The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers...
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2020
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Online Access: | https://curis.ku.dk/portal/da/publications/the-effect-of-diabetes-and-the-common-diabetogenic-tbc1d4-parg684ter-variant-on-cardiovascular-risk-in-inuit-in-greenland(ca4aa9b7-fef7-43e6-83a8-da4c557c0949).html https://doi.org/10.1038/s41598-020-79132-1 https://curis.ku.dk/ws/files/255355126/The_effect_of_diabetes_and_the_common_diabetogenic_TBC1D4_p.Arg684Ter_variant_on_cardiovascular_risk_in_Inuit_in_Greenland.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/ca4aa9b7-fef7-43e6-83a8-da4c557c0949 2024-05-19T07:41:01+00:00 The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika 2020 application/pdf https://curis.ku.dk/portal/da/publications/the-effect-of-diabetes-and-the-common-diabetogenic-tbc1d4-parg684ter-variant-on-cardiovascular-risk-in-inuit-in-greenland(ca4aa9b7-fef7-43e6-83a8-da4c557c0949).html https://doi.org/10.1038/s41598-020-79132-1 https://curis.ku.dk/ws/files/255355126/The_effect_of_diabetes_and_the_common_diabetogenic_TBC1D4_p.Arg684Ter_variant_on_cardiovascular_risk_in_Inuit_in_Greenland.pdf eng eng info:eu-repo/semantics/openAccess Overvad , M , Diaz , L J , Bjerregaard , P , Pedersen , M L , Larsen , C V L , Senftleber , N , Grarup , N , Hansen , T & Jørgensen , M E 2020 , ' The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland ' , Scientific Reports , vol. 10 , 22081 . https://doi.org/10.1038/s41598-020-79132-1 article 2020 ftcopenhagenunip https://doi.org/10.1038/s41598-020-79132-1 2024-05-02T00:33:11Z Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models. Article in Journal/Newspaper Greenland inuit University of Copenhagen: Research Scientific Reports 10 1 |
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Open Polar |
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University of Copenhagen: Research |
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ftcopenhagenunip |
language |
English |
description |
Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models. |
format |
Article in Journal/Newspaper |
author |
Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika |
spellingShingle |
Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
author_facet |
Overvad, Maria Diaz, Lars Jorge Bjerregaard, Peter Pedersen, Michael Lynge Larsen, Christina Viskum Lytken Senftleber, Ninna Grarup, Niels Hansen, Torben Jørgensen, Marit Eika |
author_sort |
Overvad, Maria |
title |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_short |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_full |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_fullStr |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_full_unstemmed |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_sort |
effect of diabetes and the common diabetogenic tbc1d4 p.arg684ter variant on cardiovascular risk in inuit in greenland |
publishDate |
2020 |
url |
https://curis.ku.dk/portal/da/publications/the-effect-of-diabetes-and-the-common-diabetogenic-tbc1d4-parg684ter-variant-on-cardiovascular-risk-in-inuit-in-greenland(ca4aa9b7-fef7-43e6-83a8-da4c557c0949).html https://doi.org/10.1038/s41598-020-79132-1 https://curis.ku.dk/ws/files/255355126/The_effect_of_diabetes_and_the_common_diabetogenic_TBC1D4_p.Arg684Ter_variant_on_cardiovascular_risk_in_Inuit_in_Greenland.pdf |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
Overvad , M , Diaz , L J , Bjerregaard , P , Pedersen , M L , Larsen , C V L , Senftleber , N , Grarup , N , Hansen , T & Jørgensen , M E 2020 , ' The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland ' , Scientific Reports , vol. 10 , 22081 . https://doi.org/10.1038/s41598-020-79132-1 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41598-020-79132-1 |
container_title |
Scientific Reports |
container_volume |
10 |
container_issue |
1 |
_version_ |
1799480592121724928 |