Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrich...

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Published in:Nature Genetics
Main Authors: Grarup, Niels, Moltke, Ida, Andersen, Mette Korre, Dalby, Maria, Vitting-Seerup, Kristoffer, Kern, Timo Sebastian, Mahendran, Yuvaraj, Jørsboe, Emil, Larsen, Christina Viskum Lytken, Dahl-Petersen, Inger Katrine, Gilly, Arthur, Suveges, Daniel, Dedoussis, George, Zeggini, Eleftheria, Pedersen, Oluf Borbye, Andersson, Robin, Bjerregaard, Peter, Jørgensen, Marit Eika, Albrechtsen, Anders, Hansen, Torben
Format: Article in Journal/Newspaper
Language:English
Published: 2018
Subjects:
greenlandic
Online Access:https://curis.ku.dk/portal/da/publications/lossoffunction-variants-in-adcy3-increase-risk-of-obesity-and-type-2-diabetes(b02114f3-f158-42ba-a481-074a2a859f45).html
https://doi.org/10.1038/s41588-017-0022-7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828106/pdf/emss-75137.pdf
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spelling ftcopenhagenunip:oai:pure.atira.dk:publications/b02114f3-f158-42ba-a481-074a2a859f45 2024-05-12T08:04:45+00:00 Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes Grarup, Niels Moltke, Ida Andersen, Mette Korre Dalby, Maria Vitting-Seerup, Kristoffer Kern, Timo Sebastian Mahendran, Yuvaraj Jørsboe, Emil Larsen, Christina Viskum Lytken Dahl-Petersen, Inger Katrine Gilly, Arthur Suveges, Daniel Dedoussis, George Zeggini, Eleftheria Pedersen, Oluf Borbye Andersson, Robin Bjerregaard, Peter Jørgensen, Marit Eika Albrechtsen, Anders Hansen, Torben 2018 https://curis.ku.dk/portal/da/publications/lossoffunction-variants-in-adcy3-increase-risk-of-obesity-and-type-2-diabetes(b02114f3-f158-42ba-a481-074a2a859f45).html https://doi.org/10.1038/s41588-017-0022-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828106/pdf/emss-75137.pdf eng eng info:eu-repo/semantics/openAccess Grarup , N , Moltke , I , Andersen , M K , Dalby , M , Vitting-Seerup , K , Kern , T S , Mahendran , Y , Jørsboe , E , Larsen , C V L , Dahl-Petersen , I K , Gilly , A , Suveges , D , Dedoussis , G , Zeggini , E , Pedersen , O B , Andersson , R , Bjerregaard , P , Jørgensen , M E , Albrechtsen , A & Hansen , T 2018 , ' Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes ' , Nature Genetics , vol. 50 , no. 2 , pp. 172-174 . https://doi.org/10.1038/s41588-017-0022-7 article 2018 ftcopenhagenunip https://doi.org/10.1038/s41588-017-0022-7 2024-04-18T00:28:14Z We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies. Article in Journal/Newspaper greenlandic University of Copenhagen: Research Nature Genetics 50 2 172 174
institution Open Polar
collection University of Copenhagen: Research
op_collection_id ftcopenhagenunip
language English
description We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.
format Article in Journal/Newspaper
author Grarup, Niels
Moltke, Ida
Andersen, Mette Korre
Dalby, Maria
Vitting-Seerup, Kristoffer
Kern, Timo Sebastian
Mahendran, Yuvaraj
Jørsboe, Emil
Larsen, Christina Viskum Lytken
Dahl-Petersen, Inger Katrine
Gilly, Arthur
Suveges, Daniel
Dedoussis, George
Zeggini, Eleftheria
Pedersen, Oluf Borbye
Andersson, Robin
Bjerregaard, Peter
Jørgensen, Marit Eika
Albrechtsen, Anders
Hansen, Torben
spellingShingle Grarup, Niels
Moltke, Ida
Andersen, Mette Korre
Dalby, Maria
Vitting-Seerup, Kristoffer
Kern, Timo Sebastian
Mahendran, Yuvaraj
Jørsboe, Emil
Larsen, Christina Viskum Lytken
Dahl-Petersen, Inger Katrine
Gilly, Arthur
Suveges, Daniel
Dedoussis, George
Zeggini, Eleftheria
Pedersen, Oluf Borbye
Andersson, Robin
Bjerregaard, Peter
Jørgensen, Marit Eika
Albrechtsen, Anders
Hansen, Torben
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
author_facet Grarup, Niels
Moltke, Ida
Andersen, Mette Korre
Dalby, Maria
Vitting-Seerup, Kristoffer
Kern, Timo Sebastian
Mahendran, Yuvaraj
Jørsboe, Emil
Larsen, Christina Viskum Lytken
Dahl-Petersen, Inger Katrine
Gilly, Arthur
Suveges, Daniel
Dedoussis, George
Zeggini, Eleftheria
Pedersen, Oluf Borbye
Andersson, Robin
Bjerregaard, Peter
Jørgensen, Marit Eika
Albrechtsen, Anders
Hansen, Torben
author_sort Grarup, Niels
title Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
title_short Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
title_full Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
title_fullStr Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
title_full_unstemmed Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
title_sort loss-of-function variants in adcy3 increase risk of obesity and type 2 diabetes
publishDate 2018
url https://curis.ku.dk/portal/da/publications/lossoffunction-variants-in-adcy3-increase-risk-of-obesity-and-type-2-diabetes(b02114f3-f158-42ba-a481-074a2a859f45).html
https://doi.org/10.1038/s41588-017-0022-7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828106/pdf/emss-75137.pdf
genre greenlandic
genre_facet greenlandic
op_source Grarup , N , Moltke , I , Andersen , M K , Dalby , M , Vitting-Seerup , K , Kern , T S , Mahendran , Y , Jørsboe , E , Larsen , C V L , Dahl-Petersen , I K , Gilly , A , Suveges , D , Dedoussis , G , Zeggini , E , Pedersen , O B , Andersson , R , Bjerregaard , P , Jørgensen , M E , Albrechtsen , A & Hansen , T 2018 , ' Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes ' , Nature Genetics , vol. 50 , no. 2 , pp. 172-174 . https://doi.org/10.1038/s41588-017-0022-7
op_rights info:eu-repo/semantics/openAccess
op_doi https://doi.org/10.1038/s41588-017-0022-7
container_title Nature Genetics
container_volume 50
container_issue 2
container_start_page 172
op_container_end_page 174
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