COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark
Background: Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence of physical symptoms in relation to acute illness severity...
Published in: | The Lancet Regional Health - Europe |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2023
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Online Access: | https://curis.ku.dk/portal/da/publications/covid19-illness-severity-and-2year-prevalence-of-physical-symptoms(8a259b7a-7648-4d16-a3ea-47f342996082).html https://doi.org/10.1016/j.lanepe.2023.100756 https://curis.ku.dk/ws/files/375057808/1_s2.0_S2666776223001758_main.pdf |
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Cohort COVID-19 Long covid Physical symptom |
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Cohort COVID-19 Long covid Physical symptom Shen, Qing Joyce, Emily E. Ebrahimi, Omid V. Didriksen, Maria Lovik, Anikó Sævarsdóttir, Karen Sól Magnúsdóttir, Ingibjörg Mikkelsen, Dorte Helenius Unnarsdóttir, Anna Bára Hauksdóttir, Arna Hoffart, Asle Kähler, Anna K. Thórdardóttir, Edda Björk Eythórsson, Elías Frans, Emma M. Tómasson, Gunnar Ask, Helga Hardardóttir, Hrönn Jakobsdóttir, Jóhanna Lehto, Kelli Lu, Li Andreassen, Ole A. Sullivan, Patrick F. Pálsson, Runólfur Erikstrup, Christian Ostrowski, Sisse Rye Werge, Thomas Aspelund, Thor Pedersen, Ole B. V. Johnson, Sverre Urnes Fang, Fang Valdimarsdóttir, Unnur Anna COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark |
topic_facet |
Cohort COVID-19 Long covid Physical symptom |
description |
Background: Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence of physical symptoms in relation to acute illness severity up to more than 2-years after diagnosis of COVID-19. Methods: This multinational study included 64,880 adult participants from Iceland, Sweden, Denmark, and Norway with self-reported data on COVID-19 and physical symptoms from April 2020 to August 2022. We compared the prevalence of 15 physical symptoms, measured by the Patient Health Questionnaire (PHQ-15), among individuals with or without a confirmed COVID-19 diagnosis, by acute illness severity, and by time since diagnosis. We additionally assessed the change in symptoms in a subset of Swedish adults with repeated measures, before and after COVID-19 diagnosis. Findings: During up to 27 months of follow-up, 34.5% participants (22,382/64,880) were diagnosed with COVID-19. Individuals who were diagnosed with COVID-19, compared to those not diagnosed, had an overall 37% higher prevalence of severe physical symptom burden (PHQ-15 score ≥15, adjusted prevalence ratio [PR] 1.37 [95% confidence interval [CI] 1.23–1.52]). The prevalence was associated with acute COVID-19 severity: individuals bedridden for seven days or longer presented with the highest prevalence (PR 2.25 [1.85–2.74]), while individuals never bedridden presented with similar prevalence as individuals not diagnosed with COVID-19 (PR 0.92 [0.68–1.24]). The prevalence was statistically significantly elevated among individuals diagnosed with COVID-19 for eight of the fifteen measured symptoms: shortness of breath, chest pain, dizziness, heart racing, headaches, low energy/fatigue, trouble sleeping, and back pain. The analysis of repeated measurements rendered similar results as the main analysis. Interpretation: These data suggest an elevated prevalence of some, but not all, physical symptoms during up to ... |
format |
Article in Journal/Newspaper |
author |
Shen, Qing Joyce, Emily E. Ebrahimi, Omid V. Didriksen, Maria Lovik, Anikó Sævarsdóttir, Karen Sól Magnúsdóttir, Ingibjörg Mikkelsen, Dorte Helenius Unnarsdóttir, Anna Bára Hauksdóttir, Arna Hoffart, Asle Kähler, Anna K. Thórdardóttir, Edda Björk Eythórsson, Elías Frans, Emma M. Tómasson, Gunnar Ask, Helga Hardardóttir, Hrönn Jakobsdóttir, Jóhanna Lehto, Kelli Lu, Li Andreassen, Ole A. Sullivan, Patrick F. Pálsson, Runólfur Erikstrup, Christian Ostrowski, Sisse Rye Werge, Thomas Aspelund, Thor Pedersen, Ole B. V. Johnson, Sverre Urnes Fang, Fang Valdimarsdóttir, Unnur Anna |
author_facet |
Shen, Qing Joyce, Emily E. Ebrahimi, Omid V. Didriksen, Maria Lovik, Anikó Sævarsdóttir, Karen Sól Magnúsdóttir, Ingibjörg Mikkelsen, Dorte Helenius Unnarsdóttir, Anna Bára Hauksdóttir, Arna Hoffart, Asle Kähler, Anna K. Thórdardóttir, Edda Björk Eythórsson, Elías Frans, Emma M. Tómasson, Gunnar Ask, Helga Hardardóttir, Hrönn Jakobsdóttir, Jóhanna Lehto, Kelli Lu, Li Andreassen, Ole A. Sullivan, Patrick F. Pálsson, Runólfur Erikstrup, Christian Ostrowski, Sisse Rye Werge, Thomas Aspelund, Thor Pedersen, Ole B. V. Johnson, Sverre Urnes Fang, Fang Valdimarsdóttir, Unnur Anna |
author_sort |
Shen, Qing |
title |
COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark |
title_short |
COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark |
title_full |
COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark |
title_fullStr |
COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark |
title_full_unstemmed |
COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark |
title_sort |
covid-19 illness severity and 2-year prevalence of physical symptoms:an observational study in iceland, sweden, norway and denmark |
publishDate |
2023 |
url |
https://curis.ku.dk/portal/da/publications/covid19-illness-severity-and-2year-prevalence-of-physical-symptoms(8a259b7a-7648-4d16-a3ea-47f342996082).html https://doi.org/10.1016/j.lanepe.2023.100756 https://curis.ku.dk/ws/files/375057808/1_s2.0_S2666776223001758_main.pdf |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Shen , Q , Joyce , E E , Ebrahimi , O V , Didriksen , M , Lovik , A , Sævarsdóttir , K S , Magnúsdóttir , I , Mikkelsen , D H , Unnarsdóttir , A B , Hauksdóttir , A , Hoffart , A , Kähler , A K , Thórdardóttir , E B , Eythórsson , E , Frans , E M , Tómasson , G , Ask , H , Hardardóttir , H , Jakobsdóttir , J , Lehto , K , Lu , L , Andreassen , O A , Sullivan , P F , Pálsson , R , Erikstrup , C , Ostrowski , S R , Werge , T , Aspelund , T , Pedersen , O B V , Johnson , S U , Fang , F & Valdimarsdóttir , U A 2023 , ' COVID-19 illness severity and 2-year prevalence of physical symptoms : an observational study in Iceland, Sweden, Norway and Denmark ' , The Lancet Regional Health - Europe , vol. 35 , 100756 . https://doi.org/10.1016/j.lanepe.2023.100756 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.lanepe.2023.100756 |
container_title |
The Lancet Regional Health - Europe |
container_volume |
35 |
container_start_page |
100756 |
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1801378051209035776 |
spelling |
ftcopenhagenunip:oai:pure.atira.dk:publications/8a259b7a-7648-4d16-a3ea-47f342996082 2024-06-09T07:47:08+00:00 COVID-19 illness severity and 2-year prevalence of physical symptoms:an observational study in Iceland, Sweden, Norway and Denmark Shen, Qing Joyce, Emily E. Ebrahimi, Omid V. Didriksen, Maria Lovik, Anikó Sævarsdóttir, Karen Sól Magnúsdóttir, Ingibjörg Mikkelsen, Dorte Helenius Unnarsdóttir, Anna Bára Hauksdóttir, Arna Hoffart, Asle Kähler, Anna K. Thórdardóttir, Edda Björk Eythórsson, Elías Frans, Emma M. Tómasson, Gunnar Ask, Helga Hardardóttir, Hrönn Jakobsdóttir, Jóhanna Lehto, Kelli Lu, Li Andreassen, Ole A. Sullivan, Patrick F. Pálsson, Runólfur Erikstrup, Christian Ostrowski, Sisse Rye Werge, Thomas Aspelund, Thor Pedersen, Ole B. V. Johnson, Sverre Urnes Fang, Fang Valdimarsdóttir, Unnur Anna 2023 application/pdf https://curis.ku.dk/portal/da/publications/covid19-illness-severity-and-2year-prevalence-of-physical-symptoms(8a259b7a-7648-4d16-a3ea-47f342996082).html https://doi.org/10.1016/j.lanepe.2023.100756 https://curis.ku.dk/ws/files/375057808/1_s2.0_S2666776223001758_main.pdf eng eng info:eu-repo/semantics/openAccess Shen , Q , Joyce , E E , Ebrahimi , O V , Didriksen , M , Lovik , A , Sævarsdóttir , K S , Magnúsdóttir , I , Mikkelsen , D H , Unnarsdóttir , A B , Hauksdóttir , A , Hoffart , A , Kähler , A K , Thórdardóttir , E B , Eythórsson , E , Frans , E M , Tómasson , G , Ask , H , Hardardóttir , H , Jakobsdóttir , J , Lehto , K , Lu , L , Andreassen , O A , Sullivan , P F , Pálsson , R , Erikstrup , C , Ostrowski , S R , Werge , T , Aspelund , T , Pedersen , O B V , Johnson , S U , Fang , F & Valdimarsdóttir , U A 2023 , ' COVID-19 illness severity and 2-year prevalence of physical symptoms : an observational study in Iceland, Sweden, Norway and Denmark ' , The Lancet Regional Health - Europe , vol. 35 , 100756 . https://doi.org/10.1016/j.lanepe.2023.100756 Cohort COVID-19 Long covid Physical symptom article 2023 ftcopenhagenunip https://doi.org/10.1016/j.lanepe.2023.100756 2024-05-16T11:29:31Z Background: Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess the prevalence of physical symptoms in relation to acute illness severity up to more than 2-years after diagnosis of COVID-19. Methods: This multinational study included 64,880 adult participants from Iceland, Sweden, Denmark, and Norway with self-reported data on COVID-19 and physical symptoms from April 2020 to August 2022. We compared the prevalence of 15 physical symptoms, measured by the Patient Health Questionnaire (PHQ-15), among individuals with or without a confirmed COVID-19 diagnosis, by acute illness severity, and by time since diagnosis. We additionally assessed the change in symptoms in a subset of Swedish adults with repeated measures, before and after COVID-19 diagnosis. Findings: During up to 27 months of follow-up, 34.5% participants (22,382/64,880) were diagnosed with COVID-19. Individuals who were diagnosed with COVID-19, compared to those not diagnosed, had an overall 37% higher prevalence of severe physical symptom burden (PHQ-15 score ≥15, adjusted prevalence ratio [PR] 1.37 [95% confidence interval [CI] 1.23–1.52]). The prevalence was associated with acute COVID-19 severity: individuals bedridden for seven days or longer presented with the highest prevalence (PR 2.25 [1.85–2.74]), while individuals never bedridden presented with similar prevalence as individuals not diagnosed with COVID-19 (PR 0.92 [0.68–1.24]). The prevalence was statistically significantly elevated among individuals diagnosed with COVID-19 for eight of the fifteen measured symptoms: shortness of breath, chest pain, dizziness, heart racing, headaches, low energy/fatigue, trouble sleeping, and back pain. The analysis of repeated measurements rendered similar results as the main analysis. Interpretation: These data suggest an elevated prevalence of some, but not all, physical symptoms during up to ... Article in Journal/Newspaper Iceland University of Copenhagen: Research Norway The Lancet Regional Health - Europe 35 100756 |