Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa
Most multicellular animals belong to two evolutionary lineages, the Proto- and Deuterostomia, which diverged 640-760 million years (MYR) ago. Neuropeptide signaling is abundant in animals belonging to both lineages, but it is often unclear whether there exist evolutionary relationships between the n...
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ftcopenhagenunip:oai:pure.atira.dk:publications/f941b5e3-a56b-4999-b9c5-18123ba9779e 2024-05-12T08:02:44+00:00 Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa Li, Shizhong Hauser, Frank Skadborg, Signe K. Nielsen, Stine Vang Kirketerp-Møller, Nikolaj Grimmelikhuijzen, Cornelis 2016 application/pdf https://curis.ku.dk/portal/da/publications/adipokinetic-hormones-and-their-g-proteincoupled-receptors-emerged-in-lophotrochozoa(f941b5e3-a56b-4999-b9c5-18123ba9779e).html https://doi.org/10.1038/srep32789 https://curis.ku.dk/ws/files/165747953/Adipokinetic_hormones_and_their.pdf eng eng info:eu-repo/semantics/openAccess Li , S , Hauser , F , Skadborg , S K , Nielsen , S V , Kirketerp-Møller , N & Grimmelikhuijzen , C 2016 , ' Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa ' , Scientific Reports , vol. 6 , 32789 . https://doi.org/10.1038/srep32789 article 2016 ftcopenhagenunip https://doi.org/10.1038/srep32789 2024-04-18T00:28:13Z Most multicellular animals belong to two evolutionary lineages, the Proto- and Deuterostomia, which diverged 640-760 million years (MYR) ago. Neuropeptide signaling is abundant in animals belonging to both lineages, but it is often unclear whether there exist evolutionary relationships between the neuropeptide systems used by proto- or deuterostomes. An exception, however, are members of the gonadotropin-releasing hormone (GnRH) receptor superfamily, which occur in both evolutionary lineages, where GnRHs are the ligands in Deuterostomia and GnRH-like peptides, adipokinetic hormone (AKH), corazonin, and AKH/corazonin-related peptide (ACP) are the ligands in Protostomia. AKH is a well-studied insect neuropeptide that mobilizes lipids and carbohydrates from the insect fat body during flight. In our present paper, we show that AKH is not only widespread in insects, but also in other Ecdysozoa and in Lophotrochozoa. Furthermore, we have cloned and deorphanized two G protein-coupled receptors (GPCRs) from the oyster Crassostrea gigas (Mollusca) that are activated by low nanomolar concentrations of oyster AKH (pQVSFSTNWGSamide). Our discovery of functional AKH receptors in molluscs is especially significant, because it traces the emergence of AKH signaling back to about 550 MYR ago and brings us closer to a more complete understanding of the evolutionary origins of the GnRH receptor superfamily. Article in Journal/Newspaper Crassostrea gigas University of Copenhagen: Research Scientific Reports 6 1 |
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Open Polar |
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University of Copenhagen: Research |
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ftcopenhagenunip |
language |
English |
description |
Most multicellular animals belong to two evolutionary lineages, the Proto- and Deuterostomia, which diverged 640-760 million years (MYR) ago. Neuropeptide signaling is abundant in animals belonging to both lineages, but it is often unclear whether there exist evolutionary relationships between the neuropeptide systems used by proto- or deuterostomes. An exception, however, are members of the gonadotropin-releasing hormone (GnRH) receptor superfamily, which occur in both evolutionary lineages, where GnRHs are the ligands in Deuterostomia and GnRH-like peptides, adipokinetic hormone (AKH), corazonin, and AKH/corazonin-related peptide (ACP) are the ligands in Protostomia. AKH is a well-studied insect neuropeptide that mobilizes lipids and carbohydrates from the insect fat body during flight. In our present paper, we show that AKH is not only widespread in insects, but also in other Ecdysozoa and in Lophotrochozoa. Furthermore, we have cloned and deorphanized two G protein-coupled receptors (GPCRs) from the oyster Crassostrea gigas (Mollusca) that are activated by low nanomolar concentrations of oyster AKH (pQVSFSTNWGSamide). Our discovery of functional AKH receptors in molluscs is especially significant, because it traces the emergence of AKH signaling back to about 550 MYR ago and brings us closer to a more complete understanding of the evolutionary origins of the GnRH receptor superfamily. |
format |
Article in Journal/Newspaper |
author |
Li, Shizhong Hauser, Frank Skadborg, Signe K. Nielsen, Stine Vang Kirketerp-Møller, Nikolaj Grimmelikhuijzen, Cornelis |
spellingShingle |
Li, Shizhong Hauser, Frank Skadborg, Signe K. Nielsen, Stine Vang Kirketerp-Møller, Nikolaj Grimmelikhuijzen, Cornelis Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa |
author_facet |
Li, Shizhong Hauser, Frank Skadborg, Signe K. Nielsen, Stine Vang Kirketerp-Møller, Nikolaj Grimmelikhuijzen, Cornelis |
author_sort |
Li, Shizhong |
title |
Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa |
title_short |
Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa |
title_full |
Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa |
title_fullStr |
Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa |
title_full_unstemmed |
Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa |
title_sort |
adipokinetic hormones and their g protein-coupled receptors emerged in lophotrochozoa |
publishDate |
2016 |
url |
https://curis.ku.dk/portal/da/publications/adipokinetic-hormones-and-their-g-proteincoupled-receptors-emerged-in-lophotrochozoa(f941b5e3-a56b-4999-b9c5-18123ba9779e).html https://doi.org/10.1038/srep32789 https://curis.ku.dk/ws/files/165747953/Adipokinetic_hormones_and_their.pdf |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Li , S , Hauser , F , Skadborg , S K , Nielsen , S V , Kirketerp-Møller , N & Grimmelikhuijzen , C 2016 , ' Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa ' , Scientific Reports , vol. 6 , 32789 . https://doi.org/10.1038/srep32789 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/srep32789 |
container_title |
Scientific Reports |
container_volume |
6 |
container_issue |
1 |
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1798844882480005120 |