médica Ediciones |
publishDate |
2010 |
url |
http://hdl.handle.net/10261/63028 https://doi.org/10.3305/nh.2010.25.6.4819 |
genre |
eskimo* |
genre_facet |
eskimo* |
op_relation |
doi:10.3305/nh.2010.25.6.4819 issn: 0212-1611 e-issn: 1699-5198 Nutricion Hospitalaria 25: 889- 909 (2010) http://hdl.handle.net/10261/63028 |
op_rights |
open |
op_doi |
https://doi.org/10.3305/nh.2010.25.6.4819 |
_version_ |
1790599859885047808 |