Dietary L-tryptophan leaves a lasting impression on the brain and the stress response
Comparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrine stress...
Published in: | British Journal of Nutrition |
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Main Authors: | , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2017
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Online Access: | https://curis.ku.dk/portal/da/publications/dietary-ltryptophan-leaves-a-lasting-impression-on-the-brain-and-the-stress-response(4cdd809d-c0ea-4d58-a42b-ea2628380120).html https://doi.org/10.1017/S0007114517001428 http://www.scopus.com/inward/record.url?scp=85020518473&partnerID=8YFLogxK http://orbit.dtu.dk/ws/files/133199371/Publishers_version.pdf |
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ftcopenhagenunip:oai:pure.atira.dk:publications/4cdd809d-c0ea-4d58-a42b-ea2628380120 2024-05-19T07:37:49+00:00 Dietary L-tryptophan leaves a lasting impression on the brain and the stress response Höglund, Erik Øverli, Øyvind Åberg Andersson, Madelene Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria Møller Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie 2017-05-28 https://curis.ku.dk/portal/da/publications/dietary-ltryptophan-leaves-a-lasting-impression-on-the-brain-and-the-stress-response(4cdd809d-c0ea-4d58-a42b-ea2628380120).html https://doi.org/10.1017/S0007114517001428 http://www.scopus.com/inward/record.url?scp=85020518473&partnerID=8YFLogxK http://orbit.dtu.dk/ws/files/133199371/Publishers_version.pdf eng eng info:eu-repo/semantics/openAccess Höglund , E , Øverli , Ø , Åberg Andersson , M , Silva , P , Laursen , D C , Moltesen , M M , Krogdahl , Å , Schjolden , J , Winberg , S , Vindas , M A , Mayer , I & Hillestad , M 2017 , ' Dietary L-tryptophan leaves a lasting impression on the brain and the stress response ' , British Journal of Nutrition , vol. 117 , no. 10 , pp. 1351-1357 . https://doi.org/10.1017/S0007114517001428 L-Tryptophan Long-term effects Monoamines article 2017 ftcopenhagenunip https://doi.org/10.1017/S0007114517001428 2024-04-25T00:45:03Z Comparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrine stress axis in all vertebrates. Still, recent fish studies suggest long-term effects of dietary Trp on stress responsiveness, which are independent of hypothalamic 5-HT. Here, we investigated if dietary Trp treatment may result in long-lasting effects on stress responsiveness, including changes in plasma cortisol levels and 5-HT neurochemistry in the telencephalon and hypothalamus of Atlantic salmon. Fish were fed diets containing one, two or three times the Trp content in normal feed for 1 week. Subsequently, fish were reintroduced to control feed and were exposed to acute crowding stress for 1 h, 8 and 21 d post Trp treatment. Generally, acute crowding resulted in lower plasma cortisol levels in fish treated with 3×Trp compared with 1×Trp- A nd 2×Trp-treated fish. The same general pattern was reflected in telencephalic 5-HTergic turnover, for which 3×Trp-treated fish showed decreased values compared with 2×Trp-treated fish. These long-term effects on post-stress plasma cortisol levels and concomitant 5-HT turnover in the telencephalon lends further support to the fact that the extrahypothalamic control of the neuroendocrine stress response is conserved within the vertebrate lineage. Moreover, they indicate that trophic/structural effects in the brain underlie the effects of dietary Trp treatment on stress reactivity. Article in Journal/Newspaper Atlantic salmon University of Copenhagen: Research British Journal of Nutrition 117 10 1351 1357 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
L-Tryptophan Long-term effects Monoamines |
spellingShingle |
L-Tryptophan Long-term effects Monoamines Höglund, Erik Øverli, Øyvind Åberg Andersson, Madelene Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria Møller Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie Dietary L-tryptophan leaves a lasting impression on the brain and the stress response |
topic_facet |
L-Tryptophan Long-term effects Monoamines |
description |
Comparative models suggest that effects of dietary tryptophan (Trp) on brain serotonin (5-hydroxytryptamine; 5-HT) neurochemistry and stress responsiveness are present throughout the vertebrate lineage. Moreover, hypothalamic 5-HT seems to play a central role in control of the neuroendocrine stress axis in all vertebrates. Still, recent fish studies suggest long-term effects of dietary Trp on stress responsiveness, which are independent of hypothalamic 5-HT. Here, we investigated if dietary Trp treatment may result in long-lasting effects on stress responsiveness, including changes in plasma cortisol levels and 5-HT neurochemistry in the telencephalon and hypothalamus of Atlantic salmon. Fish were fed diets containing one, two or three times the Trp content in normal feed for 1 week. Subsequently, fish were reintroduced to control feed and were exposed to acute crowding stress for 1 h, 8 and 21 d post Trp treatment. Generally, acute crowding resulted in lower plasma cortisol levels in fish treated with 3×Trp compared with 1×Trp- A nd 2×Trp-treated fish. The same general pattern was reflected in telencephalic 5-HTergic turnover, for which 3×Trp-treated fish showed decreased values compared with 2×Trp-treated fish. These long-term effects on post-stress plasma cortisol levels and concomitant 5-HT turnover in the telencephalon lends further support to the fact that the extrahypothalamic control of the neuroendocrine stress response is conserved within the vertebrate lineage. Moreover, they indicate that trophic/structural effects in the brain underlie the effects of dietary Trp treatment on stress reactivity. |
format |
Article in Journal/Newspaper |
author |
Höglund, Erik Øverli, Øyvind Åberg Andersson, Madelene Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria Møller Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie |
author_facet |
Höglund, Erik Øverli, Øyvind Åberg Andersson, Madelene Silva, Patricia Laursen, Danielle Caroline Moltesen, Maria Møller Krogdahl, Åshild Schjolden, Joachim Winberg, Svante Vindas, Marco A. Mayer, Ian Hillestad, Marie |
author_sort |
Höglund, Erik |
title |
Dietary L-tryptophan leaves a lasting impression on the brain and the stress response |
title_short |
Dietary L-tryptophan leaves a lasting impression on the brain and the stress response |
title_full |
Dietary L-tryptophan leaves a lasting impression on the brain and the stress response |
title_fullStr |
Dietary L-tryptophan leaves a lasting impression on the brain and the stress response |
title_full_unstemmed |
Dietary L-tryptophan leaves a lasting impression on the brain and the stress response |
title_sort |
dietary l-tryptophan leaves a lasting impression on the brain and the stress response |
publishDate |
2017 |
url |
https://curis.ku.dk/portal/da/publications/dietary-ltryptophan-leaves-a-lasting-impression-on-the-brain-and-the-stress-response(4cdd809d-c0ea-4d58-a42b-ea2628380120).html https://doi.org/10.1017/S0007114517001428 http://www.scopus.com/inward/record.url?scp=85020518473&partnerID=8YFLogxK http://orbit.dtu.dk/ws/files/133199371/Publishers_version.pdf |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Höglund , E , Øverli , Ø , Åberg Andersson , M , Silva , P , Laursen , D C , Moltesen , M M , Krogdahl , Å , Schjolden , J , Winberg , S , Vindas , M A , Mayer , I & Hillestad , M 2017 , ' Dietary L-tryptophan leaves a lasting impression on the brain and the stress response ' , British Journal of Nutrition , vol. 117 , no. 10 , pp. 1351-1357 . https://doi.org/10.1017/S0007114517001428 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1017/S0007114517001428 |
container_title |
British Journal of Nutrition |
container_volume |
117 |
container_issue |
10 |
container_start_page |
1351 |
op_container_end_page |
1357 |
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1799477196389089280 |