Grey wolf genomic history reveals a dual ancestry of dogs
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when an...
Published in: | Nature |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2022
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Online Access: | https://curis.ku.dk/portal/da/publications/grey-wolf-genomic-history-reveals-a-dual-ancestry-of-dogs(56acb259-71bf-4a15-8ca4-ec29700175a3).html https://doi.org/10.1038/s41586-022-04824-9 https://curis.ku.dk/ws/files/321964410/s41586_022_04824_9.pdf |
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English |
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The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived 1–8 . Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. |
format |
Article in Journal/Newspaper |
author |
Bergström, Anders Stanton, David W. G. Taron, Ulrike H. Frantz, Laurent Sinding, Mikkel Holger S. Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophélie Girdland-Flink, Linus Fernandes, Daniel M. Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V. Ramos-Madrigal, Jazmin Feuerborn, Tatiana R. Reiter, Ella Gretzinger, Joscha Münzel, Susanne C. Swali, Pooja Conard, Nicholas J. Carøe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Hervé Brace, Selina Carden, Ruth F. Drucker, Dorothée G Fedorov, Sergey Gasparik, Mihály Germonpré, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T. Ivanova, Varvara V. Janssens, Luc Jennings, Richard P. Kasparov, Aleksei K. Kirillova, Irina V. Kurmaniyazov, Islam Kuzmin, Yaroslav V. Kosintsev, Pavel A. Lázničková-Galetová, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O’Drisceoil, Cóilín Orlando, Ludovic Outram, Alan Pavlova, Elena Y. Perri, Angela R. Pilot, Małgorzata Pitulko, Vladimir V. Plotnikov, Valerii V. Protopopov, Albert V. Rehazek, André Sablin, Mikhail Seguin-Orlando, Andaine Storå, Jan Verjux, Christian Zaibert, Victor F. Zazula, Grant Crombé, Philippe Hansen, Anders J. Willerslev, Eske Leonard, Jennifer A. Götherström, Anders Pinhasi, Ron Schuenemann, Verena J. Hofreiter, Michael Gilbert, M. Thomas P. Shapiro, Beth Larson, Greger Krause, Johannes Dalén, Love Skoglund, Pontus |
spellingShingle |
Bergström, Anders Stanton, David W. G. Taron, Ulrike H. Frantz, Laurent Sinding, Mikkel Holger S. Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophélie Girdland-Flink, Linus Fernandes, Daniel M. Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V. Ramos-Madrigal, Jazmin Feuerborn, Tatiana R. Reiter, Ella Gretzinger, Joscha Münzel, Susanne C. Swali, Pooja Conard, Nicholas J. Carøe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Hervé Brace, Selina Carden, Ruth F. Drucker, Dorothée G Fedorov, Sergey Gasparik, Mihály Germonpré, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T. Ivanova, Varvara V. Janssens, Luc Jennings, Richard P. Kasparov, Aleksei K. Kirillova, Irina V. Kurmaniyazov, Islam Kuzmin, Yaroslav V. Kosintsev, Pavel A. Lázničková-Galetová, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O’Drisceoil, Cóilín Orlando, Ludovic Outram, Alan Pavlova, Elena Y. Perri, Angela R. Pilot, Małgorzata Pitulko, Vladimir V. Plotnikov, Valerii V. Protopopov, Albert V. Rehazek, André Sablin, Mikhail Seguin-Orlando, Andaine Storå, Jan Verjux, Christian Zaibert, Victor F. Zazula, Grant Crombé, Philippe Hansen, Anders J. Willerslev, Eske Leonard, Jennifer A. Götherström, Anders Pinhasi, Ron Schuenemann, Verena J. Hofreiter, Michael Gilbert, M. Thomas P. Shapiro, Beth Larson, Greger Krause, Johannes Dalén, Love Skoglund, Pontus Grey wolf genomic history reveals a dual ancestry of dogs |
author_facet |
Bergström, Anders Stanton, David W. G. Taron, Ulrike H. Frantz, Laurent Sinding, Mikkel Holger S. Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophélie Girdland-Flink, Linus Fernandes, Daniel M. Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V. Ramos-Madrigal, Jazmin Feuerborn, Tatiana R. Reiter, Ella Gretzinger, Joscha Münzel, Susanne C. Swali, Pooja Conard, Nicholas J. Carøe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Hervé Brace, Selina Carden, Ruth F. Drucker, Dorothée G Fedorov, Sergey Gasparik, Mihály Germonpré, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T. Ivanova, Varvara V. Janssens, Luc Jennings, Richard P. Kasparov, Aleksei K. Kirillova, Irina V. Kurmaniyazov, Islam Kuzmin, Yaroslav V. Kosintsev, Pavel A. Lázničková-Galetová, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O’Drisceoil, Cóilín Orlando, Ludovic Outram, Alan Pavlova, Elena Y. Perri, Angela R. Pilot, Małgorzata Pitulko, Vladimir V. Plotnikov, Valerii V. Protopopov, Albert V. Rehazek, André Sablin, Mikhail Seguin-Orlando, Andaine Storå, Jan Verjux, Christian Zaibert, Victor F. Zazula, Grant Crombé, Philippe Hansen, Anders J. Willerslev, Eske Leonard, Jennifer A. Götherström, Anders Pinhasi, Ron Schuenemann, Verena J. Hofreiter, Michael Gilbert, M. Thomas P. Shapiro, Beth Larson, Greger Krause, Johannes Dalén, Love Skoglund, Pontus |
author_sort |
Bergström, Anders |
title |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_short |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_full |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_fullStr |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_full_unstemmed |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_sort |
grey wolf genomic history reveals a dual ancestry of dogs |
publishDate |
2022 |
url |
https://curis.ku.dk/portal/da/publications/grey-wolf-genomic-history-reveals-a-dual-ancestry-of-dogs(56acb259-71bf-4a15-8ca4-ec29700175a3).html https://doi.org/10.1038/s41586-022-04824-9 https://curis.ku.dk/ws/files/321964410/s41586_022_04824_9.pdf |
genre |
Canis lupus Siberia |
genre_facet |
Canis lupus Siberia |
op_source |
Bergström , A , Stanton , D W G , Taron , U H , Frantz , L , Sinding , M H S , Ersmark , E , Pfrengle , S , Cassatt-Johnstone , M , Lebrasseur , O , Girdland-Flink , L , Fernandes , D M , Ollivier , M , Speidel , L , Gopalakrishnan , S , Westbury , M V , Ramos-Madrigal , J , Feuerborn , T R , Reiter , E , Gretzinger , J , Münzel , S C , Swali , P , Conard , N J , Carøe , C , Haile , J , Linderholm , A , Androsov , S , Barnes , I , Baumann , C , Benecke , N , Bocherens , H , Brace , S , Carden , R F , Drucker , D G , Fedorov , S , Gasparik , M , Germonpré , M , Grigoriev , S , Groves , P , Hertwig , S T , Ivanova , V V , Janssens , L , Jennings , R P , Kasparov , A K , Kirillova , I V , Kurmaniyazov , I , Kuzmin , Y V , Kosintsev , P A , Lázničková-Galetová , M , Leduc , C , Nikolskiy , P , Nussbaumer , M , O’Drisceoil , C , Orlando , L , Outram , A , Pavlova , E Y , Perri , A R , Pilot , M , Pitulko , V V , Plotnikov , V V , Protopopov , A V , Rehazek , A , Sablin , M , Seguin-Orlando , A , Storå , J , Verjux , C , Zaibert , V F , Zazula , G , Crombé , P , Hansen , A J , Willerslev , E , Leonard , J A , Götherström , A , Pinhasi , R , Schuenemann , V J , Hofreiter , M , Gilbert , M T P , Shapiro , B , Larson , G , Krause , J , Dalén , L & Skoglund , P 2022 , ' Grey wolf genomic history reveals a dual ancestry of dogs ' , Nature , vol. 607 , no. 7918 , pp. 313-320 . https://doi.org/10.1038/s41586-022-04824-9 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s41586-022-04824-9 |
container_title |
Nature |
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607 |
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7918 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/56acb259-71bf-4a15-8ca4-ec29700175a3 2024-06-09T07:45:18+00:00 Grey wolf genomic history reveals a dual ancestry of dogs Bergström, Anders Stanton, David W. G. Taron, Ulrike H. Frantz, Laurent Sinding, Mikkel Holger S. Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophélie Girdland-Flink, Linus Fernandes, Daniel M. Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V. Ramos-Madrigal, Jazmin Feuerborn, Tatiana R. Reiter, Ella Gretzinger, Joscha Münzel, Susanne C. Swali, Pooja Conard, Nicholas J. Carøe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Hervé Brace, Selina Carden, Ruth F. Drucker, Dorothée G Fedorov, Sergey Gasparik, Mihály Germonpré, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T. Ivanova, Varvara V. Janssens, Luc Jennings, Richard P. Kasparov, Aleksei K. Kirillova, Irina V. Kurmaniyazov, Islam Kuzmin, Yaroslav V. Kosintsev, Pavel A. Lázničková-Galetová, Martina Leduc, Charlotte Nikolskiy, Pavel Nussbaumer, Marc O’Drisceoil, Cóilín Orlando, Ludovic Outram, Alan Pavlova, Elena Y. Perri, Angela R. Pilot, Małgorzata Pitulko, Vladimir V. Plotnikov, Valerii V. Protopopov, Albert V. Rehazek, André Sablin, Mikhail Seguin-Orlando, Andaine Storå, Jan Verjux, Christian Zaibert, Victor F. Zazula, Grant Crombé, Philippe Hansen, Anders J. Willerslev, Eske Leonard, Jennifer A. Götherström, Anders Pinhasi, Ron Schuenemann, Verena J. Hofreiter, Michael Gilbert, M. Thomas P. Shapiro, Beth Larson, Greger Krause, Johannes Dalén, Love Skoglund, Pontus 2022 application/pdf https://curis.ku.dk/portal/da/publications/grey-wolf-genomic-history-reveals-a-dual-ancestry-of-dogs(56acb259-71bf-4a15-8ca4-ec29700175a3).html https://doi.org/10.1038/s41586-022-04824-9 https://curis.ku.dk/ws/files/321964410/s41586_022_04824_9.pdf eng eng info:eu-repo/semantics/openAccess Bergström , A , Stanton , D W G , Taron , U H , Frantz , L , Sinding , M H S , Ersmark , E , Pfrengle , S , Cassatt-Johnstone , M , Lebrasseur , O , Girdland-Flink , L , Fernandes , D M , Ollivier , M , Speidel , L , Gopalakrishnan , S , Westbury , M V , Ramos-Madrigal , J , Feuerborn , T R , Reiter , E , Gretzinger , J , Münzel , S C , Swali , P , Conard , N J , Carøe , C , Haile , J , Linderholm , A , Androsov , S , Barnes , I , Baumann , C , Benecke , N , Bocherens , H , Brace , S , Carden , R F , Drucker , D G , Fedorov , S , Gasparik , M , Germonpré , M , Grigoriev , S , Groves , P , Hertwig , S T , Ivanova , V V , Janssens , L , Jennings , R P , Kasparov , A K , Kirillova , I V , Kurmaniyazov , I , Kuzmin , Y V , Kosintsev , P A , Lázničková-Galetová , M , Leduc , C , Nikolskiy , P , Nussbaumer , M , O’Drisceoil , C , Orlando , L , Outram , A , Pavlova , E Y , Perri , A R , Pilot , M , Pitulko , V V , Plotnikov , V V , Protopopov , A V , Rehazek , A , Sablin , M , Seguin-Orlando , A , Storå , J , Verjux , C , Zaibert , V F , Zazula , G , Crombé , P , Hansen , A J , Willerslev , E , Leonard , J A , Götherström , A , Pinhasi , R , Schuenemann , V J , Hofreiter , M , Gilbert , M T P , Shapiro , B , Larson , G , Krause , J , Dalén , L & Skoglund , P 2022 , ' Grey wolf genomic history reveals a dual ancestry of dogs ' , Nature , vol. 607 , no. 7918 , pp. 313-320 . https://doi.org/10.1038/s41586-022-04824-9 article 2022 ftcopenhagenunip https://doi.org/10.1038/s41586-022-04824-9 2024-05-16T11:29:26Z The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived 1–8 . Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. Article in Journal/Newspaper Canis lupus Siberia University of Copenhagen: Research Nature 607 7918 313 320 |