Effectiveness of the targeted hepatitis B vaccination program in Greenland
Objectives. To evaluate the effectiveness of the hepatitis B virus (HBV) vaccination program in Greenland, which targets children born to mothers who are positive for HBV surface antigen (HBsAg), we determined vaccination coverage, levels of postvaccination antibodies, and frequency of breakthrough...
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2012
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Online Access: | https://curis.ku.dk/portal/da/publications/effectiveness-of-the-targeted-hepatitis-b-vaccination-program-in-greenland(c3212895-e1eb-46b5-8592-a16d735a87ba).html https://doi.org/10.2105/AJPH.2011.300239 http://www.scopus.com/inward/record.url?scp=84857340273&partnerID=8YFLogxK |
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ftcopenhagenunip:oai:pure.atira.dk:publications/c3212895-e1eb-46b5-8592-a16d735a87ba 2023-12-03T10:23:21+01:00 Effectiveness of the targeted hepatitis B vaccination program in Greenland Børresen, Malene L. Koch, Anders Biggar, Robert J. Ladefoged, Karin Melbye, Mads Wohlfahrt, Jan Krause, Tyra Grove 2012-02 https://curis.ku.dk/portal/da/publications/effectiveness-of-the-targeted-hepatitis-b-vaccination-program-in-greenland(c3212895-e1eb-46b5-8592-a16d735a87ba).html https://doi.org/10.2105/AJPH.2011.300239 http://www.scopus.com/inward/record.url?scp=84857340273&partnerID=8YFLogxK eng eng info:eu-repo/semantics/restrictedAccess Børresen , M L , Koch , A , Biggar , R J , Ladefoged , K , Melbye , M , Wohlfahrt , J & Krause , T G 2012 , ' Effectiveness of the targeted hepatitis B vaccination program in Greenland ' , American Journal of Public Health , vol. 102 , no. 2 , pp. 277-284 . https://doi.org/10.2105/AJPH.2011.300239 article 2012 ftcopenhagenunip https://doi.org/10.2105/AJPH.2011.300239 2023-11-09T00:10:53Z Objectives. To evaluate the effectiveness of the hepatitis B virus (HBV) vaccination program in Greenland, which targets children born to mothers who are positive for HBV surface antigen (HBsAg), we determined vaccination coverage, levels of postvaccination antibodies, and frequency of breakthrough infections in at-risk children. Methods. We conducted a population-based retrospective cohort study with data from nationwide registries. We identified all children born to HBsAgpositive mothers from 1992 to 2007 and collected data on their HBV vaccination status. In 2008 to 2010, we tested the children for HBV core antibody, HBsAg, and anti-HBsAg antibody (HBsAb). Results. Of 4050 pregnant women, 3.2% were HBsAg positive. Of 207 children born to these women, 20% received no vaccinations, and only 58% received at least 3 vaccinations. At follow-up, HBsAb levels in vaccinated children were much lower than expected, and 8 (6%) of 140 at-risk children had breakthrough infections, with 4 chronically infected (persistently HBsAg positive). Conclusions. The prevention program targeting children at risk for HBV in Greenland is ineffective. HBV vaccination should be included in the universal childhood vaccination program, and postvaccination HBsAb levels should be monitored. Article in Journal/Newspaper Greenland University of Copenhagen: Research Greenland American Journal of Public Health 102 2 277 284 |
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University of Copenhagen: Research |
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ftcopenhagenunip |
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English |
description |
Objectives. To evaluate the effectiveness of the hepatitis B virus (HBV) vaccination program in Greenland, which targets children born to mothers who are positive for HBV surface antigen (HBsAg), we determined vaccination coverage, levels of postvaccination antibodies, and frequency of breakthrough infections in at-risk children. Methods. We conducted a population-based retrospective cohort study with data from nationwide registries. We identified all children born to HBsAgpositive mothers from 1992 to 2007 and collected data on their HBV vaccination status. In 2008 to 2010, we tested the children for HBV core antibody, HBsAg, and anti-HBsAg antibody (HBsAb). Results. Of 4050 pregnant women, 3.2% were HBsAg positive. Of 207 children born to these women, 20% received no vaccinations, and only 58% received at least 3 vaccinations. At follow-up, HBsAb levels in vaccinated children were much lower than expected, and 8 (6%) of 140 at-risk children had breakthrough infections, with 4 chronically infected (persistently HBsAg positive). Conclusions. The prevention program targeting children at risk for HBV in Greenland is ineffective. HBV vaccination should be included in the universal childhood vaccination program, and postvaccination HBsAb levels should be monitored. |
format |
Article in Journal/Newspaper |
author |
Børresen, Malene L. Koch, Anders Biggar, Robert J. Ladefoged, Karin Melbye, Mads Wohlfahrt, Jan Krause, Tyra Grove |
spellingShingle |
Børresen, Malene L. Koch, Anders Biggar, Robert J. Ladefoged, Karin Melbye, Mads Wohlfahrt, Jan Krause, Tyra Grove Effectiveness of the targeted hepatitis B vaccination program in Greenland |
author_facet |
Børresen, Malene L. Koch, Anders Biggar, Robert J. Ladefoged, Karin Melbye, Mads Wohlfahrt, Jan Krause, Tyra Grove |
author_sort |
Børresen, Malene L. |
title |
Effectiveness of the targeted hepatitis B vaccination program in Greenland |
title_short |
Effectiveness of the targeted hepatitis B vaccination program in Greenland |
title_full |
Effectiveness of the targeted hepatitis B vaccination program in Greenland |
title_fullStr |
Effectiveness of the targeted hepatitis B vaccination program in Greenland |
title_full_unstemmed |
Effectiveness of the targeted hepatitis B vaccination program in Greenland |
title_sort |
effectiveness of the targeted hepatitis b vaccination program in greenland |
publishDate |
2012 |
url |
https://curis.ku.dk/portal/da/publications/effectiveness-of-the-targeted-hepatitis-b-vaccination-program-in-greenland(c3212895-e1eb-46b5-8592-a16d735a87ba).html https://doi.org/10.2105/AJPH.2011.300239 http://www.scopus.com/inward/record.url?scp=84857340273&partnerID=8YFLogxK |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Børresen , M L , Koch , A , Biggar , R J , Ladefoged , K , Melbye , M , Wohlfahrt , J & Krause , T G 2012 , ' Effectiveness of the targeted hepatitis B vaccination program in Greenland ' , American Journal of Public Health , vol. 102 , no. 2 , pp. 277-284 . https://doi.org/10.2105/AJPH.2011.300239 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.2105/AJPH.2011.300239 |
container_title |
American Journal of Public Health |
container_volume |
102 |
container_issue |
2 |
container_start_page |
277 |
op_container_end_page |
284 |
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1784271479526916096 |