A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene
Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors....
Published in: | European Journal of Human Genetics |
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Online Access: | https://curis.ku.dk/portal/da/publications/a-genomewide-study-of-panic-disorder-suggests-the-amiloridesensitive-cation-channel-1-as-a-candidate-gene(1fbb8114-1c68-4fd4-8913-ea1278c898e6).html https://doi.org/10.1038/ejhg.2011.148 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/1fbb8114-1c68-4fd4-8913-ea1278c898e6 2023-05-15T16:10:53+02:00 A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette Nørmølle Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G Joensen, Sofus Woldbye, David Pd Koefoed, Pernille Kristensen, Ann Suhl Kruse, Torben A Børglum, Anders Mors, Ole 2012 https://curis.ku.dk/portal/da/publications/a-genomewide-study-of-panic-disorder-suggests-the-amiloridesensitive-cation-channel-1-as-a-candidate-gene(1fbb8114-1c68-4fd4-8913-ea1278c898e6).html https://doi.org/10.1038/ejhg.2011.148 eng eng info:eu-repo/semantics/restrictedAccess Gregersen , N , Dahl , H A , Buttenschøn , H N , Nyegaard , M , Hedemand , A , Als , T D , Wang , A G , Joensen , S , Woldbye , D P , Koefoed , P , Kristensen , A S , Kruse , T A , Børglum , A & Mors , O 2012 , ' A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene ' , European Journal of Human Genetics , vol. 20 , pp. 84-90 . https://doi.org/10.1038/ejhg.2011.148 article 2012 ftcopenhagenunip https://doi.org/10.1038/ejhg.2011.148 2022-02-24T00:07:16Z Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.European Journal of Human Genetics advance online publication, 3 August 2011; doi:10.1038/ejhg.2011.148. Article in Journal/Newspaper Faroe Islands University of Copenhagen: Research Faroe Islands European Journal of Human Genetics 20 1 84 90 |
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Open Polar |
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University of Copenhagen: Research |
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ftcopenhagenunip |
language |
English |
description |
Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.European Journal of Human Genetics advance online publication, 3 August 2011; doi:10.1038/ejhg.2011.148. |
format |
Article in Journal/Newspaper |
author |
Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette Nørmølle Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G Joensen, Sofus Woldbye, David Pd Koefoed, Pernille Kristensen, Ann Suhl Kruse, Torben A Børglum, Anders Mors, Ole |
spellingShingle |
Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette Nørmølle Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G Joensen, Sofus Woldbye, David Pd Koefoed, Pernille Kristensen, Ann Suhl Kruse, Torben A Børglum, Anders Mors, Ole A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
author_facet |
Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette Nørmølle Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G Joensen, Sofus Woldbye, David Pd Koefoed, Pernille Kristensen, Ann Suhl Kruse, Torben A Børglum, Anders Mors, Ole |
author_sort |
Gregersen, Noomi |
title |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_short |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_full |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_fullStr |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_full_unstemmed |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_sort |
genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
publishDate |
2012 |
url |
https://curis.ku.dk/portal/da/publications/a-genomewide-study-of-panic-disorder-suggests-the-amiloridesensitive-cation-channel-1-as-a-candidate-gene(1fbb8114-1c68-4fd4-8913-ea1278c898e6).html https://doi.org/10.1038/ejhg.2011.148 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Gregersen , N , Dahl , H A , Buttenschøn , H N , Nyegaard , M , Hedemand , A , Als , T D , Wang , A G , Joensen , S , Woldbye , D P , Koefoed , P , Kristensen , A S , Kruse , T A , Børglum , A & Mors , O 2012 , ' A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene ' , European Journal of Human Genetics , vol. 20 , pp. 84-90 . https://doi.org/10.1038/ejhg.2011.148 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1038/ejhg.2011.148 |
container_title |
European Journal of Human Genetics |
container_volume |
20 |
container_issue |
1 |
container_start_page |
84 |
op_container_end_page |
90 |
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1765996013537984512 |