Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years
Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark,...
Published in: | Journal of Clinical Microbiology |
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2012
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Online Access: | https://curis.ku.dk/portal/da/publications/clustered-tuberculosis-in-a-lowburden-country(ffcf580b-5e2d-4d44-9d85-1b13cf631729).html https://doi.org/10.1128/JCM.06358-11 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/ffcf580b-5e2d-4d44-9d85-1b13cf631729 2023-05-15T16:30:58+02:00 Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years Kamper-Jørgensen, Z Andersen, A B Kok-Jensen, A Bygbjerg, I C Andersen, P H Thomsen, V O Kamper-Jørgensen, Mads Lillebaek, T 2012 https://curis.ku.dk/portal/da/publications/clustered-tuberculosis-in-a-lowburden-country(ffcf580b-5e2d-4d44-9d85-1b13cf631729).html https://doi.org/10.1128/JCM.06358-11 eng eng info:eu-repo/semantics/restrictedAccess Kamper-Jørgensen , Z , Andersen , A B , Kok-Jensen , A , Bygbjerg , I C , Andersen , P H , Thomsen , V O , Kamper-Jørgensen , M & Lillebaek , T 2012 , ' Clustered tuberculosis in a low-burden country : nationwide genotyping through 15 years ' , Journal of Clinical Microbiology , vol. 50 , no. 8 , pp. 2660-2667 . https://doi.org/10.1128/JCM.06358-11 Adolescent Adult Aged 80 and over Child Preschool Cluster Analysis DNA Transposable Elements DNA Bacterial Denmark Female Genotype Humans Infant Newborn Male Middle Aged Molecular Epidemiology Molecular Typing Mycobacterium tuberculosis Polymorphism Restriction Fragment Length Retrospective Studies Tuberculosis Young Adult article 2012 ftcopenhagenunip https://doi.org/10.1128/JCM.06358-11 2021-10-06T22:54:46Z Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark, a country on the way toward tuberculosis elimination, we discuss M. tuberculosis transmission dynamics and point to areas for control interventions. Cases with 100% identical genotypes (RFLP patterns) were defined as clustered, and a cluster was defined as cases with an identical genotype. Of 4,601 included cases, corresponding to 76% of reported and 97% of culture-verified tuberculosis cases in the country, 56% were clustered, of which 69% were Danes. Generally, Danes were more often in large clusters (= 50 persons), older (mean age, 45 years), and male (male/female ratio, 2.5). Also, Danes had a higher cluster frequency within a 2-year observation window (60.8%), and higher clustering rate of new patterns over time, compared to immigrants. A dominant genotype, cluster 2, constituted 44% of all clustered and 35% of all genotyped cases. This cluster was primarily found among Danish males, 30 to 59 years of age, often socially marginalized, and with records of alcohol abuse. In Danes, cluster 2 alone was responsible for the high cluster frequency level. Immigrants had a higher incidence of clustered tuberculosis at a younger age (0 to 39 years). To achieve tuberculosis elimination in Denmark, high-risk transmission environments, like the cluster 2 environment in Danes, and specific transmission chains in immigrants in the capital area, e.g., homeless/socially marginalized Somalis/Greenlanders, often with alcohol abuse, must be targeted, including groups with a high risk of reactivation. Article in Journal/Newspaper greenlander* University of Copenhagen: Research Journal of Clinical Microbiology 50 8 2660 2667 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Adolescent Adult Aged 80 and over Child Preschool Cluster Analysis DNA Transposable Elements DNA Bacterial Denmark Female Genotype Humans Infant Newborn Male Middle Aged Molecular Epidemiology Molecular Typing Mycobacterium tuberculosis Polymorphism Restriction Fragment Length Retrospective Studies Tuberculosis Young Adult |
spellingShingle |
Adolescent Adult Aged 80 and over Child Preschool Cluster Analysis DNA Transposable Elements DNA Bacterial Denmark Female Genotype Humans Infant Newborn Male Middle Aged Molecular Epidemiology Molecular Typing Mycobacterium tuberculosis Polymorphism Restriction Fragment Length Retrospective Studies Tuberculosis Young Adult Kamper-Jørgensen, Z Andersen, A B Kok-Jensen, A Bygbjerg, I C Andersen, P H Thomsen, V O Kamper-Jørgensen, Mads Lillebaek, T Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years |
topic_facet |
Adolescent Adult Aged 80 and over Child Preschool Cluster Analysis DNA Transposable Elements DNA Bacterial Denmark Female Genotype Humans Infant Newborn Male Middle Aged Molecular Epidemiology Molecular Typing Mycobacterium tuberculosis Polymorphism Restriction Fragment Length Retrospective Studies Tuberculosis Young Adult |
description |
Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark, a country on the way toward tuberculosis elimination, we discuss M. tuberculosis transmission dynamics and point to areas for control interventions. Cases with 100% identical genotypes (RFLP patterns) were defined as clustered, and a cluster was defined as cases with an identical genotype. Of 4,601 included cases, corresponding to 76% of reported and 97% of culture-verified tuberculosis cases in the country, 56% were clustered, of which 69% were Danes. Generally, Danes were more often in large clusters (= 50 persons), older (mean age, 45 years), and male (male/female ratio, 2.5). Also, Danes had a higher cluster frequency within a 2-year observation window (60.8%), and higher clustering rate of new patterns over time, compared to immigrants. A dominant genotype, cluster 2, constituted 44% of all clustered and 35% of all genotyped cases. This cluster was primarily found among Danish males, 30 to 59 years of age, often socially marginalized, and with records of alcohol abuse. In Danes, cluster 2 alone was responsible for the high cluster frequency level. Immigrants had a higher incidence of clustered tuberculosis at a younger age (0 to 39 years). To achieve tuberculosis elimination in Denmark, high-risk transmission environments, like the cluster 2 environment in Danes, and specific transmission chains in immigrants in the capital area, e.g., homeless/socially marginalized Somalis/Greenlanders, often with alcohol abuse, must be targeted, including groups with a high risk of reactivation. |
format |
Article in Journal/Newspaper |
author |
Kamper-Jørgensen, Z Andersen, A B Kok-Jensen, A Bygbjerg, I C Andersen, P H Thomsen, V O Kamper-Jørgensen, Mads Lillebaek, T |
author_facet |
Kamper-Jørgensen, Z Andersen, A B Kok-Jensen, A Bygbjerg, I C Andersen, P H Thomsen, V O Kamper-Jørgensen, Mads Lillebaek, T |
author_sort |
Kamper-Jørgensen, Z |
title |
Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years |
title_short |
Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years |
title_full |
Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years |
title_fullStr |
Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years |
title_full_unstemmed |
Clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years |
title_sort |
clustered tuberculosis in a low-burden country:nationwide genotyping through 15 years |
publishDate |
2012 |
url |
https://curis.ku.dk/portal/da/publications/clustered-tuberculosis-in-a-lowburden-country(ffcf580b-5e2d-4d44-9d85-1b13cf631729).html https://doi.org/10.1128/JCM.06358-11 |
genre |
greenlander* |
genre_facet |
greenlander* |
op_source |
Kamper-Jørgensen , Z , Andersen , A B , Kok-Jensen , A , Bygbjerg , I C , Andersen , P H , Thomsen , V O , Kamper-Jørgensen , M & Lillebaek , T 2012 , ' Clustered tuberculosis in a low-burden country : nationwide genotyping through 15 years ' , Journal of Clinical Microbiology , vol. 50 , no. 8 , pp. 2660-2667 . https://doi.org/10.1128/JCM.06358-11 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1128/JCM.06358-11 |
container_title |
Journal of Clinical Microbiology |
container_volume |
50 |
container_issue |
8 |
container_start_page |
2660 |
op_container_end_page |
2667 |
_version_ |
1766020787060342784 |