The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study
In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is...
Published in: | International Journal of Circumpolar Health |
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Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2023
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Online Access: | https://curis.ku.dk/portal/da/publications/the-effect-of-sucraseisomaltase-deficiency-on-metabolism-food-intake-and-preferences(c427345c-74aa-49d2-8d4b-7404af6d7b35).html https://doi.org/10.1080/22423982.2023.2178067 https://curis.ku.dk/ws/files/338447367/Fulltext.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/c427345c-74aa-49d2-8d4b-7404af6d7b35 2024-06-09T07:45:26+00:00 The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study Senftleber, Ninna Karsbæk Pedersen, Kristine Skøtt Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika 2023 application/pdf https://curis.ku.dk/portal/da/publications/the-effect-of-sucraseisomaltase-deficiency-on-metabolism-food-intake-and-preferences(c427345c-74aa-49d2-8d4b-7404af6d7b35).html https://doi.org/10.1080/22423982.2023.2178067 https://curis.ku.dk/ws/files/338447367/Fulltext.pdf eng eng info:eu-repo/semantics/openAccess Senftleber , N K , Pedersen , K S , Schnoor Jørgensen , C , Pedersen , H , Bjerg Christensen , M M , Kabel Madsen , E , Andersen , K , Jørsboe , E , Gillum , M P , Frøst , M B , Hansen , T & Jørgensen , M E 2023 , ' The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences : protocol for a dietary intervention study ' , International Journal of Circumpolar Health , vol. 82 , no. 1 , 2178067 . https://doi.org/10.1080/22423982.2023.2178067 Congenital sucrase-isomaltase deficiency dietary intervention food preferences greenland inuit diet metabolism microbiota article 2023 ftcopenhagenunip https://doi.org/10.1080/22423982.2023.2178067 2024-05-16T11:29:28Z In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656. Article in Journal/Newspaper Circumpolar Health Greenland greenlander* greenlandic International Journal of Circumpolar Health inuit University of Copenhagen: Research Greenland International Journal of Circumpolar Health 82 1 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Congenital sucrase-isomaltase deficiency dietary intervention food preferences greenland inuit diet metabolism microbiota |
spellingShingle |
Congenital sucrase-isomaltase deficiency dietary intervention food preferences greenland inuit diet metabolism microbiota Senftleber, Ninna Karsbæk Pedersen, Kristine Skøtt Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study |
topic_facet |
Congenital sucrase-isomaltase deficiency dietary intervention food preferences greenland inuit diet metabolism microbiota |
description |
In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656. |
format |
Article in Journal/Newspaper |
author |
Senftleber, Ninna Karsbæk Pedersen, Kristine Skøtt Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika |
author_facet |
Senftleber, Ninna Karsbæk Pedersen, Kristine Skøtt Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika |
author_sort |
Senftleber, Ninna Karsbæk |
title |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study |
title_short |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study |
title_full |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study |
title_fullStr |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study |
title_full_unstemmed |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study |
title_sort |
effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences:protocol for a dietary intervention study |
publishDate |
2023 |
url |
https://curis.ku.dk/portal/da/publications/the-effect-of-sucraseisomaltase-deficiency-on-metabolism-food-intake-and-preferences(c427345c-74aa-49d2-8d4b-7404af6d7b35).html https://doi.org/10.1080/22423982.2023.2178067 https://curis.ku.dk/ws/files/338447367/Fulltext.pdf |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Circumpolar Health Greenland greenlander* greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Circumpolar Health Greenland greenlander* greenlandic International Journal of Circumpolar Health inuit |
op_source |
Senftleber , N K , Pedersen , K S , Schnoor Jørgensen , C , Pedersen , H , Bjerg Christensen , M M , Kabel Madsen , E , Andersen , K , Jørsboe , E , Gillum , M P , Frøst , M B , Hansen , T & Jørgensen , M E 2023 , ' The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences : protocol for a dietary intervention study ' , International Journal of Circumpolar Health , vol. 82 , no. 1 , 2178067 . https://doi.org/10.1080/22423982.2023.2178067 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2023.2178067 |
container_title |
International Journal of Circumpolar Health |
container_volume |
82 |
container_issue |
1 |
_version_ |
1801374789636456448 |