Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland
Background: Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids. Objectives: To assess the association betwee...
Published in: | Atherosclerosis |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2013
|
Subjects: | |
Online Access: | https://curis.ku.dk/portal/da/publications/intake-of-traditional-inuit-diet-vary-in-parallel-with-inflammation-as-estimated-from-ykl40-and-hscrp-in-inuit-and-noninuit-in-greenland(f10aa245-92ec-48be-bbeb-276c4866fc02).html https://doi.org/10.1016/j.atherosclerosis.2013.03.022 |
id |
ftcopenhagenunip:oai:pure.atira.dk:publications/f10aa245-92ec-48be-bbeb-276c4866fc02 |
---|---|
record_format |
openpolar |
spelling |
ftcopenhagenunip:oai:pure.atira.dk:publications/f10aa245-92ec-48be-bbeb-276c4866fc02 2024-02-27T08:38:25+00:00 Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland Schæbel, Louise Holm Vestergaard, H Laurberg, Peter Marvin Rathcke, C N Andersen, S 2013-06 https://curis.ku.dk/portal/da/publications/intake-of-traditional-inuit-diet-vary-in-parallel-with-inflammation-as-estimated-from-ykl40-and-hscrp-in-inuit-and-noninuit-in-greenland(f10aa245-92ec-48be-bbeb-276c4866fc02).html https://doi.org/10.1016/j.atherosclerosis.2013.03.022 eng eng info:eu-repo/semantics/restrictedAccess Schæbel , L H , Vestergaard , H , Laurberg , P M , Rathcke , C N & Andersen , S 2013 , ' Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland ' , Atherosclerosis , vol. 228 , no. 2 , pp. 496-501 . https://doi.org/10.1016/j.atherosclerosis.2013.03.022 Adipokines Aged Biological Markers C-Reactive Protein Cardiovascular Diseases Diet Female Greenland Humans Inflammation Inflammation Mediators Inuits Lectins Male Middle Aged Risk Assessment Risk Factors article 2013 ftcopenhagenunip https://doi.org/10.1016/j.atherosclerosis.2013.03.022 2024-02-01T00:02:24Z Background: Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids. Objectives: To assess the association between biomarkers of inflammation and the intake of traditional Inuit diet in addition to Inuit ethnicity. Methods: YKL-40 and hsCRP was measured in serum from 535 Inuit and non-Inuit living in the capital city Nuuk in West Greenland or in the main town or a settlement in rural East Greenland. Dietary habits were assessed by an interview-based food frequency questionnaire. Results: The participation rate was 95%. YKL-40 was higher in Inuit than in non-Inuit (p<0.001), in Inuit with a higher intake of traditional Inuit diet (p<0.001), and in Inuit from rural compared to urban areas (p<0.001). It also rose with age (p<0.001), alcohol intake (0.019) and smoking (p<0.001). Inuit had higher hsCRP compared to non-Inuit (p=0.003) and hsCRP increased in parallel with intake of traditional Inuit foods (p<0.001). Alcohol associated with a decrease in hsCRP in Inuit (p=0.004). YKL-40 and hsCRP increased with higher intakes of traditional Inuit diet after adjusting for ethnicity, gender, age, smoking, alcohol intake and BMI. Conclusions: Biomarkers of inflammation vary in parallel with the intake of traditional Inuit diet. A diet based on marine mammals from the Arctic does not reduce inflammatory activity and markers of inflammation may thus reflect the disease rather than the cause of the disease Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids. Article in Journal/Newspaper Arctic East Greenland Greenland inuit inuits Nuuk University of Copenhagen: Research Arctic Greenland Nuuk ENVELOPE(-52.150,-52.150,68.717,68.717) Atherosclerosis 228 2 496 501 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Adipokines Aged Biological Markers C-Reactive Protein Cardiovascular Diseases Diet Female Greenland Humans Inflammation Inflammation Mediators Inuits Lectins Male Middle Aged Risk Assessment Risk Factors |
spellingShingle |
Adipokines Aged Biological Markers C-Reactive Protein Cardiovascular Diseases Diet Female Greenland Humans Inflammation Inflammation Mediators Inuits Lectins Male Middle Aged Risk Assessment Risk Factors Schæbel, Louise Holm Vestergaard, H Laurberg, Peter Marvin Rathcke, C N Andersen, S Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland |
topic_facet |
Adipokines Aged Biological Markers C-Reactive Protein Cardiovascular Diseases Diet Female Greenland Humans Inflammation Inflammation Mediators Inuits Lectins Male Middle Aged Risk Assessment Risk Factors |
description |
Background: Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids. Objectives: To assess the association between biomarkers of inflammation and the intake of traditional Inuit diet in addition to Inuit ethnicity. Methods: YKL-40 and hsCRP was measured in serum from 535 Inuit and non-Inuit living in the capital city Nuuk in West Greenland or in the main town or a settlement in rural East Greenland. Dietary habits were assessed by an interview-based food frequency questionnaire. Results: The participation rate was 95%. YKL-40 was higher in Inuit than in non-Inuit (p<0.001), in Inuit with a higher intake of traditional Inuit diet (p<0.001), and in Inuit from rural compared to urban areas (p<0.001). It also rose with age (p<0.001), alcohol intake (0.019) and smoking (p<0.001). Inuit had higher hsCRP compared to non-Inuit (p=0.003) and hsCRP increased in parallel with intake of traditional Inuit foods (p<0.001). Alcohol associated with a decrease in hsCRP in Inuit (p=0.004). YKL-40 and hsCRP increased with higher intakes of traditional Inuit diet after adjusting for ethnicity, gender, age, smoking, alcohol intake and BMI. Conclusions: Biomarkers of inflammation vary in parallel with the intake of traditional Inuit diet. A diet based on marine mammals from the Arctic does not reduce inflammatory activity and markers of inflammation may thus reflect the disease rather than the cause of the disease Chronic low-grade inflammation is involved in the initiation and progression of atherosclerosis and ischemic heart disease. This was rare in pre-western Inuit who lived on a diet that consisted mainly of marine mammals rich in n-3 fatty acids. |
format |
Article in Journal/Newspaper |
author |
Schæbel, Louise Holm Vestergaard, H Laurberg, Peter Marvin Rathcke, C N Andersen, S |
author_facet |
Schæbel, Louise Holm Vestergaard, H Laurberg, Peter Marvin Rathcke, C N Andersen, S |
author_sort |
Schæbel, Louise Holm |
title |
Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland |
title_short |
Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland |
title_full |
Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland |
title_fullStr |
Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland |
title_full_unstemmed |
Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland |
title_sort |
intake of traditional inuit diet vary in parallel with inflammation as estimated from ykl-40 and hscrp in inuit and non-inuit in greenland |
publishDate |
2013 |
url |
https://curis.ku.dk/portal/da/publications/intake-of-traditional-inuit-diet-vary-in-parallel-with-inflammation-as-estimated-from-ykl40-and-hscrp-in-inuit-and-noninuit-in-greenland(f10aa245-92ec-48be-bbeb-276c4866fc02).html https://doi.org/10.1016/j.atherosclerosis.2013.03.022 |
long_lat |
ENVELOPE(-52.150,-52.150,68.717,68.717) |
geographic |
Arctic Greenland Nuuk |
geographic_facet |
Arctic Greenland Nuuk |
genre |
Arctic East Greenland Greenland inuit inuits Nuuk |
genre_facet |
Arctic East Greenland Greenland inuit inuits Nuuk |
op_source |
Schæbel , L H , Vestergaard , H , Laurberg , P M , Rathcke , C N & Andersen , S 2013 , ' Intake of traditional Inuit diet vary in parallel with inflammation as estimated from YKL-40 and hsCRP in Inuit and non-Inuit in Greenland ' , Atherosclerosis , vol. 228 , no. 2 , pp. 496-501 . https://doi.org/10.1016/j.atherosclerosis.2013.03.022 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.atherosclerosis.2013.03.022 |
container_title |
Atherosclerosis |
container_volume |
228 |
container_issue |
2 |
container_start_page |
496 |
op_container_end_page |
501 |
_version_ |
1792045300472348672 |