Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos)
Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for...
Published in: | Frontiers in Veterinary Science |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2019
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Online Access: | https://curis.ku.dk/portal/da/publications/assessment-of-the-leadcare-plus-for-use-on-scandinavian-brown-bears-ursus-arctos(cbd3220c-7b93-45e7-a583-d491702ef6d5).html https://doi.org/10.3389/fvets.2019.00285 https://curis.ku.dk/ws/files/282533367/fvets_06_00285.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/cbd3220c-7b93-45e7-a583-d491702ef6d5 2024-05-19T07:49:45+00:00 Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. 2019 application/pdf https://curis.ku.dk/portal/da/publications/assessment-of-the-leadcare-plus-for-use-on-scandinavian-brown-bears-ursus-arctos(cbd3220c-7b93-45e7-a583-d491702ef6d5).html https://doi.org/10.3389/fvets.2019.00285 https://curis.ku.dk/ws/files/282533367/fvets_06_00285.pdf eng eng info:eu-repo/semantics/openAccess Boesen , A H , Thiel , A , Fuchs , B , Evans , A L , Bertelsen , M F , Rodushkin , I & Arnemo , J M 2019 , ' Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) ' , Frontiers in Veterinary Science , vol. 6 , no. AUG , 285 . https://doi.org/10.3389/fvets.2019.00285 Anodic stripping voltammetry Blood lead Lead exposure Pb Ursus article 2019 ftcopenhagenunip https://doi.org/10.3389/fvets.2019.00285 2024-04-25T00:45:07Z Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for use in some avian species and cattle, and are increasingly being used on wildlife to monitor lead exposure. The LeadCare® analyzers use a technique called anodic stripping voltammetry (ASV). Species-specific conversion equations have been proposed to approximate the levels found with gold standard measuring methods such as inductively coupled plasma mass spectrometry (ICP-MS) because the ASV method has been shown to underestimate BLL in some species. In this study we assessed the LeadCare® Plus (LCP) for use on Scandinavian brown bears (Ursus arctos). LCP measurements were correlated with ICP-MS with a Bland-Altman analyzed bias of 16.3–22.5%, showing a consistent overestimation of BLL analyzed with LCP. Based on this analysis we provide conversion equations for calculating ICP-MS BLL based on the LCP results in Scandinavian brown bears. Our study shows that the LeadCare® Plus can be used for monitoring of lead exposure by approximating gold standard levels using conversion equations. This enables comparison with other gold standard measured BLL within the observed range of this study (38.20–174.00 μg/L). Our study also found that Scandinavian brown bears are highly exposed to environmental lead. Article in Journal/Newspaper Ursus arctos University of Copenhagen: Research Frontiers in Veterinary Science 6 |
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Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Anodic stripping voltammetry Blood lead Lead exposure Pb Ursus |
spellingShingle |
Anodic stripping voltammetry Blood lead Lead exposure Pb Ursus Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) |
topic_facet |
Anodic stripping voltammetry Blood lead Lead exposure Pb Ursus |
description |
Lead (Pb) exposure is associated with adverse health effects in both humans and wildlife. Blood lead levels (BLL) of sentinel wildlife species can be used to monitor environmental lead exposure and ecosystem health. BLL analyzers, such as the LeadCare®, are validated for use in humans, assessed for use in some avian species and cattle, and are increasingly being used on wildlife to monitor lead exposure. The LeadCare® analyzers use a technique called anodic stripping voltammetry (ASV). Species-specific conversion equations have been proposed to approximate the levels found with gold standard measuring methods such as inductively coupled plasma mass spectrometry (ICP-MS) because the ASV method has been shown to underestimate BLL in some species. In this study we assessed the LeadCare® Plus (LCP) for use on Scandinavian brown bears (Ursus arctos). LCP measurements were correlated with ICP-MS with a Bland-Altman analyzed bias of 16.3–22.5%, showing a consistent overestimation of BLL analyzed with LCP. Based on this analysis we provide conversion equations for calculating ICP-MS BLL based on the LCP results in Scandinavian brown bears. Our study shows that the LeadCare® Plus can be used for monitoring of lead exposure by approximating gold standard levels using conversion equations. This enables comparison with other gold standard measured BLL within the observed range of this study (38.20–174.00 μg/L). Our study also found that Scandinavian brown bears are highly exposed to environmental lead. |
format |
Article in Journal/Newspaper |
author |
Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. |
author_facet |
Boesen, Amanda H. Thiel, Alexandra Fuchs, Boris Evans, Alina L. Bertelsen, Mads F. Rodushkin, Ilia Arnemo, Jon M. |
author_sort |
Boesen, Amanda H. |
title |
Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) |
title_short |
Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) |
title_full |
Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) |
title_fullStr |
Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) |
title_full_unstemmed |
Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) |
title_sort |
assessment of the leadcare® plus for use on scandinavian brown bears (ursus arctos) |
publishDate |
2019 |
url |
https://curis.ku.dk/portal/da/publications/assessment-of-the-leadcare-plus-for-use-on-scandinavian-brown-bears-ursus-arctos(cbd3220c-7b93-45e7-a583-d491702ef6d5).html https://doi.org/10.3389/fvets.2019.00285 https://curis.ku.dk/ws/files/282533367/fvets_06_00285.pdf |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Boesen , A H , Thiel , A , Fuchs , B , Evans , A L , Bertelsen , M F , Rodushkin , I & Arnemo , J M 2019 , ' Assessment of the LeadCare® plus for use on Scandinavian brown bears (Ursus arctos) ' , Frontiers in Veterinary Science , vol. 6 , no. AUG , 285 . https://doi.org/10.3389/fvets.2019.00285 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3389/fvets.2019.00285 |
container_title |
Frontiers in Veterinary Science |
container_volume |
6 |
_version_ |
1799468304250699776 |