The genetic structure of Norway
The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with dis...
Published in: | European Journal of Human Genetics |
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Main Authors: | , , , , , , , , , , , |
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Language: | English |
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2021
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Online Access: | https://curis.ku.dk/portal/da/publications/the-genetic-structure-of-norway(f0aa6358-24eb-4153-a8cf-d5d86fb13cc2).html https://doi.org/10.1038/s41431-021-00899-6 https://curis.ku.dk/ws/files/288655654/s41431_021_00899_6.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/f0aa6358-24eb-4153-a8cf-d5d86fb13cc2 2024-06-09T07:49:23+00:00 The genetic structure of Norway Mattingsdal, Morten Ebenesersdóttir, S. Sunna Moore, Kristjan H.S. Andreassen, Ole A. Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Eivind 2021 application/pdf https://curis.ku.dk/portal/da/publications/the-genetic-structure-of-norway(f0aa6358-24eb-4153-a8cf-d5d86fb13cc2).html https://doi.org/10.1038/s41431-021-00899-6 https://curis.ku.dk/ws/files/288655654/s41431_021_00899_6.pdf eng eng info:eu-repo/semantics/openAccess Mattingsdal , M , Ebenesersdóttir , S S , Moore , K H S , Andreassen , O A , Hansen , T F , Werge , T , Kockum , I , Olsson , T , Alfredsson , L , Helgason , A , Stefánsson , K & Hovig , E 2021 , ' The genetic structure of Norway ' , European Journal of Human Genetics , vol. 29 , pp. 1710–1718 . https://doi.org/10.1038/s41431-021-00899-6 article 2021 ftcopenhagenunip https://doi.org/10.1038/s41431-021-00899-6 2024-05-16T11:29:20Z The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway’s long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway. Article in Journal/Newspaper sami University of Copenhagen: Research Norway European Journal of Human Genetics 29 11 1710 1718 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway’s long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway. |
format |
Article in Journal/Newspaper |
author |
Mattingsdal, Morten Ebenesersdóttir, S. Sunna Moore, Kristjan H.S. Andreassen, Ole A. Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Eivind |
spellingShingle |
Mattingsdal, Morten Ebenesersdóttir, S. Sunna Moore, Kristjan H.S. Andreassen, Ole A. Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Eivind The genetic structure of Norway |
author_facet |
Mattingsdal, Morten Ebenesersdóttir, S. Sunna Moore, Kristjan H.S. Andreassen, Ole A. Hansen, Thomas F. Werge, Thomas Kockum, Ingrid Olsson, Tomas Alfredsson, Lars Helgason, Agnar Stefánsson, Kári Hovig, Eivind |
author_sort |
Mattingsdal, Morten |
title |
The genetic structure of Norway |
title_short |
The genetic structure of Norway |
title_full |
The genetic structure of Norway |
title_fullStr |
The genetic structure of Norway |
title_full_unstemmed |
The genetic structure of Norway |
title_sort |
genetic structure of norway |
publishDate |
2021 |
url |
https://curis.ku.dk/portal/da/publications/the-genetic-structure-of-norway(f0aa6358-24eb-4153-a8cf-d5d86fb13cc2).html https://doi.org/10.1038/s41431-021-00899-6 https://curis.ku.dk/ws/files/288655654/s41431_021_00899_6.pdf |
geographic |
Norway |
geographic_facet |
Norway |
genre |
sami |
genre_facet |
sami |
op_source |
Mattingsdal , M , Ebenesersdóttir , S S , Moore , K H S , Andreassen , O A , Hansen , T F , Werge , T , Kockum , I , Olsson , T , Alfredsson , L , Helgason , A , Stefánsson , K & Hovig , E 2021 , ' The genetic structure of Norway ' , European Journal of Human Genetics , vol. 29 , pp. 1710–1718 . https://doi.org/10.1038/s41431-021-00899-6 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41431-021-00899-6 |
container_title |
European Journal of Human Genetics |
container_volume |
29 |
container_issue |
11 |
container_start_page |
1710 |
op_container_end_page |
1718 |
_version_ |
1801381878266068992 |