Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study
Udgivelsesdato: 2009-null The aim of this study was to evaluate the effect of milk supplemented with probiotic bacteria and fluoride on caries development and general health in preschool children. Children 1-5 years of age (n = 248) attending 14 day care centres with 27 units in northern Sweden ente...
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Online Access: | https://curis.ku.dk/portal/da/publications/effect-of-longterm-consumption-of-milk-supplemented-with-probiotic-lactobacilli-and-fluoride-on-dental-caries-and-general-health-in-preschool-children-a-clusterrandomized-study(43d20050-2cf5-11df-8ed1-000ea68e967b).html https://doi.org/10.1159/000235581 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/43d20050-2cf5-11df-8ed1-000ea68e967b 2024-04-28T08:32:41+00:00 Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study Stecksén-Blicks, C Sjöström, I Twetman, S 2009 https://curis.ku.dk/portal/da/publications/effect-of-longterm-consumption-of-milk-supplemented-with-probiotic-lactobacilli-and-fluoride-on-dental-caries-and-general-health-in-preschool-children-a-clusterrandomized-study(43d20050-2cf5-11df-8ed1-000ea68e967b).html https://doi.org/10.1159/000235581 eng eng info:eu-repo/semantics/restrictedAccess Stecksén-Blicks , C , Sjöström , I & Twetman , S 2009 , ' Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study ' , Caries Research , vol. 43 , no. 5 , pp. 374-81 . https://doi.org/10.1159/000235581 article 2009 ftcopenhagenunip https://doi.org/10.1159/000235581 2024-04-11T00:22:36Z Udgivelsesdato: 2009-null The aim of this study was to evaluate the effect of milk supplemented with probiotic bacteria and fluoride on caries development and general health in preschool children. Children 1-5 years of age (n = 248) attending 14 day care centres with 27 units in northern Sweden entered the study. The centres were randomly assigned to two parallel groups: children in the intervention group were served 150 ml milk supplemented with Lactobacillus rhamnosus LB21 (10(7) CFU/ml) and 2.5 mg fluoride per litre for lunch while the control group received standard milk. The double-blind intervention lasted for 21 months (weekdays) and data were collected through clinical examinations and questionnaires. The primary outcome was caries increment and secondary outcomes were measures of general health. The dropout rate was 25%. The mean baseline caries experience was 0.5 dmfs in the intervention units and 0.6 in the control units and after 21 months 0.9 and 2.2 (p < 0.05). The number of days with sick leave was similar in both groups but the children of the intervention units displayed 60% fewer days with antibiotic therapy (mean 1.9 vs. 4.7 days) and 50% less days with otitis media (0.5 vs. 1.0) (p > 0.05). In children who had participated during the whole 21-month intervention, fewer days with otitis media were reported (0.4 vs. 1.3 days, p < 0.05). No serious side effects were reported. It is concluded that daily consumption of milk containing probiotic bacteria and fluoride reduced caries in preschool children with a prevented fraction of 75%. Additional beneficial health effects were evident. Article in Journal/Newspaper Northern Sweden University of Copenhagen: Research Caries Research 43 5 374 381 |
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Open Polar |
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University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
Udgivelsesdato: 2009-null The aim of this study was to evaluate the effect of milk supplemented with probiotic bacteria and fluoride on caries development and general health in preschool children. Children 1-5 years of age (n = 248) attending 14 day care centres with 27 units in northern Sweden entered the study. The centres were randomly assigned to two parallel groups: children in the intervention group were served 150 ml milk supplemented with Lactobacillus rhamnosus LB21 (10(7) CFU/ml) and 2.5 mg fluoride per litre for lunch while the control group received standard milk. The double-blind intervention lasted for 21 months (weekdays) and data were collected through clinical examinations and questionnaires. The primary outcome was caries increment and secondary outcomes were measures of general health. The dropout rate was 25%. The mean baseline caries experience was 0.5 dmfs in the intervention units and 0.6 in the control units and after 21 months 0.9 and 2.2 (p < 0.05). The number of days with sick leave was similar in both groups but the children of the intervention units displayed 60% fewer days with antibiotic therapy (mean 1.9 vs. 4.7 days) and 50% less days with otitis media (0.5 vs. 1.0) (p > 0.05). In children who had participated during the whole 21-month intervention, fewer days with otitis media were reported (0.4 vs. 1.3 days, p < 0.05). No serious side effects were reported. It is concluded that daily consumption of milk containing probiotic bacteria and fluoride reduced caries in preschool children with a prevented fraction of 75%. Additional beneficial health effects were evident. |
format |
Article in Journal/Newspaper |
author |
Stecksén-Blicks, C Sjöström, I Twetman, S |
spellingShingle |
Stecksén-Blicks, C Sjöström, I Twetman, S Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study |
author_facet |
Stecksén-Blicks, C Sjöström, I Twetman, S |
author_sort |
Stecksén-Blicks, C |
title |
Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study |
title_short |
Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study |
title_full |
Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study |
title_fullStr |
Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study |
title_full_unstemmed |
Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study |
title_sort |
effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study |
publishDate |
2009 |
url |
https://curis.ku.dk/portal/da/publications/effect-of-longterm-consumption-of-milk-supplemented-with-probiotic-lactobacilli-and-fluoride-on-dental-caries-and-general-health-in-preschool-children-a-clusterrandomized-study(43d20050-2cf5-11df-8ed1-000ea68e967b).html https://doi.org/10.1159/000235581 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Stecksén-Blicks , C , Sjöström , I & Twetman , S 2009 , ' Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study ' , Caries Research , vol. 43 , no. 5 , pp. 374-81 . https://doi.org/10.1159/000235581 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1159/000235581 |
container_title |
Caries Research |
container_volume |
43 |
container_issue |
5 |
container_start_page |
374 |
op_container_end_page |
381 |
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