QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis )
Background: Greenland sled dogs (GSD) are a unique, genetically isolated population of dogs living under exceptional environmental conditions. Metabolism, and thereby thyroid hormones are affected by multiple factors. Among other activity, energy balance and environmental conditions are important. A...
Published in: | Acta Veterinaria Scandinavica |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2021
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Online Access: | https://curis.ku.dk/portal/da/publications/qimmeqhealththyroid-status-of-greenland-sled-dogs-canis-lupus-familiaris-borealis(e8e91a71-0916-4c32-ae2d-70a22b44d029).html https://doi.org/10.1186/s13028-021-00617-8 https://curis.ku.dk/ws/files/286632885/s13028_021_00617_8.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/e8e91a71-0916-4c32-ae2d-70a22b44d029 2024-06-09T07:45:19+00:00 QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) Gjaldbæk, Bolette Winnerskjold Andersen-Ranberg, Emilie Ulrikka Langebæk, Rikke Krogh, Anne Kirstine Havnsøe 2021 application/pdf https://curis.ku.dk/portal/da/publications/qimmeqhealththyroid-status-of-greenland-sled-dogs-canis-lupus-familiaris-borealis(e8e91a71-0916-4c32-ae2d-70a22b44d029).html https://doi.org/10.1186/s13028-021-00617-8 https://curis.ku.dk/ws/files/286632885/s13028_021_00617_8.pdf eng eng info:eu-repo/semantics/openAccess Gjaldbæk , B W , Andersen-Ranberg , E U , Langebæk , R & Krogh , A K H 2021 , ' QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) ' , Acta Veterinaria Scandinavica , vol. 63 , 51 . https://doi.org/10.1186/s13028-021-00617-8 Body condition score Management Reference interval Season Sled dogs Thyroid hormones article 2021 ftcopenhagenunip https://doi.org/10.1186/s13028-021-00617-8 2024-05-16T11:29:22Z Background: Greenland sled dogs (GSD) are a unique, genetically isolated population of dogs living under exceptional environmental conditions. Metabolism, and thereby thyroid hormones are affected by multiple factors. Among other activity, energy balance and environmental conditions are important. A breed-specific reference interval (RI) can be useful for diagnostics of potential thyroid-related pathologies. The aim of this study was to establish RIs of the thyroid hormones thyroxin (T4), free thyroxin (fT4), and thyroid stimulating hormone (TSH) in GSD. In addition to evaluate the effect of sex, age, season, management, and body condition score (BCS) in GSD. Physical exams and cephalic venous blood sampling were performed in the period of 2018–2019 from 265 GSD managed either privately or by the Danish navy. Serum biochemical analyses, including C-reactive protein, were performed and RIs were determined for TSH, T4 and fT4 in only healthy dogs. The RIs were determined using American Society for Veterinary Clinical Pathology guidelines and the effect of varying factors were evaluated by linear regression and further tested by Mann–Whitney test. Results: 144 GSD were included in the reference group resulting in RIs: T4: 6.44–48.65 nmol/L; fT4: 3.91–18.51 pmol/L; and TSH: 0.04–0.55 ng/mL. Female GSD had significantly higher concentrations of T4 (P = 0.039) and fT4 (P = 0.015) compared to males; a positive correlation between TSH and aging was found; T4 concentrations were significantly higher (P = 0.003) during summer; and TSH concentrations were lower in GSD managed by the navy (P < 0.0001). BCS was higher (P < 0.0001) in Sirius GSD compared to civilian GSD, and BCS was positively correlated with T4 and negatively correlated with TSH. Conclusions: Reference intervals for T4, fT4 and TSH in GSD were established. The RI for T4 and fT4 was lower compared to other breeds. In addition, sex, age, season, management and BCS demonstrated variable effects on thyroid hormones. Our results can be used as a foundation ... Article in Journal/Newspaper Canis lupus Greenland University of Copenhagen: Research Greenland Sirius ENVELOPE(163.250,163.250,-84.133,-84.133) Acta Veterinaria Scandinavica 63 1 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Body condition score Management Reference interval Season Sled dogs Thyroid hormones |
spellingShingle |
Body condition score Management Reference interval Season Sled dogs Thyroid hormones Gjaldbæk, Bolette Winnerskjold Andersen-Ranberg, Emilie Ulrikka Langebæk, Rikke Krogh, Anne Kirstine Havnsøe QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) |
topic_facet |
Body condition score Management Reference interval Season Sled dogs Thyroid hormones |
description |
Background: Greenland sled dogs (GSD) are a unique, genetically isolated population of dogs living under exceptional environmental conditions. Metabolism, and thereby thyroid hormones are affected by multiple factors. Among other activity, energy balance and environmental conditions are important. A breed-specific reference interval (RI) can be useful for diagnostics of potential thyroid-related pathologies. The aim of this study was to establish RIs of the thyroid hormones thyroxin (T4), free thyroxin (fT4), and thyroid stimulating hormone (TSH) in GSD. In addition to evaluate the effect of sex, age, season, management, and body condition score (BCS) in GSD. Physical exams and cephalic venous blood sampling were performed in the period of 2018–2019 from 265 GSD managed either privately or by the Danish navy. Serum biochemical analyses, including C-reactive protein, were performed and RIs were determined for TSH, T4 and fT4 in only healthy dogs. The RIs were determined using American Society for Veterinary Clinical Pathology guidelines and the effect of varying factors were evaluated by linear regression and further tested by Mann–Whitney test. Results: 144 GSD were included in the reference group resulting in RIs: T4: 6.44–48.65 nmol/L; fT4: 3.91–18.51 pmol/L; and TSH: 0.04–0.55 ng/mL. Female GSD had significantly higher concentrations of T4 (P = 0.039) and fT4 (P = 0.015) compared to males; a positive correlation between TSH and aging was found; T4 concentrations were significantly higher (P = 0.003) during summer; and TSH concentrations were lower in GSD managed by the navy (P < 0.0001). BCS was higher (P < 0.0001) in Sirius GSD compared to civilian GSD, and BCS was positively correlated with T4 and negatively correlated with TSH. Conclusions: Reference intervals for T4, fT4 and TSH in GSD were established. The RI for T4 and fT4 was lower compared to other breeds. In addition, sex, age, season, management and BCS demonstrated variable effects on thyroid hormones. Our results can be used as a foundation ... |
format |
Article in Journal/Newspaper |
author |
Gjaldbæk, Bolette Winnerskjold Andersen-Ranberg, Emilie Ulrikka Langebæk, Rikke Krogh, Anne Kirstine Havnsøe |
author_facet |
Gjaldbæk, Bolette Winnerskjold Andersen-Ranberg, Emilie Ulrikka Langebæk, Rikke Krogh, Anne Kirstine Havnsøe |
author_sort |
Gjaldbæk, Bolette Winnerskjold |
title |
QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) |
title_short |
QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) |
title_full |
QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) |
title_fullStr |
QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) |
title_full_unstemmed |
QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) |
title_sort |
qimmeqhealth—thyroid status of greenland sled dogs ( canis lupus familiaris borealis ) |
publishDate |
2021 |
url |
https://curis.ku.dk/portal/da/publications/qimmeqhealththyroid-status-of-greenland-sled-dogs-canis-lupus-familiaris-borealis(e8e91a71-0916-4c32-ae2d-70a22b44d029).html https://doi.org/10.1186/s13028-021-00617-8 https://curis.ku.dk/ws/files/286632885/s13028_021_00617_8.pdf |
long_lat |
ENVELOPE(163.250,163.250,-84.133,-84.133) |
geographic |
Greenland Sirius |
geographic_facet |
Greenland Sirius |
genre |
Canis lupus Greenland |
genre_facet |
Canis lupus Greenland |
op_source |
Gjaldbæk , B W , Andersen-Ranberg , E U , Langebæk , R & Krogh , A K H 2021 , ' QimmeqHealth—thyroid status of Greenland sled dogs ( Canis lupus familiaris borealis ) ' , Acta Veterinaria Scandinavica , vol. 63 , 51 . https://doi.org/10.1186/s13028-021-00617-8 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s13028-021-00617-8 |
container_title |
Acta Veterinaria Scandinavica |
container_volume |
63 |
container_issue |
1 |
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1801374611376439296 |