Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland
Vitamin D deficiency has been associated with increased risk of tuberculosis (TB). Changes from a traditional to a Westernised diet among Greenlanders have resulted in reduced serum vitamin D, leading to considerations of whether preventive vitamin D supplementation should be introduced. The associa...
Published in: | British Journal of Nutrition |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2010
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Online Access: | https://curis.ku.dk/portal/da/publications/both-high-and-low-serum-vitamin-d-concentrations-are-associated-with-tuberculosis(78188d4c-35fa-4680-8f8a-f25f38e76d7a).html https://doi.org/10.1017/S0007114510002333 http://www.scopus.com/inward/record.url?scp=78649982896&partnerID=8YFLogxK |
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ftcopenhagenunip:oai:pure.atira.dk:publications/78188d4c-35fa-4680-8f8a-f25f38e76d7a 2023-12-17T10:30:53+01:00 Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland Nielsen, Nina O. Skifte, Turid Andersson, Mikael Wohlfahrt, Jan Sborg, Bolette Koch, Anders Melbye, Mads Ladefoged, Karin 2010-11-28 https://curis.ku.dk/portal/da/publications/both-high-and-low-serum-vitamin-d-concentrations-are-associated-with-tuberculosis(78188d4c-35fa-4680-8f8a-f25f38e76d7a).html https://doi.org/10.1017/S0007114510002333 http://www.scopus.com/inward/record.url?scp=78649982896&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Nielsen , N O , Skifte , T , Andersson , M , Wohlfahrt , J , Sborg , B , Koch , A , Melbye , M & Ladefoged , K 2010 , ' Both high and low serum vitamin D concentrations are associated with tuberculosis : A case-control study in Greenland ' , British Journal of Nutrition , vol. 104 , no. 10 , pp. 1487-1491 . https://doi.org/10.1017/S0007114510002333 Case-control studies Greenland Odds ratios Tuberculosis Vitamin D article 2010 ftcopenhagenunip https://doi.org/10.1017/S0007114510002333 2023-11-23T00:12:17Z Vitamin D deficiency has been associated with increased risk of tuberculosis (TB). Changes from a traditional to a Westernised diet among Greenlanders have resulted in reduced serum vitamin D, leading to considerations of whether preventive vitamin D supplementation should be introduced. The association between vitamin D status and TB was examined to assess the feasibility of vitamin D supplementation in Greenland. This was examined in a case-control study involving seventy-two matched pairs of TB patients (cases) and controls aged 8-74 years. Cases were diagnosed with TB during 2004-6 based on clinical findings in combination with either (1) positive Mycobacterium tuberculosis culture, (2) characteristic X-ray abnormalities together with a positive tuberculin skin test or a positive interferon- release assay or (3) characteristic histology. Controls were individually matched on age (±5 years), sex and district. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured and OR of TB were the outcome. Compared with individuals with 25(OH)D concentrations between 75 and 140nmol/l, individuals with concentrations<75nmol/l (OR 65; 95% CI 18, 235) or>140nmol/l (OR 65; 95% CI 19, 222) had higher risks of active TB (P=0003; adjustment for alcohol and ethnicity). Supplementing individuals with low vitamin D to normalise serum 25(OH)D concentrations was estimated to result in a 29% reduction in the number of TB cases. The study indicated that vitamin D supplementation may be beneficial to individuals with insufficient vitamin D concentrations but may increase the risk of TB among individuals with normal or high concentrations. Article in Journal/Newspaper Greenland greenlander* University of Copenhagen: Research Greenland British Journal of Nutrition 104 10 1487 1491 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Case-control studies Greenland Odds ratios Tuberculosis Vitamin D |
spellingShingle |
Case-control studies Greenland Odds ratios Tuberculosis Vitamin D Nielsen, Nina O. Skifte, Turid Andersson, Mikael Wohlfahrt, Jan Sborg, Bolette Koch, Anders Melbye, Mads Ladefoged, Karin Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland |
topic_facet |
Case-control studies Greenland Odds ratios Tuberculosis Vitamin D |
description |
Vitamin D deficiency has been associated with increased risk of tuberculosis (TB). Changes from a traditional to a Westernised diet among Greenlanders have resulted in reduced serum vitamin D, leading to considerations of whether preventive vitamin D supplementation should be introduced. The association between vitamin D status and TB was examined to assess the feasibility of vitamin D supplementation in Greenland. This was examined in a case-control study involving seventy-two matched pairs of TB patients (cases) and controls aged 8-74 years. Cases were diagnosed with TB during 2004-6 based on clinical findings in combination with either (1) positive Mycobacterium tuberculosis culture, (2) characteristic X-ray abnormalities together with a positive tuberculin skin test or a positive interferon- release assay or (3) characteristic histology. Controls were individually matched on age (±5 years), sex and district. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured and OR of TB were the outcome. Compared with individuals with 25(OH)D concentrations between 75 and 140nmol/l, individuals with concentrations<75nmol/l (OR 65; 95% CI 18, 235) or>140nmol/l (OR 65; 95% CI 19, 222) had higher risks of active TB (P=0003; adjustment for alcohol and ethnicity). Supplementing individuals with low vitamin D to normalise serum 25(OH)D concentrations was estimated to result in a 29% reduction in the number of TB cases. The study indicated that vitamin D supplementation may be beneficial to individuals with insufficient vitamin D concentrations but may increase the risk of TB among individuals with normal or high concentrations. |
format |
Article in Journal/Newspaper |
author |
Nielsen, Nina O. Skifte, Turid Andersson, Mikael Wohlfahrt, Jan Sborg, Bolette Koch, Anders Melbye, Mads Ladefoged, Karin |
author_facet |
Nielsen, Nina O. Skifte, Turid Andersson, Mikael Wohlfahrt, Jan Sborg, Bolette Koch, Anders Melbye, Mads Ladefoged, Karin |
author_sort |
Nielsen, Nina O. |
title |
Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland |
title_short |
Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland |
title_full |
Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland |
title_fullStr |
Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland |
title_full_unstemmed |
Both high and low serum vitamin D concentrations are associated with tuberculosis:A case-control study in Greenland |
title_sort |
both high and low serum vitamin d concentrations are associated with tuberculosis:a case-control study in greenland |
publishDate |
2010 |
url |
https://curis.ku.dk/portal/da/publications/both-high-and-low-serum-vitamin-d-concentrations-are-associated-with-tuberculosis(78188d4c-35fa-4680-8f8a-f25f38e76d7a).html https://doi.org/10.1017/S0007114510002333 http://www.scopus.com/inward/record.url?scp=78649982896&partnerID=8YFLogxK |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlander* |
genre_facet |
Greenland greenlander* |
op_source |
Nielsen , N O , Skifte , T , Andersson , M , Wohlfahrt , J , Sborg , B , Koch , A , Melbye , M & Ladefoged , K 2010 , ' Both high and low serum vitamin D concentrations are associated with tuberculosis : A case-control study in Greenland ' , British Journal of Nutrition , vol. 104 , no. 10 , pp. 1487-1491 . https://doi.org/10.1017/S0007114510002333 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1017/S0007114510002333 |
container_title |
British Journal of Nutrition |
container_volume |
104 |
container_issue |
10 |
container_start_page |
1487 |
op_container_end_page |
1491 |
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1785583995701952512 |