Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus)
et al. Previous studies have shown relationships between organohalogen contaminants (OHCs) and circulating levels of thyroid hormones (THs) in arctic wildlife. However, there is a lack of knowledge concerning the possible functional effects of OHCs on TH status in target tissues for TH-dependent act...
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Online Access: | http://hdl.handle.net/10261/125126 https://doi.org/10.1016/j.envres.2014.09.019 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/100012818 |
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ftcsic:oai:digital.csic.es:10261/125126 2024-02-11T10:00:54+01:00 Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) Møller Gabrielsen, Kristin Obregón, María Jesús Munro Jenssen, Bjørn Danish Cooperation for Environment in the Arctic Ministerio de Economía y Competitividad (España) Norwegian University of Science and Technology Comunidad de Madrid 2015 http://hdl.handle.net/10261/125126 https://doi.org/10.1016/j.envres.2014.09.019 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/100012818 unknown Elsevier #PLACEHOLDER_PARENT_METADATA_VALUE# S2010/BMD-2423/MOIR Sí doi:10.1016/j.envres.2014.09.019 issn: 0013-9351 e-issn: 1096-0953 Environmental Research 136: 413-423 (2015) http://hdl.handle.net/10261/125126 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100012818 none artículo http://purl.org/coar/resource_type/c_6501 2015 ftcsic https://doi.org/10.1016/j.envres.2014.09.01910.13039/50110000332910.13039/100012818 2024-01-16T10:11:59Z et al. Previous studies have shown relationships between organohalogen contaminants (OHCs) and circulating levels of thyroid hormones (THs) in arctic wildlife. However, there is a lack of knowledge concerning the possible functional effects of OHCs on TH status in target tissues for TH-dependent activity. The relationships between circulating (plasma) levels of OHCs and various TH variables in plasma as well as in liver, muscle and kidney tissues from East Greenland sub-adult polar bears (Ursus maritimus) sampled in 2011 (n=7) were therefore investigated. The TH variables included 3.3',5.5'-tetraiodothyronine or thyroxine (T4), 3.3',5-triiodothyronine (T3) and type 1 (D1) and type 2 (D2) deiodinase activities. Principal component analysis (PCA) combined with correlation analyses demonstrated negative relationships between individual polychlorinated biphenyls (PCBs) and their hydroxylated (OH-) metabolites and T4 in both plasma and muscle. There were both positive and negative relationships between individual OHCs and D1 and D2 activities in muscle, liver and kidney tissues. In general, PCBs, OH-PCBs and polybrominated dipehenyl ethers (PBDEs) were positively correlated to D1 and D2 activities, whereas organochlorine pesticides and byproducts (OCPs) were negatively associated with D1 and D2 activities. These results support the hypothesis that OHCs can affect TH status and action in the target tissues of polar bears. TH levels and deiodinase activities in target tissues can be sensitive endpoints for exposure of TH-disrupting compounds in arctic wildlife, and thus, tissue-specific responses in target organs should be further considered when assessing TH disruption in wildlife studies. The field work was funded by the Danish Co-operation for Environment in the Arctic (DANCEA). The analysis of thyroid hormones and deiodinase activitites in tissues was supported by research grants SAF2012-32491 from MINECO and S2010/BMD-2423 from CAM, Spain. This study was funded by NTNU. Peer Reviewed Article in Journal/Newspaper Arctic East Greenland Greenland Ursus maritimus Digital.CSIC (Spanish National Research Council) Arctic Greenland Environmental Research 136 413 423 |
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Digital.CSIC (Spanish National Research Council) |
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ftcsic |
language |
unknown |
description |
et al. Previous studies have shown relationships between organohalogen contaminants (OHCs) and circulating levels of thyroid hormones (THs) in arctic wildlife. However, there is a lack of knowledge concerning the possible functional effects of OHCs on TH status in target tissues for TH-dependent activity. The relationships between circulating (plasma) levels of OHCs and various TH variables in plasma as well as in liver, muscle and kidney tissues from East Greenland sub-adult polar bears (Ursus maritimus) sampled in 2011 (n=7) were therefore investigated. The TH variables included 3.3',5.5'-tetraiodothyronine or thyroxine (T4), 3.3',5-triiodothyronine (T3) and type 1 (D1) and type 2 (D2) deiodinase activities. Principal component analysis (PCA) combined with correlation analyses demonstrated negative relationships between individual polychlorinated biphenyls (PCBs) and their hydroxylated (OH-) metabolites and T4 in both plasma and muscle. There were both positive and negative relationships between individual OHCs and D1 and D2 activities in muscle, liver and kidney tissues. In general, PCBs, OH-PCBs and polybrominated dipehenyl ethers (PBDEs) were positively correlated to D1 and D2 activities, whereas organochlorine pesticides and byproducts (OCPs) were negatively associated with D1 and D2 activities. These results support the hypothesis that OHCs can affect TH status and action in the target tissues of polar bears. TH levels and deiodinase activities in target tissues can be sensitive endpoints for exposure of TH-disrupting compounds in arctic wildlife, and thus, tissue-specific responses in target organs should be further considered when assessing TH disruption in wildlife studies. The field work was funded by the Danish Co-operation for Environment in the Arctic (DANCEA). The analysis of thyroid hormones and deiodinase activitites in tissues was supported by research grants SAF2012-32491 from MINECO and S2010/BMD-2423 from CAM, Spain. This study was funded by NTNU. Peer Reviewed |
author2 |
Danish Cooperation for Environment in the Arctic Ministerio de Economía y Competitividad (España) Norwegian University of Science and Technology Comunidad de Madrid |
format |
Article in Journal/Newspaper |
author |
Møller Gabrielsen, Kristin Obregón, María Jesús Munro Jenssen, Bjørn |
spellingShingle |
Møller Gabrielsen, Kristin Obregón, María Jesús Munro Jenssen, Bjørn Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) |
author_facet |
Møller Gabrielsen, Kristin Obregón, María Jesús Munro Jenssen, Bjørn |
author_sort |
Møller Gabrielsen, Kristin |
title |
Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) |
title_short |
Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) |
title_full |
Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) |
title_fullStr |
Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) |
title_full_unstemmed |
Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) |
title_sort |
thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in east greenland polar bears (ursus maritimus) |
publisher |
Elsevier |
publishDate |
2015 |
url |
http://hdl.handle.net/10261/125126 https://doi.org/10.1016/j.envres.2014.09.019 https://doi.org/10.13039/501100003329 https://doi.org/10.13039/100012818 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic East Greenland Greenland Ursus maritimus |
genre_facet |
Arctic East Greenland Greenland Ursus maritimus |
op_relation |
#PLACEHOLDER_PARENT_METADATA_VALUE# S2010/BMD-2423/MOIR Sí doi:10.1016/j.envres.2014.09.019 issn: 0013-9351 e-issn: 1096-0953 Environmental Research 136: 413-423 (2015) http://hdl.handle.net/10261/125126 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100012818 |
op_rights |
none |
op_doi |
https://doi.org/10.1016/j.envres.2014.09.01910.13039/50110000332910.13039/100012818 |
container_title |
Environmental Research |
container_volume |
136 |
container_start_page |
413 |
op_container_end_page |
423 |
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1790596633084297216 |