Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children
Objective. In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish...
Published in: | International Journal of Circumpolar Health |
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2013
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Online Access: | https://curis.ku.dk/portal/da/publications/ethnic-differences-in-leptin-and-adiponectin-levels-between-greenlandic-inuit-and-danish-children(97c60add-c152-45f7-bba0-55a31c66eacf).html https://doi.org/10.3402/ijch.v72i0.21458 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/97c60add-c152-45f7-bba0-55a31c66eacf 2023-05-15T15:55:28+02:00 Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children Munch-Andersen, Thor Sorensen, Kaspar Aachmann-Andersen, Niels-Jacob Aksglaede, Lise Juul, Anders Helge, Jørn Wulff 2013 https://curis.ku.dk/portal/da/publications/ethnic-differences-in-leptin-and-adiponectin-levels-between-greenlandic-inuit-and-danish-children(97c60add-c152-45f7-bba0-55a31c66eacf).html https://doi.org/10.3402/ijch.v72i0.21458 eng eng info:eu-repo/semantics/restrictedAccess Munch-Andersen , T , Sorensen , K , Aachmann-Andersen , N-J , Aksglaede , L , Juul , A & Helge , J W 2013 , ' Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children ' , International Journal of Circumpolar Health , vol. 72 , 21458 , pp. 1-7 . https://doi.org/10.3402/ijch.v72i0.21458 leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio article 2013 ftcopenhagenunip https://doi.org/10.3402/ijch.v72i0.21458 2021-09-23T17:31:04Z Objective. In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children. Methods. In total, 187 Inuit and 132 Danish children (5.7–17.1 years) had examinations of anthropometrics, body fat content, pubertal staging, fasting blood and aerobic fitness. Results. Plasma leptin was higher in Danish boys [3,774 (4,741–3,005)] [pg/mL unadjusted geometric mean (95% CI)] compared to both northern [2,076 (2,525–1,706)] (p<0.001) and southern (2,515 (3,137–2,016)) (p<0.001) living Inuit boys and higher in Danish girls [6,988 (8,353–5,847)] compared to southern living Inuit girls [4,910 (6,370–3,785)] (p=0.021) and tended to be higher compared to northern living Inuit girls [5,131 (6,444–4,085)] (p=0.052). Plasma adiponectin was higher for both Danish boys [22,359 (2,573–19,428)] [ng/mL unadjusted geometric mean (95% CI)] and girls [26,609 (28,994–24,420)] compared to southern living Inuit boys [15,306 (18,406–12,728)] and girls [18,864 (22,640–15,717)] (both p<0.001), respectively. All differences remained after adjustment for body fat percentage (BF%), aerobic fitness, age and puberty. The leptin/adiponectin ratio was higher in Danish boys and tended to be higher in Danish girls compared to northern living Inuit boys and girls, respectively. These differences were eliminated after adjustment for BF%, aerobic fitness, age and puberty. Conclusions. In contrast to our hypothesis, plasma leptin was higher in Danish children despite a more healthy metabolic profile compared to Inuit children. As expected, plasma adiponectin was lowest in Inuit children with the most adverse metabolic profile. Article in Journal/Newspaper Circumpolar Health greenlandic International Journal of Circumpolar Health inuit University of Copenhagen: Research International Journal of Circumpolar Health 72 1 21458 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio |
spellingShingle |
leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio Munch-Andersen, Thor Sorensen, Kaspar Aachmann-Andersen, Niels-Jacob Aksglaede, Lise Juul, Anders Helge, Jørn Wulff Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
topic_facet |
leptin adiponectin children metabolic syndrome ethnic differences Inuit leptin/adiponectin ratio |
description |
Objective. In a recent study, we found that Greenlandic Inuit children had a more adverse metabolic profile than Danish children. Aerobic fitness and adiposity could only partly account for the differences. Therefore, we set out to evaluate and compare plasma leptin and adiponectin levels in Danish and Inuit children. Methods. In total, 187 Inuit and 132 Danish children (5.7–17.1 years) had examinations of anthropometrics, body fat content, pubertal staging, fasting blood and aerobic fitness. Results. Plasma leptin was higher in Danish boys [3,774 (4,741–3,005)] [pg/mL unadjusted geometric mean (95% CI)] compared to both northern [2,076 (2,525–1,706)] (p<0.001) and southern (2,515 (3,137–2,016)) (p<0.001) living Inuit boys and higher in Danish girls [6,988 (8,353–5,847)] compared to southern living Inuit girls [4,910 (6,370–3,785)] (p=0.021) and tended to be higher compared to northern living Inuit girls [5,131 (6,444–4,085)] (p=0.052). Plasma adiponectin was higher for both Danish boys [22,359 (2,573–19,428)] [ng/mL unadjusted geometric mean (95% CI)] and girls [26,609 (28,994–24,420)] compared to southern living Inuit boys [15,306 (18,406–12,728)] and girls [18,864 (22,640–15,717)] (both p<0.001), respectively. All differences remained after adjustment for body fat percentage (BF%), aerobic fitness, age and puberty. The leptin/adiponectin ratio was higher in Danish boys and tended to be higher in Danish girls compared to northern living Inuit boys and girls, respectively. These differences were eliminated after adjustment for BF%, aerobic fitness, age and puberty. Conclusions. In contrast to our hypothesis, plasma leptin was higher in Danish children despite a more healthy metabolic profile compared to Inuit children. As expected, plasma adiponectin was lowest in Inuit children with the most adverse metabolic profile. |
format |
Article in Journal/Newspaper |
author |
Munch-Andersen, Thor Sorensen, Kaspar Aachmann-Andersen, Niels-Jacob Aksglaede, Lise Juul, Anders Helge, Jørn Wulff |
author_facet |
Munch-Andersen, Thor Sorensen, Kaspar Aachmann-Andersen, Niels-Jacob Aksglaede, Lise Juul, Anders Helge, Jørn Wulff |
author_sort |
Munch-Andersen, Thor |
title |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_short |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_full |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_fullStr |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_full_unstemmed |
Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children |
title_sort |
ethnic differences in leptin and adiponectin levels between greenlandic inuit and danish children |
publishDate |
2013 |
url |
https://curis.ku.dk/portal/da/publications/ethnic-differences-in-leptin-and-adiponectin-levels-between-greenlandic-inuit-and-danish-children(97c60add-c152-45f7-bba0-55a31c66eacf).html https://doi.org/10.3402/ijch.v72i0.21458 |
genre |
Circumpolar Health greenlandic International Journal of Circumpolar Health inuit |
genre_facet |
Circumpolar Health greenlandic International Journal of Circumpolar Health inuit |
op_source |
Munch-Andersen , T , Sorensen , K , Aachmann-Andersen , N-J , Aksglaede , L , Juul , A & Helge , J W 2013 , ' Ethnic differences in leptin and adiponectin levels between Greenlandic Inuit and Danish children ' , International Journal of Circumpolar Health , vol. 72 , 21458 , pp. 1-7 . https://doi.org/10.3402/ijch.v72i0.21458 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.3402/ijch.v72i0.21458 |
container_title |
International Journal of Circumpolar Health |
container_volume |
72 |
container_issue |
1 |
container_start_page |
21458 |
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1766390953077112832 |