The influence of climate change related factors on the response of two clam species to Diclofenac
11 pages, 6 figures, 1 table, supplementary data https://doi.org/10.1016/j.ecoenv.2019.109899 Diclofenac (DIC) is one of the non-steroidal anti-inflammatory drugs (NSAID) with higher consumption rates, used in both human and veterinary medicine. Previous studies already demonstrated the presence of...
Published in: | Ecotoxicology and Environmental Safety |
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Online Access: | http://hdl.handle.net/10261/199929 https://doi.org/10.1016/j.ecoenv.2019.109899 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100001871 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/501100011033 |
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ftcsic:oai:digital.csic.es:10261/199929 2024-02-11T10:07:37+01:00 The influence of climate change related factors on the response of two clam species to Diclofenac Costa, Silvana Coppola, Francesca Pretti, Carlo Intorre, Luigi Meucci, Valentina Soares, Amadeu M. V. M. Freitas, Rosa Solé, Montserrat Fundação para a Ciência e a Tecnologia (Portugal) European Commission Ministerio de Economía y Competitividad (España) Agencia Estatal de Investigación (España) 2020-02 http://hdl.handle.net/10261/199929 https://doi.org/10.1016/j.ecoenv.2019.109899 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100001871 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/501100011033 unknown Academic Press #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2016-76332-R Preprint https://doi.org/10.1016/j.ecoenv.2019.109899 Sí issn: 0147-6513 e-issn: 1090-2414 Ecotoxicology and Environmental Safety 189: 109899 (2020) CEX2019-000928-S http://hdl.handle.net/10261/199929 doi:10.1016/j.ecoenv.2019.109899 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100001871 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 open Pharmaceuticals Bivalves Respiration rate Metabolic capacity Oxidative stress Ruditapes clams artículo http://purl.org/coar/resource_type/c_6501 2020 ftcsic https://doi.org/10.1016/j.ecoenv.2019.10989910.13039/50110000078010.13039/50110000187110.13039/50110000332910.13039/501100011033 2024-01-16T10:48:05Z 11 pages, 6 figures, 1 table, supplementary data https://doi.org/10.1016/j.ecoenv.2019.109899 Diclofenac (DIC) is one of the non-steroidal anti-inflammatory drugs (NSAID) with higher consumption rates, used in both human and veterinary medicine. Previous studies already demonstrated the presence of this drug in aquatic environments and adverse effects towards inhabiting organisms. However, with the predictions of ocean acidification and warming, the impacts induced by DIC may differ from what is presently known and can be species-dependent. Thus, the present study aimed to comparatively assess the effects caused by DIC in the clams Ruditapes philippinarum and Ruditapes decussatus and evaluate if these impacts were influenced by pH and temperature. For this, organisms were acclimated for 30 days at two different temperature and pH (control conditions: pH 8.1, 17 °C; climate change forecasted scenario: pH 7.7, 20 °C) in the absence of drugs (experimental period I) followed by 7 days exposure under the same water physical parameters but in absence or presence of the pharmaceutical drug (at 1 μg/L, experimental period II). Biochemical responses covering metabolic capacity, oxidative stress and damage-related biomarkers were contrasted in clams at the end of the second experimental period. The results showed that under actual conditions, R. philippinarum individuals exposed to DIC presented enhanced antioxidant activities and reduced their respiration rate compared with non-contaminated clams. When exposed to the predicted climate change conditions, a similar response was observed in contaminated clams, but in this case clams increased their metabolic activities probably to fight the stress caused by the combination of both stressors. When R. decussatus was exposed to DIC, even at actual pH and temperature conditions, their antioxidant defences were also elevated but their baseline enzymatic activities were also naturally higher in respect to R. philippinarum. Although clams may use different strategies to prevent ... Article in Journal/Newspaper Ocean acidification Digital.CSIC (Spanish National Research Council) Ecotoxicology and Environmental Safety 189 109899 |
institution |
Open Polar |
collection |
Digital.CSIC (Spanish National Research Council) |
op_collection_id |
ftcsic |
language |
unknown |
topic |
Pharmaceuticals Bivalves Respiration rate Metabolic capacity Oxidative stress Ruditapes clams |
spellingShingle |
Pharmaceuticals Bivalves Respiration rate Metabolic capacity Oxidative stress Ruditapes clams Costa, Silvana Coppola, Francesca Pretti, Carlo Intorre, Luigi Meucci, Valentina Soares, Amadeu M. V. M. Freitas, Rosa Solé, Montserrat The influence of climate change related factors on the response of two clam species to Diclofenac |
topic_facet |
Pharmaceuticals Bivalves Respiration rate Metabolic capacity Oxidative stress Ruditapes clams |
description |
11 pages, 6 figures, 1 table, supplementary data https://doi.org/10.1016/j.ecoenv.2019.109899 Diclofenac (DIC) is one of the non-steroidal anti-inflammatory drugs (NSAID) with higher consumption rates, used in both human and veterinary medicine. Previous studies already demonstrated the presence of this drug in aquatic environments and adverse effects towards inhabiting organisms. However, with the predictions of ocean acidification and warming, the impacts induced by DIC may differ from what is presently known and can be species-dependent. Thus, the present study aimed to comparatively assess the effects caused by DIC in the clams Ruditapes philippinarum and Ruditapes decussatus and evaluate if these impacts were influenced by pH and temperature. For this, organisms were acclimated for 30 days at two different temperature and pH (control conditions: pH 8.1, 17 °C; climate change forecasted scenario: pH 7.7, 20 °C) in the absence of drugs (experimental period I) followed by 7 days exposure under the same water physical parameters but in absence or presence of the pharmaceutical drug (at 1 μg/L, experimental period II). Biochemical responses covering metabolic capacity, oxidative stress and damage-related biomarkers were contrasted in clams at the end of the second experimental period. The results showed that under actual conditions, R. philippinarum individuals exposed to DIC presented enhanced antioxidant activities and reduced their respiration rate compared with non-contaminated clams. When exposed to the predicted climate change conditions, a similar response was observed in contaminated clams, but in this case clams increased their metabolic activities probably to fight the stress caused by the combination of both stressors. When R. decussatus was exposed to DIC, even at actual pH and temperature conditions, their antioxidant defences were also elevated but their baseline enzymatic activities were also naturally higher in respect to R. philippinarum. Although clams may use different strategies to prevent ... |
author2 |
Fundação para a Ciência e a Tecnologia (Portugal) European Commission Ministerio de Economía y Competitividad (España) Agencia Estatal de Investigación (España) |
format |
Article in Journal/Newspaper |
author |
Costa, Silvana Coppola, Francesca Pretti, Carlo Intorre, Luigi Meucci, Valentina Soares, Amadeu M. V. M. Freitas, Rosa Solé, Montserrat |
author_facet |
Costa, Silvana Coppola, Francesca Pretti, Carlo Intorre, Luigi Meucci, Valentina Soares, Amadeu M. V. M. Freitas, Rosa Solé, Montserrat |
author_sort |
Costa, Silvana |
title |
The influence of climate change related factors on the response of two clam species to Diclofenac |
title_short |
The influence of climate change related factors on the response of two clam species to Diclofenac |
title_full |
The influence of climate change related factors on the response of two clam species to Diclofenac |
title_fullStr |
The influence of climate change related factors on the response of two clam species to Diclofenac |
title_full_unstemmed |
The influence of climate change related factors on the response of two clam species to Diclofenac |
title_sort |
influence of climate change related factors on the response of two clam species to diclofenac |
publisher |
Academic Press |
publishDate |
2020 |
url |
http://hdl.handle.net/10261/199929 https://doi.org/10.1016/j.ecoenv.2019.109899 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100001871 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/501100011033 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_relation |
#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2016-76332-R Preprint https://doi.org/10.1016/j.ecoenv.2019.109899 Sí issn: 0147-6513 e-issn: 1090-2414 Ecotoxicology and Environmental Safety 189: 109899 (2020) CEX2019-000928-S http://hdl.handle.net/10261/199929 doi:10.1016/j.ecoenv.2019.109899 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100001871 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
op_rights |
open |
op_doi |
https://doi.org/10.1016/j.ecoenv.2019.10989910.13039/50110000078010.13039/50110000187110.13039/50110000332910.13039/501100011033 |
container_title |
Ecotoxicology and Environmental Safety |
container_volume |
189 |
container_start_page |
109899 |
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1790606249790799872 |