HLA genes in Barranquilla (North Colombia) Searching for cryptic Amerindian genes

• Published in: Human Immunology
• Main Authors: Arnaiz-Villena, A., Bayona, B., Palacio-Gruber, J., Hernández, E., Muñiz, E., Campos, C., Juarez, I., Gómez Casado, Eduardo, Martín-Villa, J. M., Silvera, C.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2018
• Subjects: Amerindian; Colombia; HLA; Barranquilla; Caucasoid; African; Cuba; eskimo*
• Online Access: https://hdl.handle.net/20.500.12792/666; http://hdl.handle.net/10261/289987; https://doi.org/10.1016/j.humimm.2017.11.003

America First Inhabitants population (Amerindians, Na Dene and Eskimos) underwent a drastic population reduction and gene exchange after Europeans and Africans arrival after 1492 AD. Barranquilla population may be a good model to study present day population admixture in South America. HLA-A, -B and -DRB1 DNA typing has been performed in 188 unrelated individuals originated in the area and speak Spanish language; they showed apparent European/African and mixed characters. HLA genetic European/African features were found and only 1.85% Amerindian one. This contrasts with neighboring Cuban population where 10% HLA Amerindian characters appear.