Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study
Undifferentiated nasopharyngeal carcinoma is a result of environmental factors, in particular EBV infection, affecting genetically susceptible individuals. The familial risk of nasopharyngeal carcinoma is among the highest of any malignancy. Whether this susceptibility is restricted to nasopharyngea...
Published in: | Cancer Research |
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2005
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Online Access: | https://curis.ku.dk/portal/da/publications/cancer-susceptibility-in-nasopharyngeal-carcinoma-families--a-populationbased-cohort-study(c686ef32-959f-4f68-8177-3e4c53f9d53e).html https://doi.org/10.1158/0008-5472.CAN-04-4208 http://www.scopus.com/inward/record.url?scp=24944552905&partnerID=8YFLogxK |
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ftcopenhagenunip:oai:pure.atira.dk:publications/c686ef32-959f-4f68-8177-3e4c53f9d53e 2023-12-03T10:23:28+01:00 Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study Friborg, Jeppe Wohlfahrt, Jan Koch, Anders Storm, Hans Olsen, Ove R. Melbye, Mads 2005-09-15 https://curis.ku.dk/portal/da/publications/cancer-susceptibility-in-nasopharyngeal-carcinoma-families--a-populationbased-cohort-study(c686ef32-959f-4f68-8177-3e4c53f9d53e).html https://doi.org/10.1158/0008-5472.CAN-04-4208 http://www.scopus.com/inward/record.url?scp=24944552905&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Friborg , J , Wohlfahrt , J , Koch , A , Storm , H , Olsen , O R & Melbye , M 2005 , ' Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study ' , Cancer Research , vol. 65 , no. 18 , pp. 8567-8572 . https://doi.org/10.1158/0008-5472.CAN-04-4208 article 2005 ftcopenhagenunip https://doi.org/10.1158/0008-5472.CAN-04-4208 2023-11-09T00:07:52Z Undifferentiated nasopharyngeal carcinoma is a result of environmental factors, in particular EBV infection, affecting genetically susceptible individuals. The familial risk of nasopharyngeal carcinoma is among the highest of any malignancy. Whether this susceptibility is restricted to nasopharyngeal carcinoma is unknown as information on the risk of other cancers in relatives is limited. We did a population-based study of the cancer incidence in nasopharyngeal carcinoma families in Greenland, a nasopharyngeal carcinoma-endemic area. Using population-based registers, a cohort of all persons born in Greenland was followed from 1973 to 2002. In this cohort, 134 individuals developed nasopharyngeal carcinoma and their relatives were identified through registers and interviews. Subsequently, the occurrence of cancer was determined by linkage to the population-based cancer register and the risk of cancer in nasopharyngeal carcinoma relatives and nonrelatives compared by relative risks. Among 766 first-degree relatives, the relative risk of nasopharyngeal carcinoma following the family index case was 8.0 [95% confidence interval (95% CI), 4.1-14.0]. Sex and age of the relative or the index case had no modifying effect on the familial risk of nasopharyngeal carcinoma. The relative risks of carcinoma of the salivary glands, 8.4 (95% CI, 2.7-19.5), and uterine cervix, 2.2 (95% CI, 1.1-3.9), were also significantly increased. In families with multiple cases of nasopharyngeal carcinoma, the risk of other cancers than nasopharyngeal carcinoma was further increased. These results indicate that the increased risk of cancer in nasopharyngeal carcinoma families is not restricted to nasopharyngeal carcinoma, but extends to the virally associated cancers of the salivary glands and cervical uteri. Article in Journal/Newspaper Greenland University of Copenhagen: Research Greenland Cancer Research 65 18 8567 8572 |
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University of Copenhagen: Research |
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ftcopenhagenunip |
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English |
description |
Undifferentiated nasopharyngeal carcinoma is a result of environmental factors, in particular EBV infection, affecting genetically susceptible individuals. The familial risk of nasopharyngeal carcinoma is among the highest of any malignancy. Whether this susceptibility is restricted to nasopharyngeal carcinoma is unknown as information on the risk of other cancers in relatives is limited. We did a population-based study of the cancer incidence in nasopharyngeal carcinoma families in Greenland, a nasopharyngeal carcinoma-endemic area. Using population-based registers, a cohort of all persons born in Greenland was followed from 1973 to 2002. In this cohort, 134 individuals developed nasopharyngeal carcinoma and their relatives were identified through registers and interviews. Subsequently, the occurrence of cancer was determined by linkage to the population-based cancer register and the risk of cancer in nasopharyngeal carcinoma relatives and nonrelatives compared by relative risks. Among 766 first-degree relatives, the relative risk of nasopharyngeal carcinoma following the family index case was 8.0 [95% confidence interval (95% CI), 4.1-14.0]. Sex and age of the relative or the index case had no modifying effect on the familial risk of nasopharyngeal carcinoma. The relative risks of carcinoma of the salivary glands, 8.4 (95% CI, 2.7-19.5), and uterine cervix, 2.2 (95% CI, 1.1-3.9), were also significantly increased. In families with multiple cases of nasopharyngeal carcinoma, the risk of other cancers than nasopharyngeal carcinoma was further increased. These results indicate that the increased risk of cancer in nasopharyngeal carcinoma families is not restricted to nasopharyngeal carcinoma, but extends to the virally associated cancers of the salivary glands and cervical uteri. |
format |
Article in Journal/Newspaper |
author |
Friborg, Jeppe Wohlfahrt, Jan Koch, Anders Storm, Hans Olsen, Ove R. Melbye, Mads |
spellingShingle |
Friborg, Jeppe Wohlfahrt, Jan Koch, Anders Storm, Hans Olsen, Ove R. Melbye, Mads Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study |
author_facet |
Friborg, Jeppe Wohlfahrt, Jan Koch, Anders Storm, Hans Olsen, Ove R. Melbye, Mads |
author_sort |
Friborg, Jeppe |
title |
Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study |
title_short |
Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study |
title_full |
Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study |
title_fullStr |
Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study |
title_full_unstemmed |
Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study |
title_sort |
cancer susceptibility in nasopharyngeal carcinoma families - a population-based cohort study |
publishDate |
2005 |
url |
https://curis.ku.dk/portal/da/publications/cancer-susceptibility-in-nasopharyngeal-carcinoma-families--a-populationbased-cohort-study(c686ef32-959f-4f68-8177-3e4c53f9d53e).html https://doi.org/10.1158/0008-5472.CAN-04-4208 http://www.scopus.com/inward/record.url?scp=24944552905&partnerID=8YFLogxK |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Friborg , J , Wohlfahrt , J , Koch , A , Storm , H , Olsen , O R & Melbye , M 2005 , ' Cancer susceptibility in nasopharyngeal carcinoma families - A population-based cohort study ' , Cancer Research , vol. 65 , no. 18 , pp. 8567-8572 . https://doi.org/10.1158/0008-5472.CAN-04-4208 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1158/0008-5472.CAN-04-4208 |
container_title |
Cancer Research |
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65 |
container_issue |
18 |
container_start_page |
8567 |
op_container_end_page |
8572 |
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