Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12

X-chromosome markers have become a useful set of markers of choice when certain complex kinship cases need to be unravelled. The Argus X-12 kit allows the co-amplification in a single PCR reaction of 12 X-chromosome short tandem repeats located in four linkage groups. A number of 507 unrelated indiv...

Full description

Bibliographic Details
Published in:International Journal of Legal Medicine
Main Authors: Tomas Mas, Carmen, Pereira, Vania, Morling, Niels
Format: Article in Journal/Newspaper
Language:English
Published: 2012
Subjects:
Online Access:https://curis.ku.dk/portal/da/publications/analysis-of-12-xstrs-in-greenlanders-danes-and-somalis-using-argus-x12(27f6a5de-e764-4860-916d-9401bd6636d1).html
https://doi.org/10.1007/s00414-011-0609-y
id ftcopenhagenunip:oai:pure.atira.dk:publications/27f6a5de-e764-4860-916d-9401bd6636d1
record_format openpolar
spelling ftcopenhagenunip:oai:pure.atira.dk:publications/27f6a5de-e764-4860-916d-9401bd6636d1 2024-05-19T07:41:10+00:00 Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12 Tomas Mas, Carmen Pereira, Vania Morling, Niels 2012-01 https://curis.ku.dk/portal/da/publications/analysis-of-12-xstrs-in-greenlanders-danes-and-somalis-using-argus-x12(27f6a5de-e764-4860-916d-9401bd6636d1).html https://doi.org/10.1007/s00414-011-0609-y eng eng info:eu-repo/semantics/restrictedAccess Tomas Mas , C , Pereira , V & Morling , N 2012 , ' Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12 ' , International Journal of Legal Medicine (Print) , vol. 126 , no. 1 , pp. 121-128 . https://doi.org/10.1007/s00414-011-0609-y article 2012 ftcopenhagenunip https://doi.org/10.1007/s00414-011-0609-y 2024-05-02T00:33:07Z X-chromosome markers have become a useful set of markers of choice when certain complex kinship cases need to be unravelled. The Argus X-12 kit allows the co-amplification in a single PCR reaction of 12 X-chromosome short tandem repeats located in four linkage groups. A number of 507 unrelated individuals from Greenland, Denmark and Somalia together with two generation families were typed using the Argus X-12 kit. Silent alleles for the DXS10148 and DXS10146 systems were observed in males, mostly from Somalia. High levels of intrapopulation variability and therefore high forensic parameter values were calculated for the three studied populations. The population in Greenland showed a significantly lower intrapopulation variability and a high genetic differentiation compared with 13 other populations. Significant levels of linkage disequilibrium were observed between markers belonging to the same linkage group, mainly in the populations in Greenland and Somalia. Family studies allowed the calculation of mutation and recombination frequencies. A higher male versus female mutation rate was obtained, with an average value of 3.3¿×¿10(-3). Recombination fraction calculations performed on two generation families showed, as previously described, a not complete independence between X-chromosome linkage groups 3 and 4. Article in Journal/Newspaper Greenland greenlander* University of Copenhagen: Research International Journal of Legal Medicine 126 1 121 128
institution Open Polar
collection University of Copenhagen: Research
op_collection_id ftcopenhagenunip
language English
description X-chromosome markers have become a useful set of markers of choice when certain complex kinship cases need to be unravelled. The Argus X-12 kit allows the co-amplification in a single PCR reaction of 12 X-chromosome short tandem repeats located in four linkage groups. A number of 507 unrelated individuals from Greenland, Denmark and Somalia together with two generation families were typed using the Argus X-12 kit. Silent alleles for the DXS10148 and DXS10146 systems were observed in males, mostly from Somalia. High levels of intrapopulation variability and therefore high forensic parameter values were calculated for the three studied populations. The population in Greenland showed a significantly lower intrapopulation variability and a high genetic differentiation compared with 13 other populations. Significant levels of linkage disequilibrium were observed between markers belonging to the same linkage group, mainly in the populations in Greenland and Somalia. Family studies allowed the calculation of mutation and recombination frequencies. A higher male versus female mutation rate was obtained, with an average value of 3.3¿×¿10(-3). Recombination fraction calculations performed on two generation families showed, as previously described, a not complete independence between X-chromosome linkage groups 3 and 4.
format Article in Journal/Newspaper
author Tomas Mas, Carmen
Pereira, Vania
Morling, Niels
spellingShingle Tomas Mas, Carmen
Pereira, Vania
Morling, Niels
Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12
author_facet Tomas Mas, Carmen
Pereira, Vania
Morling, Niels
author_sort Tomas Mas, Carmen
title Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12
title_short Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12
title_full Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12
title_fullStr Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12
title_full_unstemmed Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12
title_sort analysis of 12 x-strs in greenlanders, danes and somalis using argus x-12
publishDate 2012
url https://curis.ku.dk/portal/da/publications/analysis-of-12-xstrs-in-greenlanders-danes-and-somalis-using-argus-x12(27f6a5de-e764-4860-916d-9401bd6636d1).html
https://doi.org/10.1007/s00414-011-0609-y
genre Greenland
greenlander*
genre_facet Greenland
greenlander*
op_source Tomas Mas , C , Pereira , V & Morling , N 2012 , ' Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12 ' , International Journal of Legal Medicine (Print) , vol. 126 , no. 1 , pp. 121-128 . https://doi.org/10.1007/s00414-011-0609-y
op_rights info:eu-repo/semantics/restrictedAccess
op_doi https://doi.org/10.1007/s00414-011-0609-y
container_title International Journal of Legal Medicine
container_volume 126
container_issue 1
container_start_page 121
op_container_end_page 128
_version_ 1799480753667440640