Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study
BACKGROUND: Atopic dermatitis (AD) appears to be more common in regions with hard domestic water and in children with a fall/winter birth. However, it is unknown whether a synergistic effect exists. OBJECTIVE: We sought to evaluate the association between domestic water hardness and season of birth,...
Published in: | Journal of Allergy and Clinical Immunology |
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Online Access: | https://curis.ku.dk/portal/da/publications/prevalence-of-atopic-dermatitis-in-infants-by-domestic-water-hardness-and-season-of-birth(1a7a8f9f-1acf-4e06-84c9-6edaf1a05fe7).html https://doi.org/10.1016/j.jaci.2016.11.021 |
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ftcopenhagenunip:oai:pure.atira.dk:publications/1a7a8f9f-1acf-4e06-84c9-6edaf1a05fe7 2024-05-12T08:04:41+00:00 Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study Engebretsen, Kristiane A Bager, Peter Wohlfahrt, Jan Skov, Lone Zachariae, Claus Nybo Andersen, Anne-Marie Melbye, Mads Thyssen, Jacob P 2017-05 https://curis.ku.dk/portal/da/publications/prevalence-of-atopic-dermatitis-in-infants-by-domestic-water-hardness-and-season-of-birth(1a7a8f9f-1acf-4e06-84c9-6edaf1a05fe7).html https://doi.org/10.1016/j.jaci.2016.11.021 eng eng info:eu-repo/semantics/closedAccess Engebretsen , K A , Bager , P , Wohlfahrt , J , Skov , L , Zachariae , C , Nybo Andersen , A-M , Melbye , M & Thyssen , J P 2017 , ' Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth : Cohort study ' , The Journal of allergy and clinical immunology , vol. 139 , no. 5 , pp. 1568-1574.e1 . https://doi.org/10.1016/j.jaci.2016.11.021 Journal Article article 2017 ftcopenhagenunip https://doi.org/10.1016/j.jaci.2016.11.021 2024-04-18T00:28:13Z BACKGROUND: Atopic dermatitis (AD) appears to be more common in regions with hard domestic water and in children with a fall/winter birth. However, it is unknown whether a synergistic effect exists. OBJECTIVE: We sought to evaluate the association between domestic water hardness and season of birth, respectively, with onset of AD within the first 18 months of life in a large Danish birth cohort. METHODS: Of children from the Danish National Birth Cohort, 52,950 were included. History of physician-diagnosed AD and population characteristics were obtained from interviews. Birth data were obtained from the Civil Registration System, and domestic water hardness data were obtained from the Geological Survey of Denmark and Greenland. The relative prevalence (RP) of AD was calculated by using log-linear binomial regression. RESULTS: The prevalence of AD was 15.0% (7,942/52,950). The RP of AD was 5% (RPtrend, 1.05; 95% CI, 1.03-1.07) higher for each 5° increase in domestic water hardness (range, 6.60-35.90 German degrees of hardness [118-641 mg/L]). Although the RP of AD was higher in children with a fall (RP, 1.24; 95% CI, 1.17-1.31) or winter (RP, 1.18; 95% CI, 1.11-1.25) birth, no significant interaction was observed with domestic water hardness. The population attributable risk of hard domestic water on AD was 2%. CONCLUSION: We observed that early exposure to hard domestic water and a fall/winter birth was associated with an increase in the relative prevalence of AD within the first 18 months of life. Although the 2 exposures did not interact synergistically, a dose-response relationship was observed between domestic water hardness and AD. Article in Journal/Newspaper Greenland University of Copenhagen: Research Greenland Journal of Allergy and Clinical Immunology 139 5 1568 1574.e1 |
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Journal Article Engebretsen, Kristiane A Bager, Peter Wohlfahrt, Jan Skov, Lone Zachariae, Claus Nybo Andersen, Anne-Marie Melbye, Mads Thyssen, Jacob P Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study |
topic_facet |
Journal Article |
description |
BACKGROUND: Atopic dermatitis (AD) appears to be more common in regions with hard domestic water and in children with a fall/winter birth. However, it is unknown whether a synergistic effect exists. OBJECTIVE: We sought to evaluate the association between domestic water hardness and season of birth, respectively, with onset of AD within the first 18 months of life in a large Danish birth cohort. METHODS: Of children from the Danish National Birth Cohort, 52,950 were included. History of physician-diagnosed AD and population characteristics were obtained from interviews. Birth data were obtained from the Civil Registration System, and domestic water hardness data were obtained from the Geological Survey of Denmark and Greenland. The relative prevalence (RP) of AD was calculated by using log-linear binomial regression. RESULTS: The prevalence of AD was 15.0% (7,942/52,950). The RP of AD was 5% (RPtrend, 1.05; 95% CI, 1.03-1.07) higher for each 5° increase in domestic water hardness (range, 6.60-35.90 German degrees of hardness [118-641 mg/L]). Although the RP of AD was higher in children with a fall (RP, 1.24; 95% CI, 1.17-1.31) or winter (RP, 1.18; 95% CI, 1.11-1.25) birth, no significant interaction was observed with domestic water hardness. The population attributable risk of hard domestic water on AD was 2%. CONCLUSION: We observed that early exposure to hard domestic water and a fall/winter birth was associated with an increase in the relative prevalence of AD within the first 18 months of life. Although the 2 exposures did not interact synergistically, a dose-response relationship was observed between domestic water hardness and AD. |
format |
Article in Journal/Newspaper |
author |
Engebretsen, Kristiane A Bager, Peter Wohlfahrt, Jan Skov, Lone Zachariae, Claus Nybo Andersen, Anne-Marie Melbye, Mads Thyssen, Jacob P |
author_facet |
Engebretsen, Kristiane A Bager, Peter Wohlfahrt, Jan Skov, Lone Zachariae, Claus Nybo Andersen, Anne-Marie Melbye, Mads Thyssen, Jacob P |
author_sort |
Engebretsen, Kristiane A |
title |
Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study |
title_short |
Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study |
title_full |
Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study |
title_fullStr |
Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study |
title_full_unstemmed |
Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:Cohort study |
title_sort |
prevalence of atopic dermatitis in infants by domestic water hardness and season of birth:cohort study |
publishDate |
2017 |
url |
https://curis.ku.dk/portal/da/publications/prevalence-of-atopic-dermatitis-in-infants-by-domestic-water-hardness-and-season-of-birth(1a7a8f9f-1acf-4e06-84c9-6edaf1a05fe7).html https://doi.org/10.1016/j.jaci.2016.11.021 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Engebretsen , K A , Bager , P , Wohlfahrt , J , Skov , L , Zachariae , C , Nybo Andersen , A-M , Melbye , M & Thyssen , J P 2017 , ' Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth : Cohort study ' , The Journal of allergy and clinical immunology , vol. 139 , no. 5 , pp. 1568-1574.e1 . https://doi.org/10.1016/j.jaci.2016.11.021 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.jaci.2016.11.021 |
container_title |
Journal of Allergy and Clinical Immunology |
container_volume |
139 |
container_issue |
5 |
container_start_page |
1568 |
op_container_end_page |
1574.e1 |
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1798846925504512000 |