Prehistoric genomes reveal the genetic foundation and cost of horse domestication
Schubert, Michael et al. The domestication of the horse ∼5.5 kya and the emergence of mounted riding, chariotry, and cavalry dramatically transformed human civilization. However, the genetics underlying horse domestication are difficult to reconstruct, given the near extinction of wild horses. We th...
Published in: | Proceedings of the National Academy of Sciences |
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Main Authors: | , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
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National Academy of Sciences (U.S.)
2014
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Online Access: | http://hdl.handle.net/10261/115530 https://doi.org/10.1073/pnas.1416991111 https://doi.org/10.13039/100005595 https://doi.org/10.13039/501100001732 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100004837 https://doi.org/10.13039/501100002383 https://doi.org/10.13039/501100003554 https://doi.org/10.13039/501100000781 https://doi.org/10.13039/100000008 |
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Digital.CSIC (Spanish National Research Council) |
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ftcsic |
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English |
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Ancient DNA Horse domestication Przewalski’s horse Positive selection Cost of domestication |
spellingShingle |
Ancient DNA Horse domestication Przewalski’s horse Positive selection Cost of domestication Schubert, Michael Marqués-Bonet, Tomàs Orlando, Ludovic Prehistoric genomes reveal the genetic foundation and cost of horse domestication |
topic_facet |
Ancient DNA Horse domestication Przewalski’s horse Positive selection Cost of domestication |
description |
Schubert, Michael et al. The domestication of the horse ∼5.5 kya and the emergence of mounted riding, chariotry, and cavalry dramatically transformed human civilization. However, the genetics underlying horse domestication are difficult to reconstruct, given the near extinction of wild horses. We therefore sequenced two ancient horse genomes from Taymyr, Russia (at 7.4- and 24.3-fold coverage), both predating the earliest archeological evidence of domestication. We compared these genomes with genomes of domesticated horses and the wild Przewalski's horse and found genetic structure within Eurasia in the Late Pleistocene, with the ancient population contributing significantly to the genetic variation of domesticated breeds. We furthermore identified a conservative set of 125 potential domestication targets using four complementary scans for genes that have undergone positive selection. One group of genes is involved in muscular and limb development, articular junctions, and the cardiac system, and may represent physiological adaptations to human utilization. A second group consists of genes with cognitive functions, including social behavior, learning capabilities, fear response, and agreeableness, which may have been key for taming horses. We also found that domestication is associated with inbreeding and an excess of deleterious mutations. This genetic load is in line with the "cost of domestication" hypothesis also reported for rice, tomatoes, and dogs, and it is generally attributed to the relaxation of purifying selection resulting from the strong demographic bottlenecks accompanying domestication. Our work demonstrates the power of ancient genomes to reconstruct the complex genetic changes that transformed wild animals into their domesticated forms, and the population context in which this process took place. © 2014, National Academy of Sciences. All rights reserved. This work was supported by the Danish Council for Independent Research, Natural Sciences (FNU); the Danish National Research Foundation ... |
author2 |
University of California Danish Council for Independent Research Danish National Research Foundation European Commission Ministerio de Ciencia e Innovación (España) King Saud University Lundbeck Foundation Swiss National Science Foundation European Research Council David and Lucile Packard Foundation |
format |
Article in Journal/Newspaper |
author |
Schubert, Michael Marqués-Bonet, Tomàs Orlando, Ludovic |
author_facet |
Schubert, Michael Marqués-Bonet, Tomàs Orlando, Ludovic |
author_sort |
Schubert, Michael |
title |
Prehistoric genomes reveal the genetic foundation and cost of horse domestication |
title_short |
Prehistoric genomes reveal the genetic foundation and cost of horse domestication |
title_full |
Prehistoric genomes reveal the genetic foundation and cost of horse domestication |
title_fullStr |
Prehistoric genomes reveal the genetic foundation and cost of horse domestication |
title_full_unstemmed |
Prehistoric genomes reveal the genetic foundation and cost of horse domestication |
title_sort |
prehistoric genomes reveal the genetic foundation and cost of horse domestication |
publisher |
National Academy of Sciences (U.S.) |
publishDate |
2014 |
url |
http://hdl.handle.net/10261/115530 https://doi.org/10.1073/pnas.1416991111 https://doi.org/10.13039/100005595 https://doi.org/10.13039/501100001732 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100004837 https://doi.org/10.13039/501100002383 https://doi.org/10.13039/501100003554 https://doi.org/10.13039/501100000781 https://doi.org/10.13039/100000008 |
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ENVELOPE(8.308,8.308,63.772,63.772) ENVELOPE(89.987,89.987,68.219,68.219) |
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Kya Taymyr |
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Kya Taymyr |
genre |
Taymyr |
genre_facet |
Taymyr |
op_relation |
http://dx.doi.org/10.1073/pnas.1416991111 Sí Proceedings of the National Academy of Sciences 111(52): E5661- E5669 (2014) 1091-6490 http://hdl.handle.net/10261/115530 doi:10.1073/pnas.1416991111 http://dx.doi.org/10.13039/100005595 http://dx.doi.org/10.13039/501100001732 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100002383 http://dx.doi.org/10.13039/501100003554 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/100000008 25512547 |
op_rights |
none |
op_doi |
https://doi.org/10.1073/pnas.141699111110.13039/10000559510.13039/50110000173210.13039/50110000078010.13039/50110000483710.13039/50110000238310.13039/50110000355410.13039/50110000078110.13039/100000008 |
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Proceedings of the National Academy of Sciences |
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111 |
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52 |
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E5661 |
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E5669 |
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spelling |
ftcsic:oai:digital.csic.es:10261/115530 2024-02-11T10:09:05+01:00 Prehistoric genomes reveal the genetic foundation and cost of horse domestication Schubert, Michael Marqués-Bonet, Tomàs Orlando, Ludovic University of California Danish Council for Independent Research Danish National Research Foundation European Commission Ministerio de Ciencia e Innovación (España) King Saud University Lundbeck Foundation Swiss National Science Foundation European Research Council David and Lucile Packard Foundation 2014-11-30 http://hdl.handle.net/10261/115530 https://doi.org/10.1073/pnas.1416991111 https://doi.org/10.13039/100005595 https://doi.org/10.13039/501100001732 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100004837 https://doi.org/10.13039/501100002383 https://doi.org/10.13039/501100003554 https://doi.org/10.13039/501100000781 https://doi.org/10.13039/100000008 en eng National Academy of Sciences (U.S.) http://dx.doi.org/10.1073/pnas.1416991111 Sí Proceedings of the National Academy of Sciences 111(52): E5661- E5669 (2014) 1091-6490 http://hdl.handle.net/10261/115530 doi:10.1073/pnas.1416991111 http://dx.doi.org/10.13039/100005595 http://dx.doi.org/10.13039/501100001732 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100002383 http://dx.doi.org/10.13039/501100003554 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/100000008 25512547 none Ancient DNA Horse domestication Przewalski’s horse Positive selection Cost of domestication artículo http://purl.org/coar/resource_type/c_6501 2014 ftcsic https://doi.org/10.1073/pnas.141699111110.13039/10000559510.13039/50110000173210.13039/50110000078010.13039/50110000483710.13039/50110000238310.13039/50110000355410.13039/50110000078110.13039/100000008 2024-01-16T10:07:27Z Schubert, Michael et al. The domestication of the horse ∼5.5 kya and the emergence of mounted riding, chariotry, and cavalry dramatically transformed human civilization. However, the genetics underlying horse domestication are difficult to reconstruct, given the near extinction of wild horses. We therefore sequenced two ancient horse genomes from Taymyr, Russia (at 7.4- and 24.3-fold coverage), both predating the earliest archeological evidence of domestication. We compared these genomes with genomes of domesticated horses and the wild Przewalski's horse and found genetic structure within Eurasia in the Late Pleistocene, with the ancient population contributing significantly to the genetic variation of domesticated breeds. We furthermore identified a conservative set of 125 potential domestication targets using four complementary scans for genes that have undergone positive selection. One group of genes is involved in muscular and limb development, articular junctions, and the cardiac system, and may represent physiological adaptations to human utilization. A second group consists of genes with cognitive functions, including social behavior, learning capabilities, fear response, and agreeableness, which may have been key for taming horses. We also found that domestication is associated with inbreeding and an excess of deleterious mutations. This genetic load is in line with the "cost of domestication" hypothesis also reported for rice, tomatoes, and dogs, and it is generally attributed to the relaxation of purifying selection resulting from the strong demographic bottlenecks accompanying domestication. Our work demonstrates the power of ancient genomes to reconstruct the complex genetic changes that transformed wild animals into their domesticated forms, and the population context in which this process took place. © 2014, National Academy of Sciences. All rights reserved. This work was supported by the Danish Council for Independent Research, Natural Sciences (FNU); the Danish National Research Foundation ... Article in Journal/Newspaper Taymyr Digital.CSIC (Spanish National Research Council) Kya ENVELOPE(8.308,8.308,63.772,63.772) Taymyr ENVELOPE(89.987,89.987,68.219,68.219) Proceedings of the National Academy of Sciences 111 52 E5661 E5669 |