Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway
A method for the determination of five selective serotonin reuptake inhibitors (citalopram, sertraline, fluoxetine, fluvoxamine and paroxetine) and four of their metabolites (desmethylcitalopram, didesmethylcitalopram, norfluoxetine and desmethylsertraline) in seawater and sewage influents and efflu...
Published in: | Journal of Chromatography A |
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Language: | English |
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2008
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Online Access: | https://curis.ku.dk/portal/da/publications/occurrence-of-selective-serotonin-reuptake-inhibitors-in-sewage-and-receiving-waters-at-spitsbergen-and-in-norway(c5e76ad8-ae2f-4203-a0d6-33d139394be5).html https://doi.org/10.1016/j.chroma.2008.01.063 http://www.scopus.com/inward/record.url?scp=40049090536&partnerID=8YFLogxK |
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ftcopenhagenunip:oai:pure.atira.dk:publications/c5e76ad8-ae2f-4203-a0d6-33d139394be5 2024-05-12T08:06:45+00:00 Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway Vasskog, Terje Anderssen, Trude Pedersen-Bjergaard, Stig Kallenborn, Roland Jensen, Einar 2008-03-28 https://curis.ku.dk/portal/da/publications/occurrence-of-selective-serotonin-reuptake-inhibitors-in-sewage-and-receiving-waters-at-spitsbergen-and-in-norway(c5e76ad8-ae2f-4203-a0d6-33d139394be5).html https://doi.org/10.1016/j.chroma.2008.01.063 http://www.scopus.com/inward/record.url?scp=40049090536&partnerID=8YFLogxK eng eng info:eu-repo/semantics/restrictedAccess Vasskog , T , Anderssen , T , Pedersen-Bjergaard , S , Kallenborn , R & Jensen , E 2008 , ' Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway ' , Journal of Chromatography A , vol. 1185 , no. 2 , pp. 194-205 . https://doi.org/10.1016/j.chroma.2008.01.063 Environment LC-MS/MS LPME Sewage SSRI Trace analysis article 2008 ftcopenhagenunip https://doi.org/10.1016/j.chroma.2008.01.063 2024-04-18T00:28:16Z A method for the determination of five selective serotonin reuptake inhibitors (citalopram, sertraline, fluoxetine, fluvoxamine and paroxetine) and four of their metabolites (desmethylcitalopram, didesmethylcitalopram, norfluoxetine and desmethylsertraline) in seawater and sewage influents and effluents, has been developed and validated. The method is based on a three-phase hollow-fibre supported liquid phase microextraction of 1.1 L samples, followed by high performance liquid chromatography with electrospray ionization and mass spectrometric detection. The detection limits varied between 17 pg/L (citalopram) and 618 ng/L (desmethylsertraline), and the quantification limits between 57 pg/L (citalopram) and 4.1 ng/L (desmethylsertraline). Sampling was done from February to August in 2007 on three different locations with dissimilarities concerning waste water treatment procedures. No significant difference in SSRI cleansing efficiency between merely sieving (Langnes STP, Tromsø) and a more advanced sewage treatment (VEAS STP, Oslo) was seen. All the investigated compounds are present in all waste water samples from these STPs, and a total concentration of SSRIs and metabolites up to 840 ng/L has been found. Untreated sewage samples have been collected in the small town Longyearbyen at Spitsbergen. Despite few inhabitants (2000), it was still possible to find traces of SSRIs in the waste water. In Tromsø and Longyearbyen the waste water is discharged into the sea, therefore seawater samples have been collected close to the outlets. The results show higher concentrations of SSRIs outside Longyearbyen than Tromsø, possibly due to the stronger tidal currents around Tromsø. However, the concentrations are quite low, not exceeding total concentrations of 3 ng/L. Article in Journal/Newspaper Longyearbyen Tromsø Spitsbergen University of Copenhagen: Research Longyearbyen Norway Tromsø Journal of Chromatography A 1185 2 194 205 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Environment LC-MS/MS LPME Sewage SSRI Trace analysis |
spellingShingle |
Environment LC-MS/MS LPME Sewage SSRI Trace analysis Vasskog, Terje Anderssen, Trude Pedersen-Bjergaard, Stig Kallenborn, Roland Jensen, Einar Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway |
topic_facet |
Environment LC-MS/MS LPME Sewage SSRI Trace analysis |
description |
A method for the determination of five selective serotonin reuptake inhibitors (citalopram, sertraline, fluoxetine, fluvoxamine and paroxetine) and four of their metabolites (desmethylcitalopram, didesmethylcitalopram, norfluoxetine and desmethylsertraline) in seawater and sewage influents and effluents, has been developed and validated. The method is based on a three-phase hollow-fibre supported liquid phase microextraction of 1.1 L samples, followed by high performance liquid chromatography with electrospray ionization and mass spectrometric detection. The detection limits varied between 17 pg/L (citalopram) and 618 ng/L (desmethylsertraline), and the quantification limits between 57 pg/L (citalopram) and 4.1 ng/L (desmethylsertraline). Sampling was done from February to August in 2007 on three different locations with dissimilarities concerning waste water treatment procedures. No significant difference in SSRI cleansing efficiency between merely sieving (Langnes STP, Tromsø) and a more advanced sewage treatment (VEAS STP, Oslo) was seen. All the investigated compounds are present in all waste water samples from these STPs, and a total concentration of SSRIs and metabolites up to 840 ng/L has been found. Untreated sewage samples have been collected in the small town Longyearbyen at Spitsbergen. Despite few inhabitants (2000), it was still possible to find traces of SSRIs in the waste water. In Tromsø and Longyearbyen the waste water is discharged into the sea, therefore seawater samples have been collected close to the outlets. The results show higher concentrations of SSRIs outside Longyearbyen than Tromsø, possibly due to the stronger tidal currents around Tromsø. However, the concentrations are quite low, not exceeding total concentrations of 3 ng/L. |
format |
Article in Journal/Newspaper |
author |
Vasskog, Terje Anderssen, Trude Pedersen-Bjergaard, Stig Kallenborn, Roland Jensen, Einar |
author_facet |
Vasskog, Terje Anderssen, Trude Pedersen-Bjergaard, Stig Kallenborn, Roland Jensen, Einar |
author_sort |
Vasskog, Terje |
title |
Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway |
title_short |
Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway |
title_full |
Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway |
title_fullStr |
Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway |
title_full_unstemmed |
Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway |
title_sort |
occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at spitsbergen and in norway |
publishDate |
2008 |
url |
https://curis.ku.dk/portal/da/publications/occurrence-of-selective-serotonin-reuptake-inhibitors-in-sewage-and-receiving-waters-at-spitsbergen-and-in-norway(c5e76ad8-ae2f-4203-a0d6-33d139394be5).html https://doi.org/10.1016/j.chroma.2008.01.063 http://www.scopus.com/inward/record.url?scp=40049090536&partnerID=8YFLogxK |
geographic |
Longyearbyen Norway Tromsø |
geographic_facet |
Longyearbyen Norway Tromsø |
genre |
Longyearbyen Tromsø Spitsbergen |
genre_facet |
Longyearbyen Tromsø Spitsbergen |
op_source |
Vasskog , T , Anderssen , T , Pedersen-Bjergaard , S , Kallenborn , R & Jensen , E 2008 , ' Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway ' , Journal of Chromatography A , vol. 1185 , no. 2 , pp. 194-205 . https://doi.org/10.1016/j.chroma.2008.01.063 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.chroma.2008.01.063 |
container_title |
Journal of Chromatography A |
container_volume |
1185 |
container_issue |
2 |
container_start_page |
194 |
op_container_end_page |
205 |
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1798849289673244672 |