Temporal dynamics of woolly mammoth genome erosion prior to extinction
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a fe...
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2024
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ftcopenhagenunip:oai:pure.atira.dk:publications/177486e9-fdcc-4831-ad53-6e64328ee411 2024-09-15T18:40:47+00:00 Temporal dynamics of woolly mammoth genome erosion prior to extinction Dehasque, Marianne Morales, Hernán E. Díez-del-Molino, David Pečnerová, Patrícia Chacón-Duque, J. Camilo Kanellidou, Foteini Muller, Héloïse Plotnikov, Valerii Protopopov, Albert Tikhonov, Alexei Nikolskiy, Pavel Danilov, Gleb K. Giannì, Maddalena van der Sluis, Laura Higham, Tom Heintzman, Peter D. Oskolkov, Nikolay Gilbert, M. Thomas P. Götherström, Anders van der Valk, Tom Vartanyan, Sergey Dalén, Love 2024 application/pdf https://curis.ku.dk/portal/da/publications/temporal-dynamics-of-woolly-mammoth-genome-erosion-prior-to-extinction(177486e9-fdcc-4831-ad53-6e64328ee411).html https://doi.org/10.1016/j.cell.2024.05.033 https://curis.ku.dk/ws/files/401202016/1_s2.0_S0092867424005774_main.pdf eng eng info:eu-repo/semantics/openAccess Dehasque , M , Morales , H E , Díez-del-Molino , D , Pečnerová , P , Chacón-Duque , J C , Kanellidou , F , Muller , H , Plotnikov , V , Protopopov , A , Tikhonov , A , Nikolskiy , P , Danilov , G K , Giannì , M , van der Sluis , L , Higham , T , Heintzman , P D , Oskolkov , N , Gilbert , M T P , Götherström , A , van der Valk , T , Vartanyan , S & Dalén , L 2024 , ' Temporal dynamics of woolly mammoth genome erosion prior to extinction ' , Cell , vol. 187 , no. 14 , pp. 3531-3540.e13 . https://doi.org/10.1016/j.cell.2024.05.033 ancient DNA bottleneck climate extinction inbreeding Mammuthus primigenius mutation load paleogenomics woolly mammoth Wrangel Island article 2024 ftcopenhagenunip https://doi.org/10.1016/j.cell.2024.05.033 2024-09-02T14:28:57Z A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations. A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding ... Article in Journal/Newspaper Wrangel Island University of Copenhagen: Research Cell 187 14 3531 3540.e13 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
ancient DNA bottleneck climate extinction inbreeding Mammuthus primigenius mutation load paleogenomics woolly mammoth Wrangel Island |
spellingShingle |
ancient DNA bottleneck climate extinction inbreeding Mammuthus primigenius mutation load paleogenomics woolly mammoth Wrangel Island Dehasque, Marianne Morales, Hernán E. Díez-del-Molino, David Pečnerová, Patrícia Chacón-Duque, J. Camilo Kanellidou, Foteini Muller, Héloïse Plotnikov, Valerii Protopopov, Albert Tikhonov, Alexei Nikolskiy, Pavel Danilov, Gleb K. Giannì, Maddalena van der Sluis, Laura Higham, Tom Heintzman, Peter D. Oskolkov, Nikolay Gilbert, M. Thomas P. Götherström, Anders van der Valk, Tom Vartanyan, Sergey Dalén, Love Temporal dynamics of woolly mammoth genome erosion prior to extinction |
topic_facet |
ancient DNA bottleneck climate extinction inbreeding Mammuthus primigenius mutation load paleogenomics woolly mammoth Wrangel Island |
description |
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations. A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding ... |
format |
Article in Journal/Newspaper |
author |
Dehasque, Marianne Morales, Hernán E. Díez-del-Molino, David Pečnerová, Patrícia Chacón-Duque, J. Camilo Kanellidou, Foteini Muller, Héloïse Plotnikov, Valerii Protopopov, Albert Tikhonov, Alexei Nikolskiy, Pavel Danilov, Gleb K. Giannì, Maddalena van der Sluis, Laura Higham, Tom Heintzman, Peter D. Oskolkov, Nikolay Gilbert, M. Thomas P. Götherström, Anders van der Valk, Tom Vartanyan, Sergey Dalén, Love |
author_facet |
Dehasque, Marianne Morales, Hernán E. Díez-del-Molino, David Pečnerová, Patrícia Chacón-Duque, J. Camilo Kanellidou, Foteini Muller, Héloïse Plotnikov, Valerii Protopopov, Albert Tikhonov, Alexei Nikolskiy, Pavel Danilov, Gleb K. Giannì, Maddalena van der Sluis, Laura Higham, Tom Heintzman, Peter D. Oskolkov, Nikolay Gilbert, M. Thomas P. Götherström, Anders van der Valk, Tom Vartanyan, Sergey Dalén, Love |
author_sort |
Dehasque, Marianne |
title |
Temporal dynamics of woolly mammoth genome erosion prior to extinction |
title_short |
Temporal dynamics of woolly mammoth genome erosion prior to extinction |
title_full |
Temporal dynamics of woolly mammoth genome erosion prior to extinction |
title_fullStr |
Temporal dynamics of woolly mammoth genome erosion prior to extinction |
title_full_unstemmed |
Temporal dynamics of woolly mammoth genome erosion prior to extinction |
title_sort |
temporal dynamics of woolly mammoth genome erosion prior to extinction |
publishDate |
2024 |
url |
https://curis.ku.dk/portal/da/publications/temporal-dynamics-of-woolly-mammoth-genome-erosion-prior-to-extinction(177486e9-fdcc-4831-ad53-6e64328ee411).html https://doi.org/10.1016/j.cell.2024.05.033 https://curis.ku.dk/ws/files/401202016/1_s2.0_S0092867424005774_main.pdf |
genre |
Wrangel Island |
genre_facet |
Wrangel Island |
op_source |
Dehasque , M , Morales , H E , Díez-del-Molino , D , Pečnerová , P , Chacón-Duque , J C , Kanellidou , F , Muller , H , Plotnikov , V , Protopopov , A , Tikhonov , A , Nikolskiy , P , Danilov , G K , Giannì , M , van der Sluis , L , Higham , T , Heintzman , P D , Oskolkov , N , Gilbert , M T P , Götherström , A , van der Valk , T , Vartanyan , S & Dalén , L 2024 , ' Temporal dynamics of woolly mammoth genome erosion prior to extinction ' , Cell , vol. 187 , no. 14 , pp. 3531-3540.e13 . https://doi.org/10.1016/j.cell.2024.05.033 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.cell.2024.05.033 |
container_title |
Cell |
container_volume |
187 |
container_issue |
14 |
container_start_page |
3531 |
op_container_end_page |
3540.e13 |
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1810485179237531648 |