Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species
The risk from POP (persistent organic pollutant) exposure and subsequent reproductive, immunotoxic and liver histopathological effects was evaluated in a classical parallel trial on Greenland sledge dogs (Canis familiaris) fed contaminated minke whale (Balaenoptera acutorostrata) blubber. First the...
Published in: | Environment International |
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Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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2016
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Online Access: | https://curis.ku.dk/portal/da/publications/risk-evaluation-of-the-arctic-environmental-pop-exposure-based-on-critical-body-residue-and-critical-daily-dose-using-captive-greenland-sledge-dogs-canis-familiaris-as-surrogate-species(3ac1e69c-9154-4d14-883e-ab78ef523959).html https://doi.org/10.1016/j.envint.2015.11.017 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/3ac1e69c-9154-4d14-883e-ab78ef523959 2024-02-11T09:59:31+01:00 Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species Sonne, Christian Gustavson, Kim Eulaers, Igor Desforges, Jean-Pierre Letcher, Robert J Rigét, Frank F Styrishave, Bjarne Dietz, Rune 2016-03 https://curis.ku.dk/portal/da/publications/risk-evaluation-of-the-arctic-environmental-pop-exposure-based-on-critical-body-residue-and-critical-daily-dose-using-captive-greenland-sledge-dogs-canis-familiaris-as-surrogate-species(3ac1e69c-9154-4d14-883e-ab78ef523959).html https://doi.org/10.1016/j.envint.2015.11.017 eng eng info:eu-repo/semantics/closedAccess Sonne , C , Gustavson , K , Eulaers , I , Desforges , J-P , Letcher , R J , Rigét , F F , Styrishave , B & Dietz , R 2016 , ' Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species ' , Environment International , vol. 88 , pp. 221-7 . https://doi.org/10.1016/j.envint.2015.11.017 Adipose Tissue Animals Arctic Regions Dogs Environmental Exposure Environmental Pollutants Female Greenland Liver Minke Whale Organic Chemicals Random Allocation Reproduction Risk Assessment Journal Article Research Support Non-U.S. Gov't article 2016 ftcopenhagenunip https://doi.org/10.1016/j.envint.2015.11.017 2024-01-18T00:01:07Z The risk from POP (persistent organic pollutant) exposure and subsequent reproductive, immunotoxic and liver histopathological effects was evaluated in a classical parallel trial on Greenland sledge dogs (Canis familiaris) fed contaminated minke whale (Balaenoptera acutorostrata) blubber. First the critical body residues (CBRs) were estimated using the physiologically-based pharmacokinetic (PBPK) model for seven POP compounds based on rat critical daily doses (CDDs). These were then compared with the actual daily oral POP doses (DD) and body residues (BR) in the sledge dogs by calculating risk quotients (RQDD: DD/CDD; RQBR: BR/CBR; ≥ 1 indicates risk). The results showed that risk quotients for reproductive, immunotoxic and liver histopathological effects were significantly lowest in the control group (p < 0.01) while risk quotients based on daily doses (RQDD) were significantly lower than RQs based on body residues (RQBR) (all p < 0.01). RQBR in the exposed group ranged from 1.0–12 for reproductive and immunotoxic effects while those for liver histopathological effects ranged from 0.7–3.0. PCBs (polychlorinated biphenyls) and chlordanes were the dominant driver behind high immune and reproductive RQs while dieldrin was the most important factor behind RQs for liver histopathology. Principal component analyses and Spearman rank correlation analyses showed that complement and cellular immune parameters were significantly negative correlated with RQBR (all p < 0.05) while logistic regression showed that RQDD had a significant effect on the number of born cups (p = 0.03). No significantly relations were found between RQs and hormone concentrations, number of gestations, antibody titres or liver histopathology. These results confirm previous studies showing that POP exposure negatively impacts steroid hormones, various immune parameters, as well as liver histopathology in sledge dogs. It is also clear that RQBR is the best reflector of health effects from POP exposure and that it is especially accurate in ... Article in Journal/Newspaper Arctic Arctic Balaenoptera acutorostrata Greenland minke whale University of Copenhagen: Research Arctic Greenland Environment International 88 221 227 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Adipose Tissue Animals Arctic Regions Dogs Environmental Exposure Environmental Pollutants Female Greenland Liver Minke Whale Organic Chemicals Random Allocation Reproduction Risk Assessment Journal Article Research Support Non-U.S. Gov't |
spellingShingle |
Adipose Tissue Animals Arctic Regions Dogs Environmental Exposure Environmental Pollutants Female Greenland Liver Minke Whale Organic Chemicals Random Allocation Reproduction Risk Assessment Journal Article Research Support Non-U.S. Gov't Sonne, Christian Gustavson, Kim Eulaers, Igor Desforges, Jean-Pierre Letcher, Robert J Rigét, Frank F Styrishave, Bjarne Dietz, Rune Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species |
topic_facet |
Adipose Tissue Animals Arctic Regions Dogs Environmental Exposure Environmental Pollutants Female Greenland Liver Minke Whale Organic Chemicals Random Allocation Reproduction Risk Assessment Journal Article Research Support Non-U.S. Gov't |
description |
The risk from POP (persistent organic pollutant) exposure and subsequent reproductive, immunotoxic and liver histopathological effects was evaluated in a classical parallel trial on Greenland sledge dogs (Canis familiaris) fed contaminated minke whale (Balaenoptera acutorostrata) blubber. First the critical body residues (CBRs) were estimated using the physiologically-based pharmacokinetic (PBPK) model for seven POP compounds based on rat critical daily doses (CDDs). These were then compared with the actual daily oral POP doses (DD) and body residues (BR) in the sledge dogs by calculating risk quotients (RQDD: DD/CDD; RQBR: BR/CBR; ≥ 1 indicates risk). The results showed that risk quotients for reproductive, immunotoxic and liver histopathological effects were significantly lowest in the control group (p < 0.01) while risk quotients based on daily doses (RQDD) were significantly lower than RQs based on body residues (RQBR) (all p < 0.01). RQBR in the exposed group ranged from 1.0–12 for reproductive and immunotoxic effects while those for liver histopathological effects ranged from 0.7–3.0. PCBs (polychlorinated biphenyls) and chlordanes were the dominant driver behind high immune and reproductive RQs while dieldrin was the most important factor behind RQs for liver histopathology. Principal component analyses and Spearman rank correlation analyses showed that complement and cellular immune parameters were significantly negative correlated with RQBR (all p < 0.05) while logistic regression showed that RQDD had a significant effect on the number of born cups (p = 0.03). No significantly relations were found between RQs and hormone concentrations, number of gestations, antibody titres or liver histopathology. These results confirm previous studies showing that POP exposure negatively impacts steroid hormones, various immune parameters, as well as liver histopathology in sledge dogs. It is also clear that RQBR is the best reflector of health effects from POP exposure and that it is especially accurate in ... |
format |
Article in Journal/Newspaper |
author |
Sonne, Christian Gustavson, Kim Eulaers, Igor Desforges, Jean-Pierre Letcher, Robert J Rigét, Frank F Styrishave, Bjarne Dietz, Rune |
author_facet |
Sonne, Christian Gustavson, Kim Eulaers, Igor Desforges, Jean-Pierre Letcher, Robert J Rigét, Frank F Styrishave, Bjarne Dietz, Rune |
author_sort |
Sonne, Christian |
title |
Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species |
title_short |
Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species |
title_full |
Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species |
title_fullStr |
Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species |
title_full_unstemmed |
Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species |
title_sort |
risk evaluation of the arctic environmental pop exposure based on critical body residue and critical daily dose using captive greenland sledge dogs (canis familiaris) as surrogate species |
publishDate |
2016 |
url |
https://curis.ku.dk/portal/da/publications/risk-evaluation-of-the-arctic-environmental-pop-exposure-based-on-critical-body-residue-and-critical-daily-dose-using-captive-greenland-sledge-dogs-canis-familiaris-as-surrogate-species(3ac1e69c-9154-4d14-883e-ab78ef523959).html https://doi.org/10.1016/j.envint.2015.11.017 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Arctic Balaenoptera acutorostrata Greenland minke whale |
genre_facet |
Arctic Arctic Balaenoptera acutorostrata Greenland minke whale |
op_source |
Sonne , C , Gustavson , K , Eulaers , I , Desforges , J-P , Letcher , R J , Rigét , F F , Styrishave , B & Dietz , R 2016 , ' Risk evaluation of the Arctic environmental POP exposure based on critical body residue and critical daily dose using captive Greenland sledge dogs (Canis familiaris) as surrogate species ' , Environment International , vol. 88 , pp. 221-7 . https://doi.org/10.1016/j.envint.2015.11.017 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.envint.2015.11.017 |
container_title |
Environment International |
container_volume |
88 |
container_start_page |
221 |
op_container_end_page |
227 |
_version_ |
1790595384445239296 |