Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome
Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental...
Published in: | Environmental Science & Technology |
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2022
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Online Access: | https://curis.ku.dk/portal/da/publications/effects-of-lifetime-exposures-to-environmental-contaminants-on-the-adult-gut-microbiome(cf2facf9-e8b1-457e-943b-60607ab16afb).html https://doi.org/10.1021/acs.est.2c03185 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/cf2facf9-e8b1-457e-943b-60607ab16afb 2024-06-09T07:45:51+00:00 Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe 2022 https://curis.ku.dk/portal/da/publications/effects-of-lifetime-exposures-to-environmental-contaminants-on-the-adult-gut-microbiome(cf2facf9-e8b1-457e-943b-60607ab16afb).html https://doi.org/10.1021/acs.est.2c03185 eng eng info:eu-repo/semantics/closedAccess Thompson , K N , Oulhote , Y , Weihe , P , Wilkinson , J E , Ma , S , Zhong , H , Li , J , Kristiansen , K , Huttenhower , C & Grandjean , P 2022 , ' Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome ' , Environmental Science & Technology , vol. 56 , no. 23 , pp. 16985-16995 . https://doi.org/10.1021/acs.est.2c03185 gut microbiome early life exposure NEUROBEHAVIORAL DEFICITS METHYLMERCURIC CHLORIDE MERCURY METABOLISM HEALTH CHAIN article 2022 ftcopenhagenunip https://doi.org/10.1021/acs.est.2c03185 2024-05-16T11:29:26Z Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986–1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants’ blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome. Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances ... Article in Journal/Newspaper Faroe Islands University of Copenhagen: Research Faroe Islands Environmental Science & Technology 56 23 16985 16995 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
gut microbiome early life exposure NEUROBEHAVIORAL DEFICITS METHYLMERCURIC CHLORIDE MERCURY METABOLISM HEALTH CHAIN |
spellingShingle |
gut microbiome early life exposure NEUROBEHAVIORAL DEFICITS METHYLMERCURIC CHLORIDE MERCURY METABOLISM HEALTH CHAIN Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
topic_facet |
gut microbiome early life exposure NEUROBEHAVIORAL DEFICITS METHYLMERCURIC CHLORIDE MERCURY METABOLISM HEALTH CHAIN |
description |
Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986–1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances (PFAS), and mercury (Hg), were measured in cord blood and longitudinally in participants’ blood. At age 28, the gut microbiome was assessed using shotgun metagenomic sequencing. Historical contaminant exposures had little direct effect on the adult gut microbiome, while a small number of fastidious anaerobes were weakly linked to recent PFAS/PFOS exposures at age 28. In this cohort, our findings suggest no lasting effects of early life exposures on adult gut microbial composition, but proximal exposures may contribute to gut microbiome alterations. The methods developed and used for this investigation may help in future identification of small but lasting impacts of environmental toxicant exposure on the gut microbiome. Emerging experimental evidence indicates that toxicant-induced alterations in gut microbiota composition and activity may affect host homeostasis. However, data from human studies are scarce; to our knowledge, no previous studies have quantified the association of lifetime exposure to environmental chemicals, across multiple time points, with the composition of the adult gut microbiome. Here we studied 124 individuals born in the Faroe Islands in 1986-1987 who were followed approximately every seven years from birth through age 28 years. Organochlorine compounds, including polychlorinated biphenyls (PCBs) and pesticides, perfluoroalkyl substances ... |
format |
Article in Journal/Newspaper |
author |
Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe |
author_facet |
Thompson, Kelsey N. Oulhote, Youssef Weihe, Pal Wilkinson, Jeremy E. Ma, Siyuan Zhong, Huanzi Li, Junhua Kristiansen, Karsten Huttenhower, Curtis Grandjean, Philippe |
author_sort |
Thompson, Kelsey N. |
title |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_short |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_full |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_fullStr |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_full_unstemmed |
Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome |
title_sort |
effects of lifetime exposures to environmental contaminants on the adult gut microbiome |
publishDate |
2022 |
url |
https://curis.ku.dk/portal/da/publications/effects-of-lifetime-exposures-to-environmental-contaminants-on-the-adult-gut-microbiome(cf2facf9-e8b1-457e-943b-60607ab16afb).html https://doi.org/10.1021/acs.est.2c03185 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Thompson , K N , Oulhote , Y , Weihe , P , Wilkinson , J E , Ma , S , Zhong , H , Li , J , Kristiansen , K , Huttenhower , C & Grandjean , P 2022 , ' Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome ' , Environmental Science & Technology , vol. 56 , no. 23 , pp. 16985-16995 . https://doi.org/10.1021/acs.est.2c03185 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1021/acs.est.2c03185 |
container_title |
Environmental Science & Technology |
container_volume |
56 |
container_issue |
23 |
container_start_page |
16985 |
op_container_end_page |
16995 |
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1801375495113146368 |