Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds
As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control...
Published in: | Ecotoxicology and Environmental Safety |
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2011
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Online Access: | https://curis.ku.dk/portal/da/publications/alterations-in-thyroid-hormone-status-in-greenland-sledge-dogs-exposed-to-whale-blubber-contaminated-with-organohalogen-compounds(7daed010-e0c2-11df-b6d2-000ea68e967b).html https://doi.org/10.1016/j.ecoenv.2010.08.040 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/7daed010-e0c2-11df-b6d2-000ea68e967b 2024-05-19T07:41:22+00:00 Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J. Jensen, Asger Lundorff Stige Hansen, Signe Jenssen, Bjørn Munro Grandjean, Philippe 2011 https://curis.ku.dk/portal/da/publications/alterations-in-thyroid-hormone-status-in-greenland-sledge-dogs-exposed-to-whale-blubber-contaminated-with-organohalogen-compounds(7daed010-e0c2-11df-b6d2-000ea68e967b).html https://doi.org/10.1016/j.ecoenv.2010.08.040 eng eng info:eu-repo/semantics/restrictedAccess Kirkegaard , M , Sonne , C , Dietz , R , Letcher , R J , Jensen , A L , Stige Hansen , S , Jenssen , B M & Grandjean , P 2011 , ' Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds ' , Ecotoxicology and Environmental Safety , vol. 74 , no. 1 , pp. 157-163 . https://doi.org/10.1016/j.ecoenv.2010.08.040 article 2011 ftcopenhagenunip https://doi.org/10.1016/j.ecoenv.2010.08.040 2024-04-25T00:45:00Z As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics. Article in Journal/Newspaper Greenland minke whale University of Copenhagen: Research Ecotoxicology and Environmental Safety 74 1 157 163 |
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Open Polar |
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University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
As a model of high trophic level carnivores, sledge dogs were fed from 2 to 18 months of age with minke whale blubber containing organohalogen compounds (OHC) corresponding to 128µg PCB/day. Controls were fed uncontaminated porcine fat. Thyroid hormone levels were assessed in 7 exposed and 7 control sister bitches (sampled at age 6-18 months) and 4 exposed and 4 control pups, fed the same diet as their mothers (sampled age 3-12 months). Lower free and total T3 and T4 were seen in exposed vs. control bitches beyond 10 months of age, and total T3 was lower through 3-12 months of age in exposed pups. A negative correlation with thyroid gland weight was significant for SDDT, as was a positive association with total T3 for dieldrin. This study therefore supports observational data that OHCs may adversely affect thyroid functions, and it suggests that OHC exposure duration of 10 months or more may be required for current OHC contamination levels to result in detectable adverse effects on thyroid hormone dynamics. |
format |
Article in Journal/Newspaper |
author |
Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J. Jensen, Asger Lundorff Stige Hansen, Signe Jenssen, Bjørn Munro Grandjean, Philippe |
spellingShingle |
Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J. Jensen, Asger Lundorff Stige Hansen, Signe Jenssen, Bjørn Munro Grandjean, Philippe Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds |
author_facet |
Kirkegaard, Maja Sonne, Christian Dietz, Rune Letcher, Robert J. Jensen, Asger Lundorff Stige Hansen, Signe Jenssen, Bjørn Munro Grandjean, Philippe |
author_sort |
Kirkegaard, Maja |
title |
Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds |
title_short |
Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds |
title_full |
Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds |
title_fullStr |
Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds |
title_full_unstemmed |
Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds |
title_sort |
alterations in thyroid hormone status in greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds |
publishDate |
2011 |
url |
https://curis.ku.dk/portal/da/publications/alterations-in-thyroid-hormone-status-in-greenland-sledge-dogs-exposed-to-whale-blubber-contaminated-with-organohalogen-compounds(7daed010-e0c2-11df-b6d2-000ea68e967b).html https://doi.org/10.1016/j.ecoenv.2010.08.040 |
genre |
Greenland minke whale |
genre_facet |
Greenland minke whale |
op_source |
Kirkegaard , M , Sonne , C , Dietz , R , Letcher , R J , Jensen , A L , Stige Hansen , S , Jenssen , B M & Grandjean , P 2011 , ' Alterations in thyroid hormone status in Greenland sledge dogs exposed to whale blubber contaminated with organohalogen compounds ' , Ecotoxicology and Environmental Safety , vol. 74 , no. 1 , pp. 157-163 . https://doi.org/10.1016/j.ecoenv.2010.08.040 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.ecoenv.2010.08.040 |
container_title |
Ecotoxicology and Environmental Safety |
container_volume |
74 |
container_issue |
1 |
container_start_page |
157 |
op_container_end_page |
163 |
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1799480959005884416 |