Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population
The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic...
Published in: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
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Online Access: | https://curis.ku.dk/portal/da/publications/wholeexome-sequencing-implicates-dgkh-as-a-risk-gene-for-panic-disorder-in-the-faroese-population(e83a0746-848a-42e1-bd7a-8e2b070fe9f4).html https://doi.org/10.1002/ajmg.b.32464 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/e83a0746-848a-42e1-bd7a-8e2b070fe9f4 2024-05-19T07:40:02+00:00 Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population Gregersen, Noomi Lescai, Francesco Liang, Jieqin Li, Qibin Als, Thomas Buttenschøn, Henriette N Hedemand, Anne Biskopstø, Marjun Wang, Jun Wang, August G Børglum, Anders D Mors, Ole Demontis, Ditte 2016-12 https://curis.ku.dk/portal/da/publications/wholeexome-sequencing-implicates-dgkh-as-a-risk-gene-for-panic-disorder-in-the-faroese-population(e83a0746-848a-42e1-bd7a-8e2b070fe9f4).html https://doi.org/10.1002/ajmg.b.32464 eng eng info:eu-repo/semantics/closedAccess Gregersen , N , Lescai , F , Liang , J , Li , Q , Als , T , Buttenschøn , H N , Hedemand , A , Biskopstø , M , Wang , J , Wang , A G , Børglum , A D , Mors , O & Demontis , D 2016 , ' Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population ' , American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , vol. 171 , no. 8 , pp. 1013-1022 . https://doi.org/10.1002/ajmg.b.32464 article 2016 ftcopenhagenunip https://doi.org/10.1002/ajmg.b.32464 2024-04-25T00:45:03Z The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population. No genome-wide significant associations were found, however several single variants and genes showed strong association with PD, where DGKH was found to be the strongest PD associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. Additionally, we found an enrichment of PD risk variants in the Faroese population; variants with otherwise low frequency in more outbreed European populations. © 2016 Wiley Periodicals, Inc. Article in Journal/Newspaper Faroe Islands University of Copenhagen: Research American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171 8 1013 1022 |
institution |
Open Polar |
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University of Copenhagen: Research |
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ftcopenhagenunip |
language |
English |
description |
The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population. No genome-wide significant associations were found, however several single variants and genes showed strong association with PD, where DGKH was found to be the strongest PD associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. Additionally, we found an enrichment of PD risk variants in the Faroese population; variants with otherwise low frequency in more outbreed European populations. © 2016 Wiley Periodicals, Inc. |
format |
Article in Journal/Newspaper |
author |
Gregersen, Noomi Lescai, Francesco Liang, Jieqin Li, Qibin Als, Thomas Buttenschøn, Henriette N Hedemand, Anne Biskopstø, Marjun Wang, Jun Wang, August G Børglum, Anders D Mors, Ole Demontis, Ditte |
spellingShingle |
Gregersen, Noomi Lescai, Francesco Liang, Jieqin Li, Qibin Als, Thomas Buttenschøn, Henriette N Hedemand, Anne Biskopstø, Marjun Wang, Jun Wang, August G Børglum, Anders D Mors, Ole Demontis, Ditte Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population |
author_facet |
Gregersen, Noomi Lescai, Francesco Liang, Jieqin Li, Qibin Als, Thomas Buttenschøn, Henriette N Hedemand, Anne Biskopstø, Marjun Wang, Jun Wang, August G Børglum, Anders D Mors, Ole Demontis, Ditte |
author_sort |
Gregersen, Noomi |
title |
Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population |
title_short |
Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population |
title_full |
Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population |
title_fullStr |
Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population |
title_full_unstemmed |
Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population |
title_sort |
whole-exome sequencing implicates dgkh as a risk gene for panic disorder in the faroese population |
publishDate |
2016 |
url |
https://curis.ku.dk/portal/da/publications/wholeexome-sequencing-implicates-dgkh-as-a-risk-gene-for-panic-disorder-in-the-faroese-population(e83a0746-848a-42e1-bd7a-8e2b070fe9f4).html https://doi.org/10.1002/ajmg.b.32464 |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Gregersen , N , Lescai , F , Liang , J , Li , Q , Als , T , Buttenschøn , H N , Hedemand , A , Biskopstø , M , Wang , J , Wang , A G , Børglum , A D , Mors , O & Demontis , D 2016 , ' Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population ' , American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , vol. 171 , no. 8 , pp. 1013-1022 . https://doi.org/10.1002/ajmg.b.32464 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1002/ajmg.b.32464 |
container_title |
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
container_volume |
171 |
container_issue |
8 |
container_start_page |
1013 |
op_container_end_page |
1022 |
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1799479616410222592 |