The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter
13 pages, 7 figures, supplementary information https://doi.org/10.1038/s42003-019-0713-y.-- Data availability: The nucleotide sequences corresponding to the aqp14 cDNAs from gilthead seabream, zebrafish and Atlantic salmon were deposited in GenBank with accession numbers MK883753, MK883754 and MK883...
Published in: | Communications Biology |
---|---|
Main Authors: | , , , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Nature Publishing Group
2019
|
Subjects: | |
Online Access: | http://hdl.handle.net/10261/342669 https://doi.org/10.1038/s42003-019-0713-y |
id |
ftcsic:oai:digital.csic.es:10261/342669 |
---|---|
record_format |
openpolar |
spelling |
ftcsic:oai:digital.csic.es:10261/342669 2024-02-11T10:02:09+01:00 The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter Chauvigné, François Yilmaz, Ozlem Ferré, Alba Fjelldal, Per Gunnar Finn, Roderick N. Cerdà, Joan Ministerio de Economía y Competitividad (España) Norwegian Research Council 2019-12 http://hdl.handle.net/10261/342669 https://doi.org/10.1038/s42003-019-0713-y en eng Nature Publishing Group #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//RYC-2015-17103/ES/RYC-2015-17103/ info:eu-repo/grantAgreement/MINECO//BES-2014-068745/ES/BES-2014-068745/ info:eu-repo/grantAgreement/MINECO//AGL2016-76802-R Publisher's version https://doi.org/10.1038/s42003-019-0713-y No Communications Biology 2: 462 (2019) http://hdl.handle.net/10261/342669 doi:10.1038/s42003-019-0713-y 2399-3642 31840107 open artículo 2019 ftcsic https://doi.org/10.1038/s42003-019-0713-y 2024-01-24T00:42:55Z 13 pages, 7 figures, supplementary information https://doi.org/10.1038/s42003-019-0713-y.-- Data availability: The nucleotide sequences corresponding to the aqp14 cDNAs from gilthead seabream, zebrafish and Atlantic salmon were deposited in GenBank with accession numbers MK883753, MK883754 and MK883755, respectively. All data generated or analysed during this study are included in this published article (and its supplementary information files).-- Data availability: The nucleotide sequences corresponding to the aqp14 cDNAs from gilthead seabream, zebrafish and Atlantic salmon were deposited in GenBank with accession numbers MK883753, MK883754 and MK883755, respectively. All data generated or analysed during this study are included in this published article (and its supplementary information files) Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in all vertebrate lineages except hagfishes and eutherian mammals. In contrast to the water-selective classical aquaporins, which have four aromatic-arginine constriction residues, Aqp14 proteins present five non-aromatic constriction residues and facilitate the permeation of water, urea, ammonia, H2O2 and glycerol. Immunocytochemical assays suggest that Aqp14 channels play important osmoregulatory roles in piscine seawater adaptation. Our data indicate that Aqp14 intracellular trafficking is tightly regulated by the vasotocinergic/isotocinergic neuropeptide and receptor systems, whereby protein kinase C and A transduction pathways phosphorylate highly conserved C-terminal residues to control channel plasma membrane insertion. The neuropeptide regulation of Aqp14 channels thus predates the vasotocin/vasopressin regulation of AQP2-5-6 orthologs observed in tetrapods. These findings demonstrate that vertebrate Aqp14 channels represent an ancient subfamily of neuropeptide-regulated polytransporters This ... Article in Journal/Newspaper Atlantic salmon Digital.CSIC (Spanish National Research Council) Communications Biology 2 1 |
institution |
Open Polar |
collection |
Digital.CSIC (Spanish National Research Council) |
op_collection_id |
ftcsic |
language |
English |
description |
13 pages, 7 figures, supplementary information https://doi.org/10.1038/s42003-019-0713-y.-- Data availability: The nucleotide sequences corresponding to the aqp14 cDNAs from gilthead seabream, zebrafish and Atlantic salmon were deposited in GenBank with accession numbers MK883753, MK883754 and MK883755, respectively. All data generated or analysed during this study are included in this published article (and its supplementary information files).-- Data availability: The nucleotide sequences corresponding to the aqp14 cDNAs from gilthead seabream, zebrafish and Atlantic salmon were deposited in GenBank with accession numbers MK883753, MK883754 and MK883755, respectively. All data generated or analysed during this study are included in this published article (and its supplementary information files) Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in all vertebrate lineages except hagfishes and eutherian mammals. In contrast to the water-selective classical aquaporins, which have four aromatic-arginine constriction residues, Aqp14 proteins present five non-aromatic constriction residues and facilitate the permeation of water, urea, ammonia, H2O2 and glycerol. Immunocytochemical assays suggest that Aqp14 channels play important osmoregulatory roles in piscine seawater adaptation. Our data indicate that Aqp14 intracellular trafficking is tightly regulated by the vasotocinergic/isotocinergic neuropeptide and receptor systems, whereby protein kinase C and A transduction pathways phosphorylate highly conserved C-terminal residues to control channel plasma membrane insertion. The neuropeptide regulation of Aqp14 channels thus predates the vasotocin/vasopressin regulation of AQP2-5-6 orthologs observed in tetrapods. These findings demonstrate that vertebrate Aqp14 channels represent an ancient subfamily of neuropeptide-regulated polytransporters This ... |
author2 |
Ministerio de Economía y Competitividad (España) Norwegian Research Council |
format |
Article in Journal/Newspaper |
author |
Chauvigné, François Yilmaz, Ozlem Ferré, Alba Fjelldal, Per Gunnar Finn, Roderick N. Cerdà, Joan |
spellingShingle |
Chauvigné, François Yilmaz, Ozlem Ferré, Alba Fjelldal, Per Gunnar Finn, Roderick N. Cerdà, Joan The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter |
author_facet |
Chauvigné, François Yilmaz, Ozlem Ferré, Alba Fjelldal, Per Gunnar Finn, Roderick N. Cerdà, Joan |
author_sort |
Chauvigné, François |
title |
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter |
title_short |
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter |
title_full |
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter |
title_fullStr |
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter |
title_full_unstemmed |
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter |
title_sort |
vertebrate aqp14 water channel is a neuropeptide-regulated polytransporter |
publisher |
Nature Publishing Group |
publishDate |
2019 |
url |
http://hdl.handle.net/10261/342669 https://doi.org/10.1038/s42003-019-0713-y |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//RYC-2015-17103/ES/RYC-2015-17103/ info:eu-repo/grantAgreement/MINECO//BES-2014-068745/ES/BES-2014-068745/ info:eu-repo/grantAgreement/MINECO//AGL2016-76802-R Publisher's version https://doi.org/10.1038/s42003-019-0713-y No Communications Biology 2: 462 (2019) http://hdl.handle.net/10261/342669 doi:10.1038/s42003-019-0713-y 2399-3642 31840107 |
op_rights |
open |
op_doi |
https://doi.org/10.1038/s42003-019-0713-y |
container_title |
Communications Biology |
container_volume |
2 |
container_issue |
1 |
_version_ |
1790598048070500352 |