Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds
7 figuras, 2 tablas Nodaviruses are the etiological agents of one of the most serious viral diseases affecting marine fish aquaculture. Nodavirus infection produces an abnormal swimming behaviour and causes encephalopathy and retinopathy associated to important mortalities. The expression of TNF-α,...
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ftcsic:oai:digital.csic.es:10261/48019 2024-02-11T10:08:26+01:00 Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds Montes, Ariana Figueras Huerta, Antonio Novoa, Beatriz 2010 http://hdl.handle.net/10261/48019 https://doi.org/10.1016/j.fsi.2009.11.002 en eng Elsevier http://dx.doi.org/10.1016/j.fsi.2009.11.002 Fish and Shellfish Immunology 28(2): 281-288 (2010) 1050-4648 http://hdl.handle.net/10261/48019 doi:10.1016/j.fsi.2009.11.002 1095-9947 open Turbot Scophthalmus maximus Nodavirus Inflammation Nitric oxide artículo http://purl.org/coar/resource_type/c_6501 2010 ftcsic https://doi.org/10.1016/j.fsi.2009.11.002 2024-01-16T09:37:04Z 7 figuras, 2 tablas Nodaviruses are the etiological agents of one of the most serious viral diseases affecting marine fish aquaculture. Nodavirus infection produces an abnormal swimming behaviour and causes encephalopathy and retinopathy associated to important mortalities. The expression of TNF-α, IRF-1 and Mx was increased in turbot after nodavirus infection. A significant increase in the production of nitrogen radicals was also observed in experimentally infected turbot. Several anti-inflammatory compounds (the antioxidant N-acetylcysteine, cortisone, dexamethasone, prednisolone and aminoguanidine) were assayed to determine the role of inflammation on nodavirus infection. Cortisone and aminoguanidine were able to accelerate the mortality onset associated to nodavirus infection, modulating the gene expression of TNF-α and, in addition, modifying the arrival time of nodavirus to the brain. These results suggest the importance of early inflammatory processes to overcome the infection. This work was supported by the project CSD2007-00002 “Aquagenomics” funded by the program Consolider-Ingenio 2010 from the Spanish Ministerio de Ciencia e Innovación, project PGIDITOGRMA23501PR from Xunta de Galicia (and the Canadian-Spanish program NRC-MEC. Peer reviewed Article in Journal/Newspaper Scophthalmus maximus Turbot Digital.CSIC (Spanish National Research Council) Fish & Shellfish Immunology 28 2 281 288 |
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Open Polar |
collection |
Digital.CSIC (Spanish National Research Council) |
op_collection_id |
ftcsic |
language |
English |
topic |
Turbot Scophthalmus maximus Nodavirus Inflammation Nitric oxide |
spellingShingle |
Turbot Scophthalmus maximus Nodavirus Inflammation Nitric oxide Montes, Ariana Figueras Huerta, Antonio Novoa, Beatriz Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds |
topic_facet |
Turbot Scophthalmus maximus Nodavirus Inflammation Nitric oxide |
description |
7 figuras, 2 tablas Nodaviruses are the etiological agents of one of the most serious viral diseases affecting marine fish aquaculture. Nodavirus infection produces an abnormal swimming behaviour and causes encephalopathy and retinopathy associated to important mortalities. The expression of TNF-α, IRF-1 and Mx was increased in turbot after nodavirus infection. A significant increase in the production of nitrogen radicals was also observed in experimentally infected turbot. Several anti-inflammatory compounds (the antioxidant N-acetylcysteine, cortisone, dexamethasone, prednisolone and aminoguanidine) were assayed to determine the role of inflammation on nodavirus infection. Cortisone and aminoguanidine were able to accelerate the mortality onset associated to nodavirus infection, modulating the gene expression of TNF-α and, in addition, modifying the arrival time of nodavirus to the brain. These results suggest the importance of early inflammatory processes to overcome the infection. This work was supported by the project CSD2007-00002 “Aquagenomics” funded by the program Consolider-Ingenio 2010 from the Spanish Ministerio de Ciencia e Innovación, project PGIDITOGRMA23501PR from Xunta de Galicia (and the Canadian-Spanish program NRC-MEC. Peer reviewed |
format |
Article in Journal/Newspaper |
author |
Montes, Ariana Figueras Huerta, Antonio Novoa, Beatriz |
author_facet |
Montes, Ariana Figueras Huerta, Antonio Novoa, Beatriz |
author_sort |
Montes, Ariana |
title |
Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds |
title_short |
Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds |
title_full |
Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds |
title_fullStr |
Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds |
title_full_unstemmed |
Nodavirus encephalopathy in turbot (Scophthalmus maximus): Inflammation, nitric oxide production and effect of anti-inflammatory compounds |
title_sort |
nodavirus encephalopathy in turbot (scophthalmus maximus): inflammation, nitric oxide production and effect of anti-inflammatory compounds |
publisher |
Elsevier |
publishDate |
2010 |
url |
http://hdl.handle.net/10261/48019 https://doi.org/10.1016/j.fsi.2009.11.002 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_relation |
http://dx.doi.org/10.1016/j.fsi.2009.11.002 Fish and Shellfish Immunology 28(2): 281-288 (2010) 1050-4648 http://hdl.handle.net/10261/48019 doi:10.1016/j.fsi.2009.11.002 1095-9947 |
op_rights |
open |
op_doi |
https://doi.org/10.1016/j.fsi.2009.11.002 |
container_title |
Fish & Shellfish Immunology |
container_volume |
28 |
container_issue |
2 |
container_start_page |
281 |
op_container_end_page |
288 |
_version_ |
1790607753112190976 |