Preparation of an Immobilized Lipase-Palladium Artificial Metalloenzyme as Catalyst in the Heck Reaction: Role of the Solid Phase

• Published in: Advanced Synthesis & Catalysis
• Main Authors: Filice, Marco, Romero, Óscar, Aires, Antonio, Guisán, José Manuel, Rumbero, Ángel, Palomo, José Miguel
• Other Authors: European Commission, Consejo Superior de Investigaciones Científicas (España), Comisión Nacional de Investigación Científica y Tecnológica (Chile)
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: John Wiley & Sons 2015
• Subjects: Lipases; Metalloenzymes; Palladium pincers; Immobilization; Romero; Antarc*; Antarctica
• Online Access: http://hdl.handle.net/10261/190471; https://doi.org/10.1002/adsc.201500014; https://doi.org/10.13039/501100000780; https://doi.org/10.13039/501100002848; https://doi.org/10.13039/501100003339

A p-nitrophenylphosphonate palladium pincer was synthesized and selectively inserted by irreversible attachment on the catalytic serine of different commercial lipases with good to excellent yields in most cases. Among all, lipase from Candida antarctica B (CAL-B) was the best modified enzyme. The a...