Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations
Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effec...
Published in: | Chemosphere |
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Online Access: | https://curis.ku.dk/portal/da/publications/blood-serum-concentrations-of-perfluorinated-compounds-in-men-from-greenlandic-inuit-and-european-populations(8e694259-ae5b-4f11-83a2-dfb44e6dcf75).html https://doi.org/10.1016/j.chemosphere.2012.03.049 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/8e694259-ae5b-4f11-83a2-dfb44e6dcf75 2024-05-19T07:41:16+00:00 Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations Lindh, Christian H Rylander, Lars Toft, Gunnar Axmon, Anna Rignell-Hydbom, Anna Giwercman, Aleksander Pedersen, Henning S Góalczyk, Katarzyna Ludwicki, Jan K Zvyezday, Valentyna Vermeulen, Roel Lenters, Virissa Heederik, Dick Bonde, Jens Peter Jönsson, Bo A G 2012 https://curis.ku.dk/portal/da/publications/blood-serum-concentrations-of-perfluorinated-compounds-in-men-from-greenlandic-inuit-and-european-populations(8e694259-ae5b-4f11-83a2-dfb44e6dcf75).html https://doi.org/10.1016/j.chemosphere.2012.03.049 eng eng info:eu-repo/semantics/restrictedAccess Lindh , C H , Rylander , L , Toft , G , Axmon , A , Rignell-Hydbom , A , Giwercman , A , Pedersen , H S , Góalczyk , K , Ludwicki , J K , Zvyezday , V , Vermeulen , R , Lenters , V , Heederik , D , Bonde , J P & Jönsson , B A G 2012 , ' Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations ' , Chemosphere , vol. 88 , no. 11 , pp. 1269-75 . https://doi.org/10.1016/j.chemosphere.2012.03.049 article 2012 ftcopenhagenunip https://doi.org/10.1016/j.chemosphere.2012.03.049 2024-04-25T00:45:01Z Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effects in animal studies. The aim of the present study was to describe levels of PFCs in serum among Inuits from Greenland and inhabitants from Warsaw, Poland and Kharkiv, Ukraine. Furthermore, the aim was to define social- and lifestyle related determinants of exposure for these compounds. Serum levels of seven PFCs were analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The concentrations of PFOS and PFOA were the highest of all PFCs in all three populations with a total amount of almost 90% of the PFCs. The mean levels of PFOS and PFOA were in the Greenlandic Inuits 52 and 4.8 ng mL(-1), in Poland 19 and 5.2 ng mL(-1), and in Ukraine 8.1 and 1.9 ng mL(-1), respectively. Thus, levels of PFCs in the serum of Inuits on Greenland were among the highest described in a general population whereas the levels in Poland were similar to other industrialized countries. The exposure in Ukraine was rather low. In the Greenlandic Inuit population, intake of seafood, tea, age and area of living were significant determinants of PFOS concentrations and explained about 22% of the variation. For the other populations no strong determinants were found. Article in Journal/Newspaper Greenland greenlandic inuit inuits University of Copenhagen: Research Chemosphere 88 11 1269 1275 |
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Open Polar |
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University of Copenhagen: Research |
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ftcopenhagenunip |
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English |
description |
Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effects in animal studies. The aim of the present study was to describe levels of PFCs in serum among Inuits from Greenland and inhabitants from Warsaw, Poland and Kharkiv, Ukraine. Furthermore, the aim was to define social- and lifestyle related determinants of exposure for these compounds. Serum levels of seven PFCs were analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The concentrations of PFOS and PFOA were the highest of all PFCs in all three populations with a total amount of almost 90% of the PFCs. The mean levels of PFOS and PFOA were in the Greenlandic Inuits 52 and 4.8 ng mL(-1), in Poland 19 and 5.2 ng mL(-1), and in Ukraine 8.1 and 1.9 ng mL(-1), respectively. Thus, levels of PFCs in the serum of Inuits on Greenland were among the highest described in a general population whereas the levels in Poland were similar to other industrialized countries. The exposure in Ukraine was rather low. In the Greenlandic Inuit population, intake of seafood, tea, age and area of living were significant determinants of PFOS concentrations and explained about 22% of the variation. For the other populations no strong determinants were found. |
format |
Article in Journal/Newspaper |
author |
Lindh, Christian H Rylander, Lars Toft, Gunnar Axmon, Anna Rignell-Hydbom, Anna Giwercman, Aleksander Pedersen, Henning S Góalczyk, Katarzyna Ludwicki, Jan K Zvyezday, Valentyna Vermeulen, Roel Lenters, Virissa Heederik, Dick Bonde, Jens Peter Jönsson, Bo A G |
spellingShingle |
Lindh, Christian H Rylander, Lars Toft, Gunnar Axmon, Anna Rignell-Hydbom, Anna Giwercman, Aleksander Pedersen, Henning S Góalczyk, Katarzyna Ludwicki, Jan K Zvyezday, Valentyna Vermeulen, Roel Lenters, Virissa Heederik, Dick Bonde, Jens Peter Jönsson, Bo A G Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations |
author_facet |
Lindh, Christian H Rylander, Lars Toft, Gunnar Axmon, Anna Rignell-Hydbom, Anna Giwercman, Aleksander Pedersen, Henning S Góalczyk, Katarzyna Ludwicki, Jan K Zvyezday, Valentyna Vermeulen, Roel Lenters, Virissa Heederik, Dick Bonde, Jens Peter Jönsson, Bo A G |
author_sort |
Lindh, Christian H |
title |
Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations |
title_short |
Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations |
title_full |
Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations |
title_fullStr |
Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations |
title_full_unstemmed |
Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations |
title_sort |
blood serum concentrations of perfluorinated compounds in men from greenlandic inuit and european populations |
publishDate |
2012 |
url |
https://curis.ku.dk/portal/da/publications/blood-serum-concentrations-of-perfluorinated-compounds-in-men-from-greenlandic-inuit-and-european-populations(8e694259-ae5b-4f11-83a2-dfb44e6dcf75).html https://doi.org/10.1016/j.chemosphere.2012.03.049 |
genre |
Greenland greenlandic inuit inuits |
genre_facet |
Greenland greenlandic inuit inuits |
op_source |
Lindh , C H , Rylander , L , Toft , G , Axmon , A , Rignell-Hydbom , A , Giwercman , A , Pedersen , H S , Góalczyk , K , Ludwicki , J K , Zvyezday , V , Vermeulen , R , Lenters , V , Heederik , D , Bonde , J P & Jönsson , B A G 2012 , ' Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations ' , Chemosphere , vol. 88 , no. 11 , pp. 1269-75 . https://doi.org/10.1016/j.chemosphere.2012.03.049 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.chemosphere.2012.03.049 |
container_title |
Chemosphere |
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88 |
container_issue |
11 |
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1269 |
op_container_end_page |
1275 |
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1799480861191569408 |