Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective da...
Published in: | International Journal of Circumpolar Health |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2017
|
Subjects: | |
Online Access: | https://curis.ku.dk/portal/da/publications/secondary-sex-ratio-in-relation-to-exposures-to-polychlorinated-biphenyls-dichlorodiphenyl-dichloroethylene-and-methylmercury(2d274916-6247-4c95-9475-b6bd83eb5d64).html https://doi.org/10.1080/22423982.2017.1406234 https://curis.ku.dk/ws/files/189104735/Secondary_sex_ratio_in_relation_to_exposures_to_polychlorinated_biphenyls_dichlorodiphenyl_dichloroethylene_and_methylmercury.pdf |
id |
ftcopenhagenunip:oai:pure.atira.dk:publications/2d274916-6247-4c95-9475-b6bd83eb5d64 |
---|---|
record_format |
openpolar |
spelling |
ftcopenhagenunip:oai:pure.atira.dk:publications/2d274916-6247-4c95-9475-b6bd83eb5d64 2023-05-15T15:55:28+02:00 Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury Timmermann, Clara Amalie Gade Choi, Anna L. Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe 2017 application/pdf https://curis.ku.dk/portal/da/publications/secondary-sex-ratio-in-relation-to-exposures-to-polychlorinated-biphenyls-dichlorodiphenyl-dichloroethylene-and-methylmercury(2d274916-6247-4c95-9475-b6bd83eb5d64).html https://doi.org/10.1080/22423982.2017.1406234 https://curis.ku.dk/ws/files/189104735/Secondary_sex_ratio_in_relation_to_exposures_to_polychlorinated_biphenyls_dichlorodiphenyl_dichloroethylene_and_methylmercury.pdf eng eng info:eu-repo/semantics/openAccess Timmermann , C A G , Choi , A L , Petersen , M S , Nielsen , F , Budtz-Jørgensen , E , Weihe , P & Grandjean , P 2017 , ' Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury ' , International Journal of Circumpolar Health , vol. 76 , no. 1 , 1406234 , pp. 1-8 . https://doi.org/10.1080/22423982.2017.1406234 Journal Article /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 /dk/atira/pure/researchoutput/pubmedpublicationtype/D052061 Research Support N.I.H. Extramural /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 Non-U.S. Gov't article 2017 ftcopenhagenunip https://doi.org/10.1080/22423982.2017.1406234 2021-09-23T18:08:11Z This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother-child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p'-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0-16%), 7% (95% CI = 0-14%) and 9% (95% CI = 2-17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention. Article in Journal/Newspaper Circumpolar Health Faroe Islands International Journal of Circumpolar Health Subarctic University of Copenhagen: Research Faroe Islands International Journal of Circumpolar Health 76 1 1406234 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Journal Article /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 /dk/atira/pure/researchoutput/pubmedpublicationtype/D052061 Research Support N.I.H. Extramural /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 Non-U.S. Gov't |
spellingShingle |
Journal Article /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 /dk/atira/pure/researchoutput/pubmedpublicationtype/D052061 Research Support N.I.H. Extramural /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 Non-U.S. Gov't Timmermann, Clara Amalie Gade Choi, Anna L. Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
topic_facet |
Journal Article /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 /dk/atira/pure/researchoutput/pubmedpublicationtype/D052061 Research Support N.I.H. Extramural /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 Non-U.S. Gov't |
description |
This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother-child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p'-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0-16%), 7% (95% CI = 0-14%) and 9% (95% CI = 2-17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention. |
format |
Article in Journal/Newspaper |
author |
Timmermann, Clara Amalie Gade Choi, Anna L. Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe |
author_facet |
Timmermann, Clara Amalie Gade Choi, Anna L. Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe |
author_sort |
Timmermann, Clara Amalie Gade |
title |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_short |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_full |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_fullStr |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_full_unstemmed |
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
title_sort |
secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury |
publishDate |
2017 |
url |
https://curis.ku.dk/portal/da/publications/secondary-sex-ratio-in-relation-to-exposures-to-polychlorinated-biphenyls-dichlorodiphenyl-dichloroethylene-and-methylmercury(2d274916-6247-4c95-9475-b6bd83eb5d64).html https://doi.org/10.1080/22423982.2017.1406234 https://curis.ku.dk/ws/files/189104735/Secondary_sex_ratio_in_relation_to_exposures_to_polychlorinated_biphenyls_dichlorodiphenyl_dichloroethylene_and_methylmercury.pdf |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Circumpolar Health Faroe Islands International Journal of Circumpolar Health Subarctic |
genre_facet |
Circumpolar Health Faroe Islands International Journal of Circumpolar Health Subarctic |
op_source |
Timmermann , C A G , Choi , A L , Petersen , M S , Nielsen , F , Budtz-Jørgensen , E , Weihe , P & Grandjean , P 2017 , ' Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury ' , International Journal of Circumpolar Health , vol. 76 , no. 1 , 1406234 , pp. 1-8 . https://doi.org/10.1080/22423982.2017.1406234 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2017.1406234 |
container_title |
International Journal of Circumpolar Health |
container_volume |
76 |
container_issue |
1 |
container_start_page |
1406234 |
_version_ |
1766390964397539328 |