A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds
Polycyclic aromatic compounds (PACs) possess toxicity towards humans, and their presence in the environment is unwanted. Polar transformation products (TPs) are more mobile, and can be considered emerging contaminants, as they represent a more bioavailable carrier of the same toxic properties. Acidi...
Published in: | Chemosphere |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2019
|
Subjects: | |
Online Access: | https://curis.ku.dk/portal/da/publications/a-tiered-analytical-approach-for-target-nontarget-and-suspect-screening-analysis-of-polar-transformation-products-of-polycyclic-aromatic-compounds(16e01769-09f6-4f8d-932c-d3c4e1606c8f).html https://doi.org/10.1016/j.chemosphere.2019.06.149 http://www.scopus.com/inward/record.url?scp=85067834575&partnerID=8YFLogxK |
id |
ftcopenhagenunip:oai:pure.atira.dk:publications/16e01769-09f6-4f8d-932c-d3c4e1606c8f |
---|---|
record_format |
openpolar |
spelling |
ftcopenhagenunip:oai:pure.atira.dk:publications/16e01769-09f6-4f8d-932c-d3c4e1606c8f 2024-05-12T07:59:49+00:00 A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds Schemeth, Dieter Nielsen, Nikoline J. Andersson, Jan T. Christensen, Jan H. 2019-11-01 https://curis.ku.dk/portal/da/publications/a-tiered-analytical-approach-for-target-nontarget-and-suspect-screening-analysis-of-polar-transformation-products-of-polycyclic-aromatic-compounds(16e01769-09f6-4f8d-932c-d3c4e1606c8f).html https://doi.org/10.1016/j.chemosphere.2019.06.149 http://www.scopus.com/inward/record.url?scp=85067834575&partnerID=8YFLogxK eng eng info:eu-repo/semantics/closedAccess Schemeth , D , Nielsen , N J , Andersson , J T & Christensen , J H 2019 , ' A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds ' , Chemosphere , vol. 235 , pp. 175-184 . https://doi.org/10.1016/j.chemosphere.2019.06.149 Environmental arctic pollution GC-MS Group-type fractionation LC-MS Non-target analysis PAC transformation Suspect screening article 2019 ftcopenhagenunip https://doi.org/10.1016/j.chemosphere.2019.06.149 2024-04-18T00:28:15Z Polycyclic aromatic compounds (PACs) possess toxicity towards humans, and their presence in the environment is unwanted. Polar transformation products (TPs) are more mobile, and can be considered emerging contaminants, as they represent a more bioavailable carrier of the same toxic properties. Acidic TPs has been proposed as an important class of polar TPs. This study presents a tiered analytical approach to investigate acidic and polar PAC TPs in environmental conditions. The tiered approach exploits target analysis for quantification of acids; suspect screening for tentative identification based on retention time and spectral matching using databases; and finally non-target analysis based on chromatography and data independent broadband MS to highlight potentially unknown analyte peaks. The approach includes a mixed-mode anion exchange solid phase extraction (MAX-SPE) to fractionate neutral and acidic compounds, and is applied to three cases: I) Photo-oxidation of six PACs generated suspected hydroxylated-, carbonylated- and carboxylated PACs but also proposed the presence of mono- and dicarboxylic acids, which have not been reported elsewhere. For a subset of four acids, conversion rates were determined. II) Recovery of spiked acids from diesel spilled harbor water was 80% by LC-MS, and diesel spill weathering was evaluated from the neutral fraction by GC-MS. III) By non-target analysis sulfonated PACs, presumable derived from photo-oxidation, were detected in run-off basins of an arctic landfarm, alongside hypothesized naturally occuring fatty acids. The tiered approach is a sensitive and versatile tool to extract information on PACs and their polar TPs from polluted environmental sites. Article in Journal/Newspaper Arctic Arctic pollution University of Copenhagen: Research Arctic Chemosphere 235 175 184 |
institution |
Open Polar |
collection |
University of Copenhagen: Research |
op_collection_id |
ftcopenhagenunip |
language |
English |
topic |
Environmental arctic pollution GC-MS Group-type fractionation LC-MS Non-target analysis PAC transformation Suspect screening |
spellingShingle |
Environmental arctic pollution GC-MS Group-type fractionation LC-MS Non-target analysis PAC transformation Suspect screening Schemeth, Dieter Nielsen, Nikoline J. Andersson, Jan T. Christensen, Jan H. A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds |
topic_facet |
Environmental arctic pollution GC-MS Group-type fractionation LC-MS Non-target analysis PAC transformation Suspect screening |
description |
Polycyclic aromatic compounds (PACs) possess toxicity towards humans, and their presence in the environment is unwanted. Polar transformation products (TPs) are more mobile, and can be considered emerging contaminants, as they represent a more bioavailable carrier of the same toxic properties. Acidic TPs has been proposed as an important class of polar TPs. This study presents a tiered analytical approach to investigate acidic and polar PAC TPs in environmental conditions. The tiered approach exploits target analysis for quantification of acids; suspect screening for tentative identification based on retention time and spectral matching using databases; and finally non-target analysis based on chromatography and data independent broadband MS to highlight potentially unknown analyte peaks. The approach includes a mixed-mode anion exchange solid phase extraction (MAX-SPE) to fractionate neutral and acidic compounds, and is applied to three cases: I) Photo-oxidation of six PACs generated suspected hydroxylated-, carbonylated- and carboxylated PACs but also proposed the presence of mono- and dicarboxylic acids, which have not been reported elsewhere. For a subset of four acids, conversion rates were determined. II) Recovery of spiked acids from diesel spilled harbor water was 80% by LC-MS, and diesel spill weathering was evaluated from the neutral fraction by GC-MS. III) By non-target analysis sulfonated PACs, presumable derived from photo-oxidation, were detected in run-off basins of an arctic landfarm, alongside hypothesized naturally occuring fatty acids. The tiered approach is a sensitive and versatile tool to extract information on PACs and their polar TPs from polluted environmental sites. |
format |
Article in Journal/Newspaper |
author |
Schemeth, Dieter Nielsen, Nikoline J. Andersson, Jan T. Christensen, Jan H. |
author_facet |
Schemeth, Dieter Nielsen, Nikoline J. Andersson, Jan T. Christensen, Jan H. |
author_sort |
Schemeth, Dieter |
title |
A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds |
title_short |
A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds |
title_full |
A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds |
title_fullStr |
A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds |
title_full_unstemmed |
A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds |
title_sort |
tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds |
publishDate |
2019 |
url |
https://curis.ku.dk/portal/da/publications/a-tiered-analytical-approach-for-target-nontarget-and-suspect-screening-analysis-of-polar-transformation-products-of-polycyclic-aromatic-compounds(16e01769-09f6-4f8d-932c-d3c4e1606c8f).html https://doi.org/10.1016/j.chemosphere.2019.06.149 http://www.scopus.com/inward/record.url?scp=85067834575&partnerID=8YFLogxK |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Arctic pollution |
genre_facet |
Arctic Arctic pollution |
op_source |
Schemeth , D , Nielsen , N J , Andersson , J T & Christensen , J H 2019 , ' A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds ' , Chemosphere , vol. 235 , pp. 175-184 . https://doi.org/10.1016/j.chemosphere.2019.06.149 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.chemosphere.2019.06.149 |
container_title |
Chemosphere |
container_volume |
235 |
container_start_page |
175 |
op_container_end_page |
184 |
_version_ |
1798841437040672768 |