Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia
In this review we trace the evolutionary connections between GnRH receptors from vertebrates and the receptors for adipokinetic hormone (AKH), AKH/corazonin-related peptide (ACP), and corazonin from arthropods. We conclude that these G protein-coupled receptors (GPCRs) are closely related and have a...
Published in: | General and Comparative Endocrinology |
---|---|
Main Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2014
|
Subjects: | |
Online Access: | https://curis.ku.dk/portal/da/publications/evolution-of-the-akhcorazoninacpgnrh-receptor-superfamily-and-their-ligands-in-the-protostomia(3b9d31c9-d2c3-4419-9c26-df72e2143932).html https://doi.org/10.1016/j.ygcen.2014.07.009 |
id |
ftcopenhagenunip:oai:pure.atira.dk:publications/3b9d31c9-d2c3-4419-9c26-df72e2143932 |
---|---|
record_format |
openpolar |
spelling |
ftcopenhagenunip:oai:pure.atira.dk:publications/3b9d31c9-d2c3-4419-9c26-df72e2143932 2024-06-09T07:45:31+00:00 Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia Hauser, Frank Grimmelikhuijzen, Cornelis 2014 https://curis.ku.dk/portal/da/publications/evolution-of-the-akhcorazoninacpgnrh-receptor-superfamily-and-their-ligands-in-the-protostomia(3b9d31c9-d2c3-4419-9c26-df72e2143932).html https://doi.org/10.1016/j.ygcen.2014.07.009 eng eng info:eu-repo/semantics/restrictedAccess Hauser , F & Grimmelikhuijzen , C 2014 , ' Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia ' , General and Comparative Endocrinology , vol. 209 , pp. 35-49 . https://doi.org/10.1016/j.ygcen.2014.07.009 article 2014 ftcopenhagenunip https://doi.org/10.1016/j.ygcen.2014.07.009 2024-05-16T11:29:15Z In this review we trace the evolutionary connections between GnRH receptors from vertebrates and the receptors for adipokinetic hormone (AKH), AKH/corazonin-related peptide (ACP), and corazonin from arthropods. We conclude that these G protein-coupled receptors (GPCRs) are closely related and have a common evolutionary origin, which dates back to the split of Proto- and Deuterostomia, about 700 million years ago. We propose that in the protostomian lineage, the ancestral GnRH-like receptor gene duplicated as did its GnRH-like ligand gene, followed by diversification, leading to (i) a corazonin receptor gene and a corazonin-like ligand gene, and (ii) an AKH receptor gene and an AKH-like ligand gene in the Mollusca and Annelida. Subsequently, the AKH receptor and ligand genes duplicated once more, yielding the situation that we know from arthropods today, where three independent hormonal systems exist, signalling with AKH, ACP, and corazonin. Our model for the evolution of GnRH signaling in the Protostomia is a striking example of receptor-ligand co-evolution. This model has been developed using several bioinformatics tools (TBLASTN searches, phylogenetic tree analyses), which also helped us to annotate six novel AKH preprohormones and their corresponding AKH sequences from the following molluscs: the sea hare Aplysia californica (AKH sequence: pQIHFSPDWGTamide), the sea slug Tritonia diomedea (pQIHFSPGWEPamide), the fresh water snail Bithynia siamensis goniomphalos (pQIHFTPGWGSamide), the owl limpet Lottia gigantea (pQIHFSPTWGSamide), the oyster Crassostrea gigas (pQVSFSTNWGSamide), and the freshwater pearl mussel Hyriopsis cumingii (pQISFSTNWGSamide). We also found AKHs in the tardigrade Hysibius dujardini (pQLSFTGWGHamide), the rotifer Brachionus calycifloros (pQLTFSSDWSGamide), and the penis worm Priapulus caudatus (pQIFFSKGWRGamide). This is the first report, showing that AKH signaling is widespread in molluscs. Article in Journal/Newspaper Crassostrea gigas Rotifer Tardigrade University of Copenhagen: Research General and Comparative Endocrinology 209 35 49 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
In this review we trace the evolutionary connections between GnRH receptors from vertebrates and the receptors for adipokinetic hormone (AKH), AKH/corazonin-related peptide (ACP), and corazonin from arthropods. We conclude that these G protein-coupled receptors (GPCRs) are closely related and have a common evolutionary origin, which dates back to the split of Proto- and Deuterostomia, about 700 million years ago. We propose that in the protostomian lineage, the ancestral GnRH-like receptor gene duplicated as did its GnRH-like ligand gene, followed by diversification, leading to (i) a corazonin receptor gene and a corazonin-like ligand gene, and (ii) an AKH receptor gene and an AKH-like ligand gene in the Mollusca and Annelida. Subsequently, the AKH receptor and ligand genes duplicated once more, yielding the situation that we know from arthropods today, where three independent hormonal systems exist, signalling with AKH, ACP, and corazonin. Our model for the evolution of GnRH signaling in the Protostomia is a striking example of receptor-ligand co-evolution. This model has been developed using several bioinformatics tools (TBLASTN searches, phylogenetic tree analyses), which also helped us to annotate six novel AKH preprohormones and their corresponding AKH sequences from the following molluscs: the sea hare Aplysia californica (AKH sequence: pQIHFSPDWGTamide), the sea slug Tritonia diomedea (pQIHFSPGWEPamide), the fresh water snail Bithynia siamensis goniomphalos (pQIHFTPGWGSamide), the owl limpet Lottia gigantea (pQIHFSPTWGSamide), the oyster Crassostrea gigas (pQVSFSTNWGSamide), and the freshwater pearl mussel Hyriopsis cumingii (pQISFSTNWGSamide). We also found AKHs in the tardigrade Hysibius dujardini (pQLSFTGWGHamide), the rotifer Brachionus calycifloros (pQLTFSSDWSGamide), and the penis worm Priapulus caudatus (pQIFFSKGWRGamide). This is the first report, showing that AKH signaling is widespread in molluscs. |
format |
Article in Journal/Newspaper |
author |
Hauser, Frank Grimmelikhuijzen, Cornelis |
spellingShingle |
Hauser, Frank Grimmelikhuijzen, Cornelis Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia |
author_facet |
Hauser, Frank Grimmelikhuijzen, Cornelis |
author_sort |
Hauser, Frank |
title |
Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia |
title_short |
Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia |
title_full |
Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia |
title_fullStr |
Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia |
title_full_unstemmed |
Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia |
title_sort |
evolution of the akh/corazonin/acp/gnrh receptor superfamily and their ligands in the protostomia |
publishDate |
2014 |
url |
https://curis.ku.dk/portal/da/publications/evolution-of-the-akhcorazoninacpgnrh-receptor-superfamily-and-their-ligands-in-the-protostomia(3b9d31c9-d2c3-4419-9c26-df72e2143932).html https://doi.org/10.1016/j.ygcen.2014.07.009 |
genre |
Crassostrea gigas Rotifer Tardigrade |
genre_facet |
Crassostrea gigas Rotifer Tardigrade |
op_source |
Hauser , F & Grimmelikhuijzen , C 2014 , ' Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia ' , General and Comparative Endocrinology , vol. 209 , pp. 35-49 . https://doi.org/10.1016/j.ygcen.2014.07.009 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.ygcen.2014.07.009 |
container_title |
General and Comparative Endocrinology |
container_volume |
209 |
container_start_page |
35 |
op_container_end_page |
49 |
_version_ |
1801374919138738176 |