Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?
We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs),...
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ftcopenhagenunip:oai:pure.atira.dk:publications/380b88cb-c364-4213-b5cb-ec74a355f147 2023-08-27T04:09:12+02:00 Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? Sonne, Christian Dietz, Rune Born, Erik W Riget, Frank F Kirkegaard, Maja Hyldstrup, Lars Letcher, Robert J Muir, Derek C G 2004 https://curis.ku.dk/portal/da/publications/is-bone-mineral-composition-disrupted-by-organochlorines-in-east-greenland-polar-bears-ursus-maritimus(380b88cb-c364-4213-b5cb-ec74a355f147).html eng eng info:eu-repo/semantics/restrictedAccess Sonne , C , Dietz , R , Born , E W , Riget , F F , Kirkegaard , M , Hyldstrup , L , Letcher , R J & Muir , D C G 2004 , ' Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? ' , Environmental Health Perspectives , vol. 112 , no. 17 , pp. 1711-6 . article 2004 ftcopenhagenunip 2023-08-02T23:00:23Z We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (DDT) and its metabolites, chlordanes (CHLs), dieldrin, hexacyclohexanes, hexachlorobenzene] and polybrominated diphenyl ether (PBDE) compounds. To ensure that the BMD value in skull represented the mineral status of the skeletal system in general, we compared BMD values in femur and three lumbar vertebrae with skull in a subsample. We detected highly significant correlations between BMD in skull and femur (r = 0.99; p < 0.001; n = 13) and skull and vertebrae (r = 0.97; p < 0.001; n = 8). BMD in skulls sampled in the supposed pre-organochlorine/PBDE period (1892-1932) was significantly higher than that in skulls sampled in the supposed pollution period (1966-2002) for subadult females, subadult males, and adult males (all, p < 0.05) but not adult females (p = 0.94). We found a negative correlation between organochlorines and skull BMD for the sum of PCBs (SigmaPCB; p < 0.04) and SigmaCHL (p < 0.03) in subadults and for dieldrin (p < 0.002) and SigmaDDT (p < 0.02) in adult males; indications for SigmaPBDE in subadults were also found (p = 0.06). In conclusion, the strong correlative relationships suggest that disruption of the bone mineral composition in East Greenland polar bears may have been caused by organochlorine exposure. Udgivelsesdato: 2004-Dec Article in Journal/Newspaper East Greenland Greenland Ursus maritimus University of Copenhagen: Research Greenland |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
description |
We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs), dichlorodiphenyl trichloroethane (DDT) and its metabolites, chlordanes (CHLs), dieldrin, hexacyclohexanes, hexachlorobenzene] and polybrominated diphenyl ether (PBDE) compounds. To ensure that the BMD value in skull represented the mineral status of the skeletal system in general, we compared BMD values in femur and three lumbar vertebrae with skull in a subsample. We detected highly significant correlations between BMD in skull and femur (r = 0.99; p < 0.001; n = 13) and skull and vertebrae (r = 0.97; p < 0.001; n = 8). BMD in skulls sampled in the supposed pre-organochlorine/PBDE period (1892-1932) was significantly higher than that in skulls sampled in the supposed pollution period (1966-2002) for subadult females, subadult males, and adult males (all, p < 0.05) but not adult females (p = 0.94). We found a negative correlation between organochlorines and skull BMD for the sum of PCBs (SigmaPCB; p < 0.04) and SigmaCHL (p < 0.03) in subadults and for dieldrin (p < 0.002) and SigmaDDT (p < 0.02) in adult males; indications for SigmaPBDE in subadults were also found (p = 0.06). In conclusion, the strong correlative relationships suggest that disruption of the bone mineral composition in East Greenland polar bears may have been caused by organochlorine exposure. Udgivelsesdato: 2004-Dec |
format |
Article in Journal/Newspaper |
author |
Sonne, Christian Dietz, Rune Born, Erik W Riget, Frank F Kirkegaard, Maja Hyldstrup, Lars Letcher, Robert J Muir, Derek C G |
spellingShingle |
Sonne, Christian Dietz, Rune Born, Erik W Riget, Frank F Kirkegaard, Maja Hyldstrup, Lars Letcher, Robert J Muir, Derek C G Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? |
author_facet |
Sonne, Christian Dietz, Rune Born, Erik W Riget, Frank F Kirkegaard, Maja Hyldstrup, Lars Letcher, Robert J Muir, Derek C G |
author_sort |
Sonne, Christian |
title |
Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? |
title_short |
Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? |
title_full |
Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? |
title_fullStr |
Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? |
title_full_unstemmed |
Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? |
title_sort |
is bone mineral composition disrupted by organochlorines in east greenland polar bears (ursus maritimus)? |
publishDate |
2004 |
url |
https://curis.ku.dk/portal/da/publications/is-bone-mineral-composition-disrupted-by-organochlorines-in-east-greenland-polar-bears-ursus-maritimus(380b88cb-c364-4213-b5cb-ec74a355f147).html |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
East Greenland Greenland Ursus maritimus |
genre_facet |
East Greenland Greenland Ursus maritimus |
op_source |
Sonne , C , Dietz , R , Born , E W , Riget , F F , Kirkegaard , M , Hyldstrup , L , Letcher , R J & Muir , D C G 2004 , ' Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? ' , Environmental Health Perspectives , vol. 112 , no. 17 , pp. 1711-6 . |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1775350350123892736 |