Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma
11 Pág. Microplastic (MP) pollution is an emerging contaminant in aquatic environments worldwide. Nonetheless, the developmental toxicity of MPs in the early life stages of fish and the mechanisms involved are not yet fully understood. The present study investigated the effects of different concentr...
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ftcsic:oai:digital.csic.es:10261/338955 2024-02-11T09:57:12+01:00 Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma Chen, Jincan Chen, Mengyun Fang, Chao Zheng, Ronghui Jiang, Yulu Zhang, Yusheng Wang, Kejian Bailey, Christyn Segner, Helmut Bo, Jun National Key Research and Development Program (China) National Natural Science Foundation of China Chinese Arctic and Antarctic Administration Xiamen University Chen, Jincan Chen, Mengyun Bailey, Christyn Bo, Jun 2020-09 http://hdl.handle.net/10261/338955 https://doi.org/10.1016/j.marpolbul.2020.111349 https://api.elsevier.com/content/abstract/scopus_id/85086589545 en eng Elsevier Centro de Investigación en Sanidad Animal (CISA) Publisher's version https://doi.org/10.1016/j.marpolbul.2020.111349 Sí Marine Pollution Bulletin 158: e111349 (2020) 0025-326X http://hdl.handle.net/10261/338955 doi:10.1016/j.marpolbul.2020.111349 1879-3363 32573451 2-s2.0-85086589545 https://api.elsevier.com/content/abstract/scopus_id/85086589545 open Cardiovascular toxicity Hatching rate Heart beats Immunotoxicity Inflammation artículo 2020 ftcsic https://doi.org/10.1016/j.marpolbul.2020.111349 2024-01-16T11:54:53Z 11 Pág. Microplastic (MP) pollution is an emerging contaminant in aquatic environments worldwide. Nonetheless, the developmental toxicity of MPs in the early life stages of fish and the mechanisms involved are not yet fully understood. The present study investigated the effects of different concentrations of polystyrene (PS) MPs on the early development of the marine model fish the medaka Oryzias melastigma. Our results showed that waterborne exposure to PS MPs significantly delayed the hatching time, altered the heartbeat and decreased the hatching rate of embryos. Furthermore, the genes involved in cardiac development, encoding for embryo-hatching enzymes, as well as inflammatory responses were significantly upregulated. The transcriptome results showed that mainly the pathways involved in metabolism, immune response, genetic information processing and diseases were significantly enriched. These results demonstrate that PS MPs negatively impact embryogenesis and the immune response of O. melastigma. This work was sponsored by the National Key Research and Development Program of China (No. 2019YFD0901101 ), the Scientific Research Foundation of the Third Institute of Oceanography, Ministry of Natural Resources (No. 2012019 and 2018019 ), the National Natural Science Foundation of China (No. 41977211 ), the National Program on Global Change and Air-Sea Interaction ( GASI-02-SCS-YDsum ) and the Chinese Arctic and Antarctic Administration . CB was supported SNF Post Doc Mobility Fellowship number P400PB_183824 . The authors would like to thank Chen Hui-Yun (Xiamen University) for the assistance in confocal imaging and Johanna Croton for improving the English. Peer reviewed Article in Journal/Newspaper Antarc* Antarctic Arctic Chinese Arctic and Antarctic Administration Digital.CSIC (Spanish National Research Council) Antarctic Arctic Marine Pollution Bulletin 158 111349 |
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Open Polar |
collection |
Digital.CSIC (Spanish National Research Council) |
op_collection_id |
ftcsic |
language |
English |
topic |
Cardiovascular toxicity Hatching rate Heart beats Immunotoxicity Inflammation |
spellingShingle |
Cardiovascular toxicity Hatching rate Heart beats Immunotoxicity Inflammation Chen, Jincan Chen, Mengyun Fang, Chao Zheng, Ronghui Jiang, Yulu Zhang, Yusheng Wang, Kejian Bailey, Christyn Segner, Helmut Bo, Jun Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma |
topic_facet |
Cardiovascular toxicity Hatching rate Heart beats Immunotoxicity Inflammation |
description |
11 Pág. Microplastic (MP) pollution is an emerging contaminant in aquatic environments worldwide. Nonetheless, the developmental toxicity of MPs in the early life stages of fish and the mechanisms involved are not yet fully understood. The present study investigated the effects of different concentrations of polystyrene (PS) MPs on the early development of the marine model fish the medaka Oryzias melastigma. Our results showed that waterborne exposure to PS MPs significantly delayed the hatching time, altered the heartbeat and decreased the hatching rate of embryos. Furthermore, the genes involved in cardiac development, encoding for embryo-hatching enzymes, as well as inflammatory responses were significantly upregulated. The transcriptome results showed that mainly the pathways involved in metabolism, immune response, genetic information processing and diseases were significantly enriched. These results demonstrate that PS MPs negatively impact embryogenesis and the immune response of O. melastigma. This work was sponsored by the National Key Research and Development Program of China (No. 2019YFD0901101 ), the Scientific Research Foundation of the Third Institute of Oceanography, Ministry of Natural Resources (No. 2012019 and 2018019 ), the National Natural Science Foundation of China (No. 41977211 ), the National Program on Global Change and Air-Sea Interaction ( GASI-02-SCS-YDsum ) and the Chinese Arctic and Antarctic Administration . CB was supported SNF Post Doc Mobility Fellowship number P400PB_183824 . The authors would like to thank Chen Hui-Yun (Xiamen University) for the assistance in confocal imaging and Johanna Croton for improving the English. Peer reviewed |
author2 |
National Key Research and Development Program (China) National Natural Science Foundation of China Chinese Arctic and Antarctic Administration Xiamen University Chen, Jincan Chen, Mengyun Bailey, Christyn Bo, Jun |
format |
Article in Journal/Newspaper |
author |
Chen, Jincan Chen, Mengyun Fang, Chao Zheng, Ronghui Jiang, Yulu Zhang, Yusheng Wang, Kejian Bailey, Christyn Segner, Helmut Bo, Jun |
author_facet |
Chen, Jincan Chen, Mengyun Fang, Chao Zheng, Ronghui Jiang, Yulu Zhang, Yusheng Wang, Kejian Bailey, Christyn Segner, Helmut Bo, Jun |
author_sort |
Chen, Jincan |
title |
Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma |
title_short |
Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma |
title_full |
Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma |
title_fullStr |
Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma |
title_full_unstemmed |
Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma |
title_sort |
microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka oryzias melastigma |
publisher |
Elsevier |
publishDate |
2020 |
url |
http://hdl.handle.net/10261/338955 https://doi.org/10.1016/j.marpolbul.2020.111349 https://api.elsevier.com/content/abstract/scopus_id/85086589545 |
geographic |
Antarctic Arctic |
geographic_facet |
Antarctic Arctic |
genre |
Antarc* Antarctic Arctic Chinese Arctic and Antarctic Administration |
genre_facet |
Antarc* Antarctic Arctic Chinese Arctic and Antarctic Administration |
op_relation |
Centro de Investigación en Sanidad Animal (CISA) Publisher's version https://doi.org/10.1016/j.marpolbul.2020.111349 Sí Marine Pollution Bulletin 158: e111349 (2020) 0025-326X http://hdl.handle.net/10261/338955 doi:10.1016/j.marpolbul.2020.111349 1879-3363 32573451 2-s2.0-85086589545 https://api.elsevier.com/content/abstract/scopus_id/85086589545 |
op_rights |
open |
op_doi |
https://doi.org/10.1016/j.marpolbul.2020.111349 |
container_title |
Marine Pollution Bulletin |
container_volume |
158 |
container_start_page |
111349 |
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1790609494485499904 |