The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression
Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptation remains far from und...
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2014
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Online Access: | https://curis.ku.dk/portal/da/publications/the-elusive-nature-of-adaptive-mitochondrial-dna-evolution-of-an-arctic-lineage-prone-to-frequent-introgression(a74a8b6b-ac75-4409-99ea-2a46b3150584).html https://doi.org/10.1093/gbe/evu059 https://curis.ku.dk/ws/files/140306991/Genome_Biol_Evol_2014_Melo_Ferreira_886_96.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/a74a8b6b-ac75-4409-99ea-2a46b3150584 2024-05-19T07:33:11+00:00 The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression Melo-Ferreira, Jose Vilela, Joana Fonseca, Miguel M. Rodrigues da Fonseca, Rute Andreia Boursot, Pierre Alves, Paulo C. 2014 application/pdf https://curis.ku.dk/portal/da/publications/the-elusive-nature-of-adaptive-mitochondrial-dna-evolution-of-an-arctic-lineage-prone-to-frequent-introgression(a74a8b6b-ac75-4409-99ea-2a46b3150584).html https://doi.org/10.1093/gbe/evu059 https://curis.ku.dk/ws/files/140306991/Genome_Biol_Evol_2014_Melo_Ferreira_886_96.pdf eng eng info:eu-repo/semantics/openAccess Melo-Ferreira , J , Vilela , J , Fonseca , M M , Rodrigues da Fonseca , R A , Boursot , P & Alves , P C 2014 , ' The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression ' , Genome Biology and Evolution , vol. 6 , no. 4 , pp. 886-896 . https://doi.org/10.1093/gbe/evu059 article 2014 ftcopenhagenunip https://doi.org/10.1093/gbe/evu059 2024-05-02T00:33:09Z Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptation remains far from understood. Hares (Lepus spp.) are privileged models to study the impact of natural selection on mitogenomic evolution because 1) species are adapted to contrasting environments, including arctic, with different metabolic pressures, and 2) mtDNA introgression from arctic into temperate species is widespread. Here, we analyzed the sequences of 11 complete mitogenomes (ten newly obtained) of hares of temperate and arctic origins (including two of arctic origin introgressed into temperate species). The analysis of patterns of codon substitutions along the reconstructed phylogeny showed evidence for positive selection in several codons in genes of the OXPHOS complexes, most notably affecting the arctic lineage. However, using theoretical models, no predictable effect of these differences was found on the structure and physicochemical properties of the encoded proteins, suggesting that the focus of selection may lie on complex interactions with nuclear encoded peptides. Also, a cloverleaf structure was detected in the control region only from the arctic mtDNA lineage, which may influence mtDNA replication and transcription. These results suggest that adaptation impacted the evolution of hare mtDNA and may have influenced the occurrence and consequences of the many reported cases of massive mtDNA introgression. However, the origin of adaptation remains elusive. Article in Journal/Newspaper Arctic Arctic University of Copenhagen: Research Genome Biology and Evolution 6 4 886 896 |
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Open Polar |
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University of Copenhagen: Research |
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ftcopenhagenunip |
language |
English |
description |
Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptation remains far from understood. Hares (Lepus spp.) are privileged models to study the impact of natural selection on mitogenomic evolution because 1) species are adapted to contrasting environments, including arctic, with different metabolic pressures, and 2) mtDNA introgression from arctic into temperate species is widespread. Here, we analyzed the sequences of 11 complete mitogenomes (ten newly obtained) of hares of temperate and arctic origins (including two of arctic origin introgressed into temperate species). The analysis of patterns of codon substitutions along the reconstructed phylogeny showed evidence for positive selection in several codons in genes of the OXPHOS complexes, most notably affecting the arctic lineage. However, using theoretical models, no predictable effect of these differences was found on the structure and physicochemical properties of the encoded proteins, suggesting that the focus of selection may lie on complex interactions with nuclear encoded peptides. Also, a cloverleaf structure was detected in the control region only from the arctic mtDNA lineage, which may influence mtDNA replication and transcription. These results suggest that adaptation impacted the evolution of hare mtDNA and may have influenced the occurrence and consequences of the many reported cases of massive mtDNA introgression. However, the origin of adaptation remains elusive. |
format |
Article in Journal/Newspaper |
author |
Melo-Ferreira, Jose Vilela, Joana Fonseca, Miguel M. Rodrigues da Fonseca, Rute Andreia Boursot, Pierre Alves, Paulo C. |
spellingShingle |
Melo-Ferreira, Jose Vilela, Joana Fonseca, Miguel M. Rodrigues da Fonseca, Rute Andreia Boursot, Pierre Alves, Paulo C. The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression |
author_facet |
Melo-Ferreira, Jose Vilela, Joana Fonseca, Miguel M. Rodrigues da Fonseca, Rute Andreia Boursot, Pierre Alves, Paulo C. |
author_sort |
Melo-Ferreira, Jose |
title |
The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression |
title_short |
The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression |
title_full |
The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression |
title_fullStr |
The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression |
title_full_unstemmed |
The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression |
title_sort |
elusive nature of adaptive mitochondrial dna evolution of an arctic lineage prone to frequent introgression |
publishDate |
2014 |
url |
https://curis.ku.dk/portal/da/publications/the-elusive-nature-of-adaptive-mitochondrial-dna-evolution-of-an-arctic-lineage-prone-to-frequent-introgression(a74a8b6b-ac75-4409-99ea-2a46b3150584).html https://doi.org/10.1093/gbe/evu059 https://curis.ku.dk/ws/files/140306991/Genome_Biol_Evol_2014_Melo_Ferreira_886_96.pdf |
genre |
Arctic Arctic |
genre_facet |
Arctic Arctic |
op_source |
Melo-Ferreira , J , Vilela , J , Fonseca , M M , Rodrigues da Fonseca , R A , Boursot , P & Alves , P C 2014 , ' The elusive nature of adaptive mitochondrial DNA evolution of an Arctic lineage prone to frequent introgression ' , Genome Biology and Evolution , vol. 6 , no. 4 , pp. 886-896 . https://doi.org/10.1093/gbe/evu059 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1093/gbe/evu059 |
container_title |
Genome Biology and Evolution |
container_volume |
6 |
container_issue |
4 |
container_start_page |
886 |
op_container_end_page |
896 |
_version_ |
1799471295213076480 |