Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage
Due to the grasshopper effect, the Arctic food chain in Canada is contaminated with persistent organic pollutants (POPs) of industrial origin, including polychlorinated biphenyls and organochlorine pesticides. Exposure to POPs may be a contributor to the greater incidence of poor fetal growth, place...
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Online Access: | https://repository.cshl.edu/id/eprint/40252/ https://repository.cshl.edu/id/eprint/40252/1/2021.Maurice.sperm_epigenome.pdf https://doi.org/10.3390/epigenomes5020010 |
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ftcshl:oai:repository.cshl.edu:40252 2024-02-27T08:37:52+00:00 Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage Maurice, C Dalvai, M Lambrot, R Deschênes, A Scott-Boyer, MP McGraw, S Chan, D Côté, N Ziv-Gal, A Flaws, JA Droit, A Trasler, J Kimmins, S Bailey, JL 2021-06-01 application/pdf https://repository.cshl.edu/id/eprint/40252/ https://repository.cshl.edu/id/eprint/40252/1/2021.Maurice.sperm_epigenome.pdf https://doi.org/10.3390/epigenomes5020010 en eng https://repository.cshl.edu/id/eprint/40252/1/2021.Maurice.sperm_epigenome.pdf Maurice, C, Dalvai, M, Lambrot, R, Deschênes, A, Scott-Boyer, MP, McGraw, S, Chan, D, Côté, N, Ziv-Gal, A, Flaws, JA, Droit, A, Trasler, J, Kimmins, S, Bailey, JL (June 2021) Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage. Epigenomes, 5 (2). p. 10. ISSN 2075-4655 doi:10.3390/epigenomes5020010 cc_by bioinformatics DNA RNA structure function modification genetics & nucleic acid processing genomics and proteomics epigenetics pregnancy Paper PeerReviewed 2021 ftcshl https://doi.org/10.3390/epigenomes5020010 2024-01-28T04:07:30Z Due to the grasshopper effect, the Arctic food chain in Canada is contaminated with persistent organic pollutants (POPs) of industrial origin, including polychlorinated biphenyls and organochlorine pesticides. Exposure to POPs may be a contributor to the greater incidence of poor fetal growth, placental abnormalities, stillbirths, congenital defects and shortened lifespan in the Inuit population compared to non-Aboriginal Canadians. Although maternal exposure to POPs is well established to harm pregnancy outcomes, paternal transmission of the effects of POPs is a possibility that has not been well investigated. We used a rat model to test the hypothesis that exposure to POPs during gestation and suckling leads to developmental defects that are transmitted to subsequent generations via the male lineage. Indeed, developmental exposure to an environmentally relevant Arctic POPs mixture impaired sperm quality and pregnancy outcomes across two subsequent, unexposed generations and altered sperm DNA methylation, some of which are also observed for two additional generations. Genes corresponding to the altered sperm methylome correspond to health problems encountered in the Inuit population. These findings demonstrate that the paternal methylome is sensitive to the environment and that some perturbations persist for at least two subsequent generations. In conclusion, although many factors influence health, paternal exposure to contaminants plays a heretofore-underappreciated role with sperm DNA methylation contributing to the molecular underpinnings involved. Report Arctic inuit Cold Spring Harbor Laboratory: CSHL Institutional Repository Arctic Canada Epigenomes 5 2 10 |
institution |
Open Polar |
collection |
Cold Spring Harbor Laboratory: CSHL Institutional Repository |
op_collection_id |
ftcshl |
language |
English |
topic |
bioinformatics DNA RNA structure function modification genetics & nucleic acid processing genomics and proteomics epigenetics pregnancy |
spellingShingle |
bioinformatics DNA RNA structure function modification genetics & nucleic acid processing genomics and proteomics epigenetics pregnancy Maurice, C Dalvai, M Lambrot, R Deschênes, A Scott-Boyer, MP McGraw, S Chan, D Côté, N Ziv-Gal, A Flaws, JA Droit, A Trasler, J Kimmins, S Bailey, JL Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage |
topic_facet |
bioinformatics DNA RNA structure function modification genetics & nucleic acid processing genomics and proteomics epigenetics pregnancy |
description |
Due to the grasshopper effect, the Arctic food chain in Canada is contaminated with persistent organic pollutants (POPs) of industrial origin, including polychlorinated biphenyls and organochlorine pesticides. Exposure to POPs may be a contributor to the greater incidence of poor fetal growth, placental abnormalities, stillbirths, congenital defects and shortened lifespan in the Inuit population compared to non-Aboriginal Canadians. Although maternal exposure to POPs is well established to harm pregnancy outcomes, paternal transmission of the effects of POPs is a possibility that has not been well investigated. We used a rat model to test the hypothesis that exposure to POPs during gestation and suckling leads to developmental defects that are transmitted to subsequent generations via the male lineage. Indeed, developmental exposure to an environmentally relevant Arctic POPs mixture impaired sperm quality and pregnancy outcomes across two subsequent, unexposed generations and altered sperm DNA methylation, some of which are also observed for two additional generations. Genes corresponding to the altered sperm methylome correspond to health problems encountered in the Inuit population. These findings demonstrate that the paternal methylome is sensitive to the environment and that some perturbations persist for at least two subsequent generations. In conclusion, although many factors influence health, paternal exposure to contaminants plays a heretofore-underappreciated role with sperm DNA methylation contributing to the molecular underpinnings involved. |
format |
Report |
author |
Maurice, C Dalvai, M Lambrot, R Deschênes, A Scott-Boyer, MP McGraw, S Chan, D Côté, N Ziv-Gal, A Flaws, JA Droit, A Trasler, J Kimmins, S Bailey, JL |
author_facet |
Maurice, C Dalvai, M Lambrot, R Deschênes, A Scott-Boyer, MP McGraw, S Chan, D Côté, N Ziv-Gal, A Flaws, JA Droit, A Trasler, J Kimmins, S Bailey, JL |
author_sort |
Maurice, C |
title |
Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage |
title_short |
Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage |
title_full |
Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage |
title_fullStr |
Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage |
title_full_unstemmed |
Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage |
title_sort |
early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage |
publishDate |
2021 |
url |
https://repository.cshl.edu/id/eprint/40252/ https://repository.cshl.edu/id/eprint/40252/1/2021.Maurice.sperm_epigenome.pdf https://doi.org/10.3390/epigenomes5020010 |
geographic |
Arctic Canada |
geographic_facet |
Arctic Canada |
genre |
Arctic inuit |
genre_facet |
Arctic inuit |
op_relation |
https://repository.cshl.edu/id/eprint/40252/1/2021.Maurice.sperm_epigenome.pdf Maurice, C, Dalvai, M, Lambrot, R, Deschênes, A, Scott-Boyer, MP, McGraw, S, Chan, D, Côté, N, Ziv-Gal, A, Flaws, JA, Droit, A, Trasler, J, Kimmins, S, Bailey, JL (June 2021) Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage. Epigenomes, 5 (2). p. 10. ISSN 2075-4655 doi:10.3390/epigenomes5020010 |
op_rights |
cc_by |
op_doi |
https://doi.org/10.3390/epigenomes5020010 |
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Epigenomes |
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5 |
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10 |
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1792044804507435008 |