Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample
A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relation b...
Published in: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
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Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2010
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Online Access: | https://curis.ku.dk/portal/da/publications/association-analysis-of-palb2-and-brca2-in-bipolar-disorder-and-schizophrenia-in-a-scandinavian-casecontrol-sample(b272d217-c445-41aa-802a-dc04cd5afd32).html https://doi.org/10.1002/ajmg.b.31098 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/b272d217-c445-41aa-802a-dc04cd5afd32 2024-05-12T08:05:47+00:00 Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample Tesli, Martin Athanasiu, Lavinia Mattingsdal, Morten Kähler, Anna K Gustafsson, Omar Andreassen, Bettina K Werge, Thomas Hansen, Thomas Mors, Ole Mellerup, Erling Koefoed, Pernille Jönsson, Erik G Agartz, Ingrid Melle, Ingrid Morken, Gunnar Djurovic, Srdjan Andreassen, Ole A 2010-10 https://curis.ku.dk/portal/da/publications/association-analysis-of-palb2-and-brca2-in-bipolar-disorder-and-schizophrenia-in-a-scandinavian-casecontrol-sample(b272d217-c445-41aa-802a-dc04cd5afd32).html https://doi.org/10.1002/ajmg.b.31098 eng eng info:eu-repo/semantics/restrictedAccess Tesli , M , Athanasiu , L , Mattingsdal , M , Kähler , A K , Gustafsson , O , Andreassen , B K , Werge , T , Hansen , T , Mors , O , Mellerup , E , Koefoed , P , Jönsson , E G , Agartz , I , Melle , I , Morken , G , Djurovic , S & Andreassen , O A 2010 , ' Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample ' , American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , vol. 153B , no. 7 , pp. 1276-82 . https://doi.org/10.1002/ajmg.b.31098 BRCA2 Protein Bipolar Disorder Case-Control Studies DNA Repair Genetic Predisposition to Disease Humans Iceland Neurogenesis Nuclear Proteins Polymorphism Single Nucleotide Scandinavia Schizophrenia Tumor Suppressor Proteins article 2010 ftcopenhagenunip https://doi.org/10.1002/ajmg.b.31098 2024-04-18T00:28:12Z A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relation between genetic variants in PALB2 and BRCA2 and BD. Due to increasing evidence of genetic overlap between BD and schizophrenia (SCZ), we also investigated association with SCZ. In a Scandinavian case-control sample (n¿=¿686/2,538) we found the BRCA2 SNP rs9567552 to be significantly associated with BD (Nominal P¿=¿0.00043). Additionally, we replicated the association between PALB2 SNP rs420259 and BD (Nominal P¿=¿0.025). We then combined our sample with another Nordic case-control sample (n¿=¿435/11,491) from Iceland, and added results from the Wellcome Trust Case Control Consortium (WTCCC) (n¿=¿1,868/2,938) and the STEP-UCL/ED-DUB-STEP2 study (n¿=¿2,558/3,274) in a meta-analysis which revealed a P-value of 1.2¿×¿10(-5) for association between PALB2 SNP rs420259 and BD (n¿=¿5,547/20,241). Neither the PALB2 SNP rs420259 nor the BRCA2 SNP rs9567552 were nominally significantly associated with the SCZ phenotype in our Scandinavian sample (n¿=¿781/2,839). Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. © 2010 Wiley-Liss, Inc. Article in Journal/Newspaper Iceland University of Copenhagen: Research American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B 7 1276 1282 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
BRCA2 Protein Bipolar Disorder Case-Control Studies DNA Repair Genetic Predisposition to Disease Humans Iceland Neurogenesis Nuclear Proteins Polymorphism Single Nucleotide Scandinavia Schizophrenia Tumor Suppressor Proteins |
spellingShingle |
BRCA2 Protein Bipolar Disorder Case-Control Studies DNA Repair Genetic Predisposition to Disease Humans Iceland Neurogenesis Nuclear Proteins Polymorphism Single Nucleotide Scandinavia Schizophrenia Tumor Suppressor Proteins Tesli, Martin Athanasiu, Lavinia Mattingsdal, Morten Kähler, Anna K Gustafsson, Omar Andreassen, Bettina K Werge, Thomas Hansen, Thomas Mors, Ole Mellerup, Erling Koefoed, Pernille Jönsson, Erik G Agartz, Ingrid Melle, Ingrid Morken, Gunnar Djurovic, Srdjan Andreassen, Ole A Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample |
topic_facet |
BRCA2 Protein Bipolar Disorder Case-Control Studies DNA Repair Genetic Predisposition to Disease Humans Iceland Neurogenesis Nuclear Proteins Polymorphism Single Nucleotide Scandinavia Schizophrenia Tumor Suppressor Proteins |
description |
A recent genome-wide association study (GWAS) found significant association between the PALB2 SNP rs420259 and bipolar disorder (BD). The intracellular functions of the expressed proteins from the breast cancer risk genes PALB2 and BRCA2 are closely related. Therefore, we investigated the relation between genetic variants in PALB2 and BRCA2 and BD. Due to increasing evidence of genetic overlap between BD and schizophrenia (SCZ), we also investigated association with SCZ. In a Scandinavian case-control sample (n¿=¿686/2,538) we found the BRCA2 SNP rs9567552 to be significantly associated with BD (Nominal P¿=¿0.00043). Additionally, we replicated the association between PALB2 SNP rs420259 and BD (Nominal P¿=¿0.025). We then combined our sample with another Nordic case-control sample (n¿=¿435/11,491) from Iceland, and added results from the Wellcome Trust Case Control Consortium (WTCCC) (n¿=¿1,868/2,938) and the STEP-UCL/ED-DUB-STEP2 study (n¿=¿2,558/3,274) in a meta-analysis which revealed a P-value of 1.2¿×¿10(-5) for association between PALB2 SNP rs420259 and BD (n¿=¿5,547/20,241). Neither the PALB2 SNP rs420259 nor the BRCA2 SNP rs9567552 were nominally significantly associated with the SCZ phenotype in our Scandinavian sample (n¿=¿781/2,839). Our findings support PALB2 and BRCA2 as risk genes specifically for BD, and suggest that altered DNA repair related to neurogenesis may be involved in BD pathophysiology. © 2010 Wiley-Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Tesli, Martin Athanasiu, Lavinia Mattingsdal, Morten Kähler, Anna K Gustafsson, Omar Andreassen, Bettina K Werge, Thomas Hansen, Thomas Mors, Ole Mellerup, Erling Koefoed, Pernille Jönsson, Erik G Agartz, Ingrid Melle, Ingrid Morken, Gunnar Djurovic, Srdjan Andreassen, Ole A |
author_facet |
Tesli, Martin Athanasiu, Lavinia Mattingsdal, Morten Kähler, Anna K Gustafsson, Omar Andreassen, Bettina K Werge, Thomas Hansen, Thomas Mors, Ole Mellerup, Erling Koefoed, Pernille Jönsson, Erik G Agartz, Ingrid Melle, Ingrid Morken, Gunnar Djurovic, Srdjan Andreassen, Ole A |
author_sort |
Tesli, Martin |
title |
Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample |
title_short |
Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample |
title_full |
Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample |
title_fullStr |
Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample |
title_full_unstemmed |
Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample |
title_sort |
association analysis of palb2 and brca2 in bipolar disorder and schizophrenia in a scandinavian case-control sample |
publishDate |
2010 |
url |
https://curis.ku.dk/portal/da/publications/association-analysis-of-palb2-and-brca2-in-bipolar-disorder-and-schizophrenia-in-a-scandinavian-casecontrol-sample(b272d217-c445-41aa-802a-dc04cd5afd32).html https://doi.org/10.1002/ajmg.b.31098 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Tesli , M , Athanasiu , L , Mattingsdal , M , Kähler , A K , Gustafsson , O , Andreassen , B K , Werge , T , Hansen , T , Mors , O , Mellerup , E , Koefoed , P , Jönsson , E G , Agartz , I , Melle , I , Morken , G , Djurovic , S & Andreassen , O A 2010 , ' Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample ' , American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , vol. 153B , no. 7 , pp. 1276-82 . https://doi.org/10.1002/ajmg.b.31098 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1002/ajmg.b.31098 |
container_title |
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
container_volume |
153B |
container_issue |
7 |
container_start_page |
1276 |
op_container_end_page |
1282 |
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1798848155368816640 |