Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin
Background Atopic dermatitis (AD) endotypes differ with ethnicity. We examined the skin microbiota, cytokine and lipid profiles in Greenlandic Inuit and Danish children with AD. Methods Twenty-five Inuit children with AD and 25 Inuit control children were clinically examined and compared to previous...
Published in: | Journal of the European Academy of Dermatology and Venereology |
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Online Access: | https://curis.ku.dk/portal/da/publications/ethnic-endotypes-in-paediatric-atopic-dermatitis-depend-on-immunotype-lipid-composition-and-microbiota-of-the-skin(3f2516a2-11fa-4e1b-be42-958991fb2e10).html https://doi.org/10.1111/jdv.19565 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/3f2516a2-11fa-4e1b-be42-958991fb2e10 2024-05-19T07:41:31+00:00 Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin Andersson, A. M. Ingham, A. C. Edslev, S. M. Sølberg, J. Skov, L. Koch, A. Ghauharali-van der Vlugt, K. Stet, F. S. Brüggen, C. M. Jakasa, I. Kezic, S. Thyssen, J. P. 2024 https://curis.ku.dk/portal/da/publications/ethnic-endotypes-in-paediatric-atopic-dermatitis-depend-on-immunotype-lipid-composition-and-microbiota-of-the-skin(3f2516a2-11fa-4e1b-be42-958991fb2e10).html https://doi.org/10.1111/jdv.19565 eng eng info:eu-repo/semantics/embargoedAccess Andersson , A M , Ingham , A C , Edslev , S M , Sølberg , J , Skov , L , Koch , A , Ghauharali-van der Vlugt , K , Stet , F S , Brüggen , C M , Jakasa , I , Kezic , S & Thyssen , J P 2024 , ' Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin ' , Journal of the European Academy of Dermatology and Venereology , vol. 38 , no. 2 , pp. 365-374 . https://doi.org/10.1111/jdv.19565 article 2024 ftcopenhagenunip https://doi.org/10.1111/jdv.19565 2024-04-25T00:45:17Z Background Atopic dermatitis (AD) endotypes differ with ethnicity. We examined the skin microbiota, cytokine and lipid profiles in Greenlandic Inuit and Danish children with AD. Methods Twenty-five Inuit children with AD and 25 Inuit control children were clinically examined and compared to previously collected data from 25 Danish children with AD. Skin tape strips and skin swabs were collected from lesional and non-lesional skin. Levels of cutaneous immune biomarkers, free sphingoid bases and their (glycosyl)ceramides were analysed. Skin swabs were analysed with 16S rRNA and tuf gene for characterization of bacterial species communities. Results Bacterial β-diversity was significantly different between Inuit and Danish AD skin, in both lesional (p < 0.001) and non-lesional (p < 0.001) AD skin, and there was a higher relative abundance of Staphylococcus aureus in Danish compared to Inuit lesional (53% vs. 8%, p < 0.01) and non-lesional skin (55% vs. 5%, p < 0.001). Danish AD children had a higher α-diversity than Inuit children in non-lesional (p < 0.05) but not in lesional skin. Significantly higher levels of type 2 immunity cytokine interleukin (IL)-4 (p < 0.05) and IL-5 (p < 0.01) were identified in Inuit compared to Danish AD children. In contrast, IL-33 (p < 0.01) was higher in Danish lesional and non-lesional AD skin. Higher levels of long-chain glucosylceramide (GlcCER)[S](d26:1) were found in lesional (p < 0.001) and non-lesional (p < 0.001) Inuit skin compared with Danish AD skin. NMF levels were similar in Inuit and Danish AD skin. Conclusion Skin microbiota, cytokine and lipid composition differed significantly between Inuit and Danish children with AD and showed a stronger type 2 immune signature in Inuit children. Background: Atopic dermatitis (AD) endotypes differ with ethnicity. We examined the skin microbiota, cytokine and lipid profiles in Greenlandic Inuit and Danish children with AD. Methods: Twenty-five Inuit children with AD and 25 Inuit control children were ... Article in Journal/Newspaper greenlandic inuit University of Copenhagen: Research Journal of the European Academy of Dermatology and Venereology 38 2 365 374 |
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Open Polar |
collection |
University of Copenhagen: Research |
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ftcopenhagenunip |
language |
English |
description |
Background Atopic dermatitis (AD) endotypes differ with ethnicity. We examined the skin microbiota, cytokine and lipid profiles in Greenlandic Inuit and Danish children with AD. Methods Twenty-five Inuit children with AD and 25 Inuit control children were clinically examined and compared to previously collected data from 25 Danish children with AD. Skin tape strips and skin swabs were collected from lesional and non-lesional skin. Levels of cutaneous immune biomarkers, free sphingoid bases and their (glycosyl)ceramides were analysed. Skin swabs were analysed with 16S rRNA and tuf gene for characterization of bacterial species communities. Results Bacterial β-diversity was significantly different between Inuit and Danish AD skin, in both lesional (p < 0.001) and non-lesional (p < 0.001) AD skin, and there was a higher relative abundance of Staphylococcus aureus in Danish compared to Inuit lesional (53% vs. 8%, p < 0.01) and non-lesional skin (55% vs. 5%, p < 0.001). Danish AD children had a higher α-diversity than Inuit children in non-lesional (p < 0.05) but not in lesional skin. Significantly higher levels of type 2 immunity cytokine interleukin (IL)-4 (p < 0.05) and IL-5 (p < 0.01) were identified in Inuit compared to Danish AD children. In contrast, IL-33 (p < 0.01) was higher in Danish lesional and non-lesional AD skin. Higher levels of long-chain glucosylceramide (GlcCER)[S](d26:1) were found in lesional (p < 0.001) and non-lesional (p < 0.001) Inuit skin compared with Danish AD skin. NMF levels were similar in Inuit and Danish AD skin. Conclusion Skin microbiota, cytokine and lipid composition differed significantly between Inuit and Danish children with AD and showed a stronger type 2 immune signature in Inuit children. Background: Atopic dermatitis (AD) endotypes differ with ethnicity. We examined the skin microbiota, cytokine and lipid profiles in Greenlandic Inuit and Danish children with AD. Methods: Twenty-five Inuit children with AD and 25 Inuit control children were ... |
format |
Article in Journal/Newspaper |
author |
Andersson, A. M. Ingham, A. C. Edslev, S. M. Sølberg, J. Skov, L. Koch, A. Ghauharali-van der Vlugt, K. Stet, F. S. Brüggen, C. M. Jakasa, I. Kezic, S. Thyssen, J. P. |
spellingShingle |
Andersson, A. M. Ingham, A. C. Edslev, S. M. Sølberg, J. Skov, L. Koch, A. Ghauharali-van der Vlugt, K. Stet, F. S. Brüggen, C. M. Jakasa, I. Kezic, S. Thyssen, J. P. Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin |
author_facet |
Andersson, A. M. Ingham, A. C. Edslev, S. M. Sølberg, J. Skov, L. Koch, A. Ghauharali-van der Vlugt, K. Stet, F. S. Brüggen, C. M. Jakasa, I. Kezic, S. Thyssen, J. P. |
author_sort |
Andersson, A. M. |
title |
Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin |
title_short |
Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin |
title_full |
Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin |
title_fullStr |
Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin |
title_full_unstemmed |
Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin |
title_sort |
ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin |
publishDate |
2024 |
url |
https://curis.ku.dk/portal/da/publications/ethnic-endotypes-in-paediatric-atopic-dermatitis-depend-on-immunotype-lipid-composition-and-microbiota-of-the-skin(3f2516a2-11fa-4e1b-be42-958991fb2e10).html https://doi.org/10.1111/jdv.19565 |
genre |
greenlandic inuit |
genre_facet |
greenlandic inuit |
op_source |
Andersson , A M , Ingham , A C , Edslev , S M , Sølberg , J , Skov , L , Koch , A , Ghauharali-van der Vlugt , K , Stet , F S , Brüggen , C M , Jakasa , I , Kezic , S & Thyssen , J P 2024 , ' Ethnic endotypes in paediatric atopic dermatitis depend on immunotype, lipid composition and microbiota of the skin ' , Journal of the European Academy of Dermatology and Venereology , vol. 38 , no. 2 , pp. 365-374 . https://doi.org/10.1111/jdv.19565 |
op_rights |
info:eu-repo/semantics/embargoedAccess |
op_doi |
https://doi.org/10.1111/jdv.19565 |
container_title |
Journal of the European Academy of Dermatology and Venereology |
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38 |
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op_container_end_page |
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